ENSG00000115526

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264249 ENSG00000115526 HEK293_OSMI2_6hA HEK293_TMG_6hB CHST10 protein_coding protein_coding 23.06523 25.2772 18.09176 0.7728283 0.76218 -0.4822771 19.909868 22.3380731 13.181922 0.5230969 0.6773585 -0.7604957 0.85890833 0.88413333 0.7280667 -0.1560667 1.934171e-06 1.934171e-06 FALSE TRUE
MSTRG.18927.2 ENSG00000115526 HEK293_OSMI2_6hA HEK293_TMG_6hB CHST10 protein_coding   23.06523 25.2772 18.09176 0.7728283 0.76218 -0.4822771 1.055651 0.4788903 3.175392 0.2395945 0.3247356 2.7038879 0.05069167 0.01853333 0.1776667 0.1591333 1.317977e-01 1.934171e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115526 E001 375.736221 0.765304970 0.28333671 0.52378044 2 100391860 100392606 747 - 2.396 2.598 0.673
ENSG00000115526 E002 419.728999 0.878079182 0.38120301 0.61319995 2 100392607 100393244 638 - 2.497 2.630 0.444
ENSG00000115526 E003 127.201919 0.210585595 0.34831205 0.58576180 2 100393245 100393340 96 - 2.016 2.102 0.288
ENSG00000115526 E004 82.180653 0.073881687 0.55949085 0.74293938 2 100393341 100393348 8 - 1.860 1.903 0.142
ENSG00000115526 E005 101.090435 0.147532761 0.44873878 0.66482802 2 100393349 100393375 27 - 1.939 1.995 0.187
ENSG00000115526 E006 266.468293 0.742782738 0.51263531 0.70994244 2 100393376 100393782 407 - 2.378 2.403 0.083
ENSG00000115526 E007 103.157020 0.158897506 0.47828239 0.68596608 2 100395509 100395614 106 - 1.957 2.000 0.141
ENSG00000115526 E008 49.353971 0.001650535 0.70828307 0.84069416 2 100397908 100397910 3 - 1.658 1.676 0.061
ENSG00000115526 E009 62.414350 0.007230377 0.67860278 0.82184349 2 100397911 100397935 25 - 1.768 1.774 0.019
ENSG00000115526 E010 144.261898 0.291760133 0.47152218 0.68121219 2 100397936 100398051 116 - 2.112 2.139 0.090
ENSG00000115526 E011 99.718336 0.166449121 0.57655206 0.75480504 2 100398052 100398079 28 - 1.965 1.975 0.033
ENSG00000115526 E012 124.152915 0.238660618 0.49738037 0.69913600 2 100398080 100398142 63 - 2.050 2.073 0.077
ENSG00000115526 E013 131.345137 0.025618051 0.12319913 0.32082138 2 100402564 100402655 92 - 2.103 2.086 -0.058
ENSG00000115526 E014 123.145024 0.213084868 0.19628971 0.42491201 2 100406576 100406707 132 - 2.122 2.032 -0.301
ENSG00000115526 E015 2.881208 0.101147795 0.04171205 0.15917993 2 100407447 100407602 156 - 0.756 0.441 -1.418
ENSG00000115526 E016 1.345744 0.013297494 0.28300238   2 100407673 100407706 34 - 0.167 0.407 1.725
ENSG00000115526 E017 1.637720 0.222553665 0.72078554 0.84866566 2 100407793 100407892 100 - 0.382 0.381 -0.005
ENSG00000115526 E018 1.251032 0.174611949 0.47785492   2 100408174 100408542 369 - 0.384 0.282 -0.637
ENSG00000115526 E019 5.705154 0.007458405 0.16968994 0.39010035 2 100408543 100408660 118 - 0.632 0.870 0.967
ENSG00000115526 E020 52.874454 0.279508760 0.39554915 0.62484146 2 100415041 100415052 12 - 1.727 1.687 -0.133
ENSG00000115526 E021 69.028490 0.285479531 0.49338924 0.69620395 2 100415053 100415111 59 - 1.808 1.816 0.028
ENSG00000115526 E022 0.000000       2 100415774 100415845 72 -      
ENSG00000115526 E023 3.504211 0.041133191 0.01016401 0.05883234 2 100416223 100416525 303 - 0.850 0.477 -1.606
ENSG00000115526 E024 1.047013 0.035537472 0.46116994   2 100416723 100416847 125 - 0.382 0.274 -0.678
ENSG00000115526 E025 2.545682 0.465273043 0.31452800 0.55474218 2 100416848 100416988 141 - 0.639 0.453 -0.869
ENSG00000115526 E026 1.583230 0.421577953 0.16374289 0.38227130 2 100416989 100417070 82 - 0.526 0.290 -1.308
ENSG00000115526 E027 1.416205 0.232234192 0.63331666 0.79253486 2 100417071 100417130 60 - 0.380 0.335 -0.268
ENSG00000115526 E028 2.318558 0.479866189 0.41267923 0.63812816 2 100417131 100417255 125 - 0.582 0.450 -0.637
ENSG00000115526 E029 4.301902 0.317797915 0.36285199 0.59804355 2 100417258 100417373 116 - 0.761 0.669 -0.379
ENSG00000115526 E030 55.490069 0.350257391 0.64185949 0.79807894 2 100417374 100417668 295 - 1.698 1.731 0.111