ENSG00000115687

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000234040 ENSG00000115687 HEK293_OSMI2_6hA HEK293_TMG_6hB PASK protein_coding protein_coding 16.50498 21.98005 14.05483 1.86569 0.07249942 -0.6447588 4.9753755 5.775539 4.009279 0.3543627 0.1656937 -0.5255146 0.30820417 0.26583333 0.28536667 0.01953333 9.208387e-01 3.177287e-18 FALSE TRUE
ENST00000358649 ENSG00000115687 HEK293_OSMI2_6hA HEK293_TMG_6hB PASK protein_coding protein_coding 16.50498 21.98005 14.05483 1.86569 0.07249942 -0.6447588 2.2163601 4.085286 2.174459 1.4049407 0.3333044 -0.9066882 0.13728750 0.19903333 0.15473333 -0.04430000 9.819029e-01 3.177287e-18 FALSE TRUE
ENST00000403638 ENSG00000115687 HEK293_OSMI2_6hA HEK293_TMG_6hB PASK protein_coding protein_coding 16.50498 21.98005 14.05483 1.86569 0.07249942 -0.6447588 1.6558957 1.839325 1.657451 0.2125474 0.1848434 -0.1493545 0.10246667 0.08360000 0.11793333 0.03433333 5.316743e-01 3.177287e-18 FALSE TRUE
ENST00000472072 ENSG00000115687 HEK293_OSMI2_6hA HEK293_TMG_6hB PASK protein_coding retained_intron 16.50498 21.98005 14.05483 1.86569 0.07249942 -0.6447588 1.5403251 2.140408 1.121217 0.8918572 0.1279935 -0.9267345 0.08632083 0.09226667 0.07966667 -0.01260000 9.900929e-01 3.177287e-18 FALSE TRUE
ENST00000489256 ENSG00000115687 HEK293_OSMI2_6hA HEK293_TMG_6hB PASK protein_coding retained_intron 16.50498 21.98005 14.05483 1.86569 0.07249942 -0.6447588 3.0471193 3.338703 3.081552 0.9624036 0.1120851 -0.1152710 0.18160000 0.14703333 0.21933333 0.07230000 5.700372e-01 3.177287e-18   FALSE
ENST00000493544 ENSG00000115687 HEK293_OSMI2_6hA HEK293_TMG_6hB PASK protein_coding retained_intron 16.50498 21.98005 14.05483 1.86569 0.07249942 -0.6447588 1.0141719 1.300041 1.139735 0.5065185 0.1576946 -0.1883101 0.05959167 0.05626667 0.08100000 0.02473333 7.386675e-01 3.177287e-18 FALSE TRUE
MSTRG.20179.7 ENSG00000115687 HEK293_OSMI2_6hA HEK293_TMG_6hB PASK protein_coding   16.50498 21.98005 14.05483 1.86569 0.07249942 -0.6447588 0.8653518 2.298599 0.000000 0.2516326 0.0000000 -7.8508735 0.04819583 0.10413333 0.00000000 -0.10413333 3.177287e-18 3.177287e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115687 E001 0.1779838 0.0331001447 0.2315739091   2 241106099 241106099 1 - 0.169 0.000 -10.120
ENSG00000115687 E002 1.4386897 0.0129429437 0.9342909261 0.969290236 2 241106100 241106149 50 - 0.385 0.364 -0.122
ENSG00000115687 E003 7.0065443 0.0656426468 0.4353632922 0.655257774 2 241106150 241106294 145 - 0.959 0.844 -0.436
ENSG00000115687 E004 3.9011850 0.0202737702 0.1167327363 0.310359479 2 241106295 241106296 2 - 0.826 0.583 -1.011
ENSG00000115687 E005 43.2088602 0.0073138224 0.5894638755 0.763346706 2 241106297 241106417 121 - 1.591 1.616 0.084
ENSG00000115687 E006 187.4910790 0.0003884830 0.0645667776 0.212927681 2 241106418 241106723 306 - 2.210 2.251 0.138
ENSG00000115687 E007 136.0942527 0.0004237604 0.0260342461 0.115418310 2 241107353 241107459 107 - 2.058 2.121 0.212
ENSG00000115687 E008 68.4741546 0.0006118518 0.2441349045 0.481206802 2 241107460 241107464 5 - 1.778 1.821 0.145
ENSG00000115687 E009 90.0721841 0.0005986450 0.5329282512 0.724125582 2 241107465 241107499 35 - 1.916 1.930 0.047
ENSG00000115687 E010 128.0940802 0.0007783512 0.2225568138 0.456552785 2 241108167 241108300 134 - 2.056 2.088 0.106
ENSG00000115687 E011 25.0393619 0.1253815724 0.7618247281 0.873738685 2 241108467 241108807 341 - 1.373 1.387 0.046
ENSG00000115687 E012 35.9386942 0.0966576363 0.8135666324 0.904393107 2 241108808 241109780 973 - 1.514 1.542 0.096
ENSG00000115687 E013 141.3554587 0.0012002084 0.6510668848 0.804263550 2 241112240 241112439 200 - 2.118 2.124 0.020
ENSG00000115687 E014 38.0778550 0.0498686151 0.1318653608 0.334739999 2 241112440 241112786 347 - 1.661 1.503 -0.539
