ENSG00000115756

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307845 ENSG00000115756 HEK293_OSMI2_6hA HEK293_TMG_6hB HPCAL1 protein_coding protein_coding 22.58443 35.13411 12.41645 6.476559 0.7824615 -1.499869 8.3038226 13.287712 2.605878 2.4582298 0.21535593 -2.34581078 0.38093750 0.3780667 0.21060000 -0.167466667 0.0004561048 0.0004561048 FALSE TRUE
ENST00000419810 ENSG00000115756 HEK293_OSMI2_6hA HEK293_TMG_6hB HPCAL1 protein_coding nonsense_mediated_decay 22.58443 35.13411 12.41645 6.476559 0.7824615 -1.499869 0.9105456 1.169403 1.155586 0.1852423 0.07475055 -0.01700226 0.05026250 0.0379000 0.09446667 0.056566667 0.2026635086 0.0004561048 TRUE TRUE
ENST00000622018 ENSG00000115756 HEK293_OSMI2_6hA HEK293_TMG_6hB HPCAL1 protein_coding protein_coding 22.58443 35.13411 12.41645 6.476559 0.7824615 -1.499869 10.8712619 16.882434 7.800527 4.1018339 0.88473637 -1.11288549 0.43974583 0.4667000 0.62443333 0.157733333 0.2187979832 0.0004561048 FALSE TRUE
MSTRG.17946.2 ENSG00000115756 HEK293_OSMI2_6hA HEK293_TMG_6hB HPCAL1 protein_coding   22.58443 35.13411 12.41645 6.476559 0.7824615 -1.499869 1.2793608 1.798791 0.439360 0.8997311 0.31881441 -2.00908214 0.05970833 0.0433000 0.03596667 -0.007333333 0.9746253494 0.0004561048 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115756 E001 2.1538180 0.0102861921 8.507579e-02 0.2547578300 2 10302889 10302893 5 + 0.658 0.349 -1.527
ENSG00000115756 E002 2.8321691 0.0085156777 3.006708e-01 0.5411415141 2 10302894 10302896 3 + 0.658 0.468 -0.874
ENSG00000115756 E003 5.7962313 0.0548817431 8.305254e-01 0.9140828446 2 10302897 10302903 7 + 0.802 0.740 -0.250
ENSG00000115756 E004 62.5791915 0.0005979081 1.994679e-05 0.0003811661 2 10302904 10303177 274 + 1.548 1.770 0.754
ENSG00000115756 E005 0.0000000       2 10303700 10303942 243 +      
ENSG00000115756 E006 0.0000000       2 10324347 10324396 50 +      
ENSG00000115756 E007 0.0000000       2 10330163 10330210 48 +      
ENSG00000115756 E008 0.1723744 0.0439844361 1.000000e+00   2 10354216 10354381 166 + 0.001 0.070 6.496
ENSG00000115756 E009 0.0000000       2 10368678 10368737 60 +      
ENSG00000115756 E010 0.0000000       2 10368764 10369217 454 +      
ENSG00000115756 E011 1.6242356 0.0343916873 7.729603e-01 0.8804768140 2 10387761 10387810 50 + 0.339 0.381 0.248
ENSG00000115756 E012 100.5894616 0.0044306133 1.492735e-01 0.3611843077 2 10396835 10396920 86 + 1.888 1.945 0.191
ENSG00000115756 E013 0.4812263 0.0217681645 6.960861e-01   2 10406265 10406361 97 + 0.202 0.131 -0.751
ENSG00000115756 E014 20.6718953 0.0834893043 3.200716e-01 0.5598152229 2 10408562 10408734 173 + 1.378 1.220 -0.551
ENSG00000115756 E015 346.2276307 0.0007004268 8.562502e-02 0.2557170983 2 10419734 10420020 287 + 2.451 2.467 0.053
ENSG00000115756 E016 238.9301821 0.0022167168 4.224674e-02 0.1605493188 2 10420021 10420135 115 + 2.269 2.311 0.140
ENSG00000115756 E017 196.4728997 0.0002624467 1.441687e-01 0.3536239790 2 10422983 10423088 106 + 2.268 2.205 -0.210
ENSG00000115756 E018 45.6605904 0.0815541099 4.508515e-03 0.0319806524 2 10423089 10424524 1436 + 1.884 1.453 -1.465
ENSG00000115756 E019 12.9928334 0.0703705001 2.127094e-01 0.4449155167 2 10424525 10424613 89 + 1.232 1.017 -0.770
ENSG00000115756 E020 56.1915535 0.0592607659 4.397925e-03 0.0313678659 2 10424614 10425981 1368 + 1.942 1.563 -1.280
ENSG00000115756 E021 20.6852687 0.0798069805 1.626950e-02 0.0827870692 2 10426220 10426495 276 + 1.530 1.139 -1.362
ENSG00000115756 E022 570.8717189 0.0015753493 4.376257e-02 0.1645057467 2 10426724 10427692 969 + 2.668 2.685 0.057