ENSG00000115524

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335508 ENSG00000115524 HEK293_OSMI2_6hA HEK293_TMG_6hB SF3B1 protein_coding protein_coding 106.4757 34.49218 188.4457 6.303928 7.912876 2.449466 47.859296 12.4547496 87.75467 2.1560120 2.307291 2.8157865 0.40215000 0.36280000 0.46636667 0.10356667 0.0071579458 2.645265e-06 FALSE TRUE
ENST00000409915 ENSG00000115524 HEK293_OSMI2_6hA HEK293_TMG_6hB SF3B1 protein_coding nonsense_mediated_decay 106.4757 34.49218 188.4457 6.303928 7.912876 2.449466 7.965551 0.4314208 16.96420 0.3313217 1.898915 5.2650449 0.05080417 0.01213333 0.08950000 0.07736667 0.1406833699 2.645265e-06 TRUE TRUE
ENST00000424674 ENSG00000115524 HEK293_OSMI2_6hA HEK293_TMG_6hB SF3B1 protein_coding protein_coding 106.4757 34.49218 188.4457 6.303928 7.912876 2.449466 34.103356 13.4684734 57.14568 2.5563459 1.939791 2.0842398 0.34567917 0.38956667 0.30353333 -0.08603333 0.0383083697 2.645265e-06 FALSE FALSE
ENST00000479532 ENSG00000115524 HEK293_OSMI2_6hA HEK293_TMG_6hB SF3B1 protein_coding retained_intron 106.4757 34.49218 188.4457 6.303928 7.912876 2.449466 8.900406 6.7429849 11.12071 1.8033863 1.996457 0.7209479 0.14491667 0.19103333 0.05836667 -0.13266667 0.0002822036 2.645265e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115524 E001 0.4349185 2.176816e-02 4.118562e-01   2 197388515 197389783 1269 - 0.106 0.244 1.454
ENSG00000115524 E002 0.0000000       2 197389784 197389791 8 -      
ENSG00000115524 E003 722.9352553 5.384600e-03 1.408525e-03 1.296196e-02 2 197389792 197392254 2463 - 2.700 2.825 0.417
ENSG00000115524 E004 790.5260718 1.479439e-04 3.685074e-17 7.450123e-15 2 197392255 197392461 207 - 2.737 2.875 0.462
ENSG00000115524 E005 579.9421711 1.624456e-04 7.696814e-08 2.938615e-06 2 197392972 197393051 80 - 2.608 2.712 0.347
ENSG00000115524 E006 828.5454045 1.344616e-04 1.619068e-11 1.344523e-09 2 197393052 197393186 135 - 2.762 2.872 0.363
ENSG00000115524 E007 415.1747989 1.993175e-04 1.323928e-03 1.233925e-02 2 197393187 197393188 2 - 2.470 2.545 0.248
ENSG00000115524 E008 3.7778023 6.513621e-03 8.711040e-01 9.365309e-01 2 197393189 197393351 163 - 0.575 0.604 0.131
ENSG00000115524 E009 1103.6729243 9.914646e-05 9.978741e-10 5.827441e-08 2 197396056 197396328 273 - 2.892 2.978 0.286
ENSG00000115524 E010 0.2852693 2.983794e-01 1.000000e+00   2 197397954 197397984 31 - 0.104 0.000 -9.832
ENSG00000115524 E011 726.5709339 8.956951e-05 1.509498e-07 5.369658e-06 2 197397985 197398116 132 - 2.710 2.799 0.298
ENSG00000115524 E012 652.3370319 8.025877e-04 7.698898e-03 4.793018e-02 2 197398461 197398581 121 - 2.668 2.725 0.189
ENSG00000115524 E013 4.9340061 5.074031e-03 5.605688e-01 7.436906e-01 2 197398582 197398772 191 - 0.648 0.743 0.396
ENSG00000115524 E014 8.1181805 1.485540e-02 6.395803e-01 7.966455e-01 2 197398969 197399028 60 - 0.824 0.892 0.261
ENSG00000115524 E015 703.3426963 5.269942e-04 1.662494e-02 8.407422e-02 2 197400055 197400166 112 - 2.703 2.750 0.156
ENSG00000115524 E016 799.8734030 1.427171e-04 2.647905e-01 5.040930e-01 2 197400252 197400434 183 - 2.763 2.781 0.061
ENSG00000115524 E017 860.4519530 1.449376e-04 7.435820e-01 8.626974e-01 2 197400715 197400936 222 - 2.799 2.793 -0.022
ENSG00000115524 E018 619.7306947 1.161038e-04 5.470994e-01 7.342254e-01 2 197401400 197401525 126 - 2.654 2.664 0.035