ENSG00000115687 E015 15.9856963 0.0286874596 0.1105741580 0.299935075 2 241113307 241113634 328 - 1.312 1.128 -0.652
ENSG00000115687 E016 139.3286172 0.0236063944 0.0175277996 0.087388395 2 241113635 241115021 1387 - 2.228 2.049 -0.602
ENSG00000115687 E017 28.2826397 0.0077277069 0.0116748497 0.065129032 2 241115022 241115042 21 - 1.559 1.357 -0.697
ENSG00000115687 E018 124.4744966 0.0003506903 0.1605949000 0.377661325 2 241115043 241115177 135 - 2.037 2.075 0.125
ENSG00000115687 E019 114.8647157 0.0026068892 0.0180490353 0.089198314 2 241115288 241115413 126 - 1.966 2.055 0.301
ENSG00000115687 E020 114.9131008 0.0005235293 0.0034764898 0.026202198 2 241122732 241122899 168 - 1.959 2.055 0.325
ENSG00000115687 E021 109.7178143 0.0003671924 0.0006064832 0.006633698 2 241123949 241124133 185 - 1.926 2.043 0.395
ENSG00000115687 E022 342.2735676 0.0001755678 0.6157170281 0.780803878 2 241126196 241126985 790 - 2.502 2.501 -0.003
ENSG00000115687 E023 194.7599993 0.0028949562 0.4965413621 0.698585366 2 241126986 241127451 466 - 2.250 2.262 0.040
ENSG00000115687 E024 0.1723744 0.0314392444 1.0000000000   2 241127708 241127759 52 - 0.000 0.086 10.522
ENSG00000115687 E025 123.9358808 0.0016760168 0.3597817364 0.595607594 2 241132874 241133030 157 - 2.048 2.072 0.080
ENSG00000115687 E026 49.7347427 0.1097887885 0.0866330248 0.257617695 2 241133031 241134769 1739 - 1.809 1.592 -0.733
ENSG00000115687 E027 51.1628807 0.0092417584 0.6858845726 0.826399453 2 241135871 241135875 5 - 1.674 1.690 0.057
ENSG00000115687 E028 114.0367959 0.0047867616 0.7785466601 0.883874020 2 241135876 241136039 164 - 2.028 2.031 0.011
ENSG00000115687 E029 43.1063150 0.0093460402 0.5553789789 0.740026740 2 241137004 241137006 3 - 1.651 1.598 -0.180
ENSG00000115687 E030 67.4147436 0.0039176209 0.5432799862 0.731395458 2 241137007 241137070 64 - 1.833 1.790 -0.147
ENSG00000115687 E031 82.8275368 0.0006759067 0.5665421251 0.747673210 2 241137071 241137264 194 - 1.916 1.881 -0.117
ENSG00000115687 E032 66.3238690 0.0007640503 0.6710247515 0.817007479 2 241137953 241138087 135 - 1.817 1.786 -0.104
ENSG00000115687 E033 65.6358827 0.0022410292 0.2682486322 0.507890342 2 241138654 241138751 98 - 1.838 1.772 -0.225
ENSG00000115687 E034 41.9453906 0.0008848136 0.0622427054 0.207832561 2 241138752 241138774 23 - 1.678 1.562 -0.395
ENSG00000115687 E035 38.7566046 0.0010418646 0.2872576690 0.528034108 2 241138775 241138794 20 - 1.617 1.543 -0.253
ENSG00000115687 E036 0.1723744 0.0314392444 1.0000000000   2 241139552 241139595 44 - 0.000 0.086 10.522
ENSG00000115687 E037 82.3363545 0.0005151425 0.1481705017 0.359714649 2 241139885 241140055 171 - 1.933 1.862 -0.238
ENSG00000115687 E038 54.0900236 0.0024263375 0.3435107615 0.581180852 2 241140521 241140573 53 - 1.747 1.684 -0.212
ENSG00000115687 E039 77.6500243 0.0067868913 0.7878263764 0.889301996 2 241140574 241140753 180 - 1.878 1.848 -0.098
ENSG00000115687 E040 0.1723744 0.0314392444 1.0000000000   2 241140754 241140867 114 - 0.000 0.086 10.522
ENSG00000115687 E041 91.4185130 0.0036884340 0.0408151808 0.156837081 2 241142837 241143074 238 - 2.005 1.896 -0.365
ENSG00000115687 E042 4.0474719 0.0326415498 0.0865404236 0.257490966 2 241145750 241145860 111 - 0.463 0.760 1.321
ENSG00000115687 E043 36.7637430 0.0022786987 0.0084311881 0.051295441 2 241149414 241149483 70 - 1.660 1.487 -0.590
ENSG00000115687 E044 1.3023320 0.1590231798 0.0435213134   2 241149608 241149828 221 - 0.000 0.462 12.884
ENSG00000115687 E045 2.1352719 0.1065395150 0.5069792313 0.705640017 2 241149829 241149956 128 - 0.383 0.528 0.742
ENSG00000115687 E046 3.2485414 0.0516886221 0.4952896420 0.697662962 2 241149957 241150077 121 - 0.527 0.651 0.553
ENSG00000115687 E047 5.7415689 0.1493312180 0.7766967322 0.882729476 2 241150078 241150265 188 - 0.785 0.820 0.136