ENSG00000115484

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394440 ENSG00000115484 HEK293_OSMI2_6hA HEK293_TMG_6hB CCT4 protein_coding protein_coding 339.7049 152.7108 480.4013 20.97779 19.3605 1.653374 30.49900 12.80937 35.84766 2.743954 1.633636 1.4839562 0.09088333 0.08173333 0.07463333 -0.00710000 9.113078e-01 3.024416e-15 FALSE TRUE
ENST00000461370 ENSG00000115484 HEK293_OSMI2_6hA HEK293_TMG_6hB CCT4 protein_coding processed_transcript 339.7049 152.7108 480.4013 20.97779 19.3605 1.653374 40.04171 52.90965 28.73003 11.628334 1.534651 -0.8807421 0.15522500 0.33810000 0.05976667 -0.27833333 3.024416e-15 3.024416e-15 FALSE FALSE
MSTRG.18473.3 ENSG00000115484 HEK293_OSMI2_6hA HEK293_TMG_6hB CCT4 protein_coding   339.7049 152.7108 480.4013 20.97779 19.3605 1.653374 100.95768 35.61221 139.89896 4.830107 8.331081 1.9736393 0.28227500 0.23610000 0.29080000 0.05470000 5.524994e-01 3.024416e-15 TRUE TRUE
MSTRG.18473.5 ENSG00000115484 HEK293_OSMI2_6hA HEK293_TMG_6hB CCT4 protein_coding   339.7049 152.7108 480.4013 20.97779 19.3605 1.653374 96.90727 33.93642 149.65750 3.993537 6.980066 2.1404297 0.28812500 0.22440000 0.31153333 0.08713333 3.311516e-02 3.024416e-15 FALSE TRUE
MSTRG.18473.8 ENSG00000115484 HEK293_OSMI2_6hA HEK293_TMG_6hB CCT4 protein_coding   339.7049 152.7108 480.4013 20.97779 19.3605 1.653374 68.06825 16.90913 120.90608 1.562141 2.845236 2.8372789 0.17434167 0.11570000 0.25206667 0.13636667 1.011284e-02 3.024416e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115484 E001 0.7201176 0.1340972166 1.000000e+00   2 61868085 61868124 40 - 0.182 0.207 0.230
ENSG00000115484 E002 44.7824582 0.0258598058 3.048850e-01 5.454634e-01 2 61868125 61868419 295 - 1.550 1.695 0.492
ENSG00000115484 E003 21.3219216 0.1325626032 4.729621e-01 6.821325e-01 2 61868420 61868429 10 - 1.246 1.368 0.426
ENSG00000115484 E004 1222.6545900 1.5883718756 4.480698e-01 6.642563e-01 2 61868430 61868706 277 - 2.929 3.209 0.930
ENSG00000115484 E005 1616.4251148 0.0287198252 8.709622e-02 2.584517e-01 2 61869440 61869553 114 - 3.087 3.256 0.561
ENSG00000115484 E006 2659.9676819 0.0034167093 5.158301e-01 7.121589e-01 2 61872082 61872316 235 - 3.327 3.410 0.274
ENSG00000115484 E007 2175.3817034 0.0120529739 5.242737e-01 7.179793e-01 2 61872458 61872581 124 - 3.252 3.286 0.113
ENSG00000115484 E008 1219.5005654 0.0100174883 2.090501e-01 4.407336e-01 2 61872582 61872588 7 - 3.008 3.011 0.008
ENSG00000115484 E009 2230.3013438 0.0118237516 1.971673e-01 4.260536e-01 2 61873002 61873112 111 - 3.271 3.271 0.003
ENSG00000115484 E010 1636.9034244 0.0117185812 3.245180e-01 5.638131e-01 2 61873197 61873291 95 - 3.133 3.148 0.049
ENSG00000115484 E011 693.8218109 0.0087114514 5.815745e-01 7.581796e-01 2 61873292 61873293 2 - 2.755 2.793 0.125
ENSG00000115484 E012 2088.2510110 0.0104511237 1.107188e-02 6.267060e-02 2 61876095 61876234 140 - 3.255 3.197 -0.191
ENSG00000115484 E013 1981.4713958 0.0067095059 4.225433e-06 9.958031e-05 2 61876920 61877052 133 - 3.243 3.126 -0.391
ENSG00000115484 E014 1490.7567835 0.0003308638 1.348916e-28 9.747959e-26 2 61877393 61877514 122 - 3.119 3.018 -0.336
ENSG00000115484 E015 1648.7615809 0.0894480632 8.041123e-01 8.986655e-01 2 61878869 61879011 143 - 3.134 3.157 0.076
ENSG00000115484 E016 1140.1787149 2.0709568311 6.462835e-01 8.010466e-01 2 61880286 61880394 109 - 2.952 3.063 0.370
ENSG00000115484 E017 1130.6655164 0.0223779961 6.038498e-01 7.727251e-01 2 61883459 61883548 90 - 2.959 3.029 0.232
ENSG00000115484 E018 1158.5821543 0.0010772800 4.926904e-02 1.778438e-01 2 61885020 61885072 53 - 2.983 3.003 0.067
ENSG00000115484 E019 1.3323997 0.2188447250 5.216286e-01   2 61886923 61887085 163 - 0.274 0.449 1.044
ENSG00000115484 E020 306.6821821 0.0260693476 1.213365e-21 4.292860e-19 2 61887948 61888257 310 - 2.014 2.896 2.942
ENSG00000115484 E021 1986.5625810 0.0068839242 2.976342e-03 2.325304e-02 2 61888381 61888676 296 - 3.172 3.355 0.607