ENSG00000115524 E019 615.0329628 1.199830e-04 6.740309e-01 8.189363e-01 2 197401742 197401888 147 - 2.654 2.645 -0.031
ENSG00000115524 E020 383.7674399 4.201211e-04 2.611362e-01 5.001741e-01 2 197401985 197402021 37 - 2.452 2.421 -0.103
ENSG00000115524 E021 491.7460608 1.405428e-04 1.666255e-01 3.860414e-01 2 197402022 197402130 109 - 2.560 2.528 -0.107
ENSG00000115524 E022 7.7256148 4.451735e-03 1.774221e-01 4.003290e-01 2 197402421 197402555 135 - 0.785 0.969 0.708
ENSG00000115524 E023 772.9982353 9.308956e-05 4.654795e-01 6.769237e-01 2 197402556 197402826 271 - 2.750 2.761 0.038
ENSG00000115524 E024 457.3202890 1.489744e-04 9.807471e-01 9.921335e-01 2 197402949 197403035 87 - 2.525 2.524 -0.005
ENSG00000115524 E025 570.8995025 1.257330e-04 1.466238e-01 3.573706e-01 2 197403585 197403764 180 - 2.626 2.595 -0.104
ENSG00000115524 E026 432.0708470 2.193363e-04 1.240299e-02 6.805754e-02 2 197405076 197405177 102 - 2.509 2.447 -0.209
ENSG00000115524 E027 624.8210444 1.763938e-03 1.407835e-02 7.465505e-02 2 197405275 197405472 198 - 2.671 2.599 -0.238
ENSG00000115524 E028 0.5008152 4.143115e-02 1.000000e+00   2 197407936 197407997 62 - 0.151 0.000 -10.444
ENSG00000115524 E029 525.6078744 3.854834e-04 4.229429e-05 7.214286e-04 2 197407998 197408119 122 - 2.600 2.502 -0.328
ENSG00000115524 E030 664.9315688 8.257150e-04 1.129679e-03 1.088917e-02 2 197408369 197408581 213 - 2.699 2.620 -0.263
ENSG00000115524 E031 0.1426347 3.236578e-02 1.000000e+00   2 197408582 197408694 113 - 0.056 0.000 -8.855
ENSG00000115524 E032 658.6486323 7.749921e-04 1.166822e-01 3.103127e-01 2 197409770 197410007 238 - 2.689 2.651 -0.127
ENSG00000115524 E033 0.6600180 1.938749e-02 6.332833e-01   2 197416594 197416740 147 - 0.191 0.000 -10.858
ENSG00000115524 E034 416.4224984 1.342383e-03 5.472401e-01 7.343133e-01 2 197416741 197416890 150 - 2.488 2.468 -0.069
ENSG00000115524 E035 276.4103030 1.715015e-04 1.235105e-04 1.781008e-03 2 197416891 197416911 21 - 2.324 2.203 -0.404
ENSG00000115524 E036 434.7098968 7.461253e-04 2.297449e-07 7.783545e-06 2 197418509 197418588 80 - 2.523 2.375 -0.494
ENSG00000115524 E037 56.2687107 1.110210e-03 1.351368e-04 1.922377e-03 2 197418589 197418795 207 - 1.662 1.374 -0.987
ENSG00000115524 E038 24.5764065 8.925911e-02 2.874231e-01 5.281839e-01 2 197418796 197418895 100 - 1.301 1.116 -0.653
ENSG00000115524 E039 34.8602030 9.401356e-02 4.421919e-01 6.602107e-01 2 197418896 197418951 56 - 1.440 1.311 -0.447
ENSG00000115524 E040 109.3259595 1.754817e-01 3.270255e-01 5.661383e-01 2 197418952 197419640 689 - 1.926 1.781 -0.488
ENSG00000115524 E041 77.6504096 1.862474e-01 1.746707e-01 3.967192e-01 2 197419641 197420180 540 - 1.791 1.542 -0.847
ENSG00000115524 E042 43.4371878 4.986866e-02 4.489211e-02 1.673400e-01 2 197420181 197420427 247 - 1.548 1.262 -0.990
ENSG00000115524 E043 528.0434555 1.616538e-04 6.880031e-11 5.031815e-09 2 197420428 197420542 115 - 2.608 2.455 -0.511
ENSG00000115524 E044 525.6275076 7.252936e-04 1.900652e-08 8.377226e-07 2 197421029 197421133 105 - 2.606 2.456 -0.500
ENSG00000115524 E045 499.3203274 7.720143e-04 4.555733e-08 1.833772e-06 2 197423808 197423893 86 - 2.583 2.435 -0.494
ENSG00000115524 E046 433.9321435 9.676764e-04 3.043983e-08 1.278285e-06 2 197423894 197423974 81 - 2.524 2.360 -0.546
ENSG00000115524 E047 303.8373259 1.334354e-03 2.829516e-06 7.063309e-05 2 197434972 197435079 108 - 2.370 2.204 -0.554