ENSG00000115414

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323926 ENSG00000115414 HEK293_OSMI2_6hA HEK293_TMG_6hB FN1 protein_coding protein_coding 8.462945 10.28027 5.411157 2.142549 0.2244668 -0.9246078 0.2635464 0.4440472 0.0000000 0.1269391 0.0000000 -5.5047703 0.02502917 0.05076667 0.00000000 -0.05076667 0.015544052 0.002220068 FALSE TRUE
ENST00000336916 ENSG00000115414 HEK293_OSMI2_6hA HEK293_TMG_6hB FN1 protein_coding protein_coding 8.462945 10.28027 5.411157 2.142549 0.2244668 -0.9246078 0.2240864 0.0000000 0.4052146 0.0000000 0.2584037 5.3757854 0.03199167 0.00000000 0.07250000 0.07250000 0.233135511 0.002220068 FALSE TRUE
ENST00000354785 ENSG00000115414 HEK293_OSMI2_6hA HEK293_TMG_6hB FN1 protein_coding protein_coding 8.462945 10.28027 5.411157 2.142549 0.2244668 -0.9246078 1.4097826 0.9455740 1.7906543 0.1487597 0.2161408 0.9140818 0.19281667 0.09723333 0.33480000 0.23756667 0.002220068 0.002220068 FALSE TRUE
ENST00000443816 ENSG00000115414 HEK293_OSMI2_6hA HEK293_TMG_6hB FN1 protein_coding protein_coding 8.462945 10.28027 5.411157 2.142549 0.2244668 -0.9246078 0.3513854 0.0000000 0.4780741 0.0000000 0.4780741 5.6090284 0.04915417 0.00000000 0.08916667 0.08916667 0.812627398 0.002220068 FALSE TRUE
ENST00000446046 ENSG00000115414 HEK293_OSMI2_6hA HEK293_TMG_6hB FN1 protein_coding protein_coding 8.462945 10.28027 5.411157 2.142549 0.2244668 -0.9246078 2.3894982 3.2707494 1.1883031 0.6263530 0.3175914 -1.4530325 0.28691250 0.32126667 0.22323333 -0.09803333 0.642786971 0.002220068 FALSE TRUE
ENST00000456923 ENSG00000115414 HEK293_OSMI2_6hA HEK293_TMG_6hB FN1 protein_coding protein_coding 8.462945 10.28027 5.411157 2.142549 0.2244668 -0.9246078 2.2303439 3.8625647 0.4920575 0.7845118 0.2757428 -2.9473648 0.24269167 0.37933333 0.08910000 -0.29023333 0.312228080 0.002220068 FALSE TRUE
ENST00000461974 ENSG00000115414 HEK293_OSMI2_6hA HEK293_TMG_6hB FN1 protein_coding retained_intron 8.462945 10.28027 5.411157 2.142549 0.2244668 -0.9246078 0.5448772 1.4290366 0.5787697 0.7347011 0.2899318 -1.2893281 0.06126667 0.11493333 0.10383333 -0.01110000 1.000000000 0.002220068   FALSE
ENST00000494446 ENSG00000115414 HEK293_OSMI2_6hA HEK293_TMG_6hB FN1 protein_coding retained_intron 8.462945 10.28027 5.411157 2.142549 0.2244668 -0.9246078 0.6828144 0.0000000 0.0000000 0.0000000 0.0000000 0.0000000 0.06288333 0.00000000 0.00000000 0.00000000   0.002220068 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115414 E001 0.3088520 0.0265912823 6.220999e-01   2 215360440 215360453 14 - 0.162 0.090 -0.976
ENSG00000115414 E002 0.3088520 0.0265912823 6.220999e-01   2 215360454 215360457 4 - 0.162 0.090 -0.976
ENSG00000115414 E003 2.1222904 0.2241773510 5.876819e-01 7.621082e-01 2 215360458 215360861 404 - 0.579 0.411 -0.825
ENSG00000115414 E004 0.8453763 0.0170680298 7.762610e-01   2 215360862 215360864 3 - 0.280 0.228 -0.387
ENSG00000115414 E005 0.8453763 0.0170680298 7.762610e-01   2 215360865 215360865 1 - 0.280 0.228 -0.387
ENSG00000115414 E006 47.7425408 0.0050007707 1.076701e-02 6.139568e-02 2 215360866 215361146 281 - 1.547 1.714 0.567
ENSG00000115414 E007 76.6392909 0.0009195327 1.091078e-05 2.264497e-04 2 215361147 215361340 194 - 1.724 1.926 0.682
ENSG00000115414 E008 101.0800386 0.0005141493 7.410080e-07 2.188525e-05 2 215361341 215361626 286 - 1.846 2.041 0.655
ENSG00000115414 E009 65.8735475 0.0006228957 2.521663e-03 2.047411e-02 2 215361969 215362079 111 - 1.697 1.841 0.487
ENSG00000115414 E010 1.2402774 1.0868507638 4.092376e-01   2 215362080 215363640 1561 - 0.594 0.092 -3.639
ENSG00000115414 E011 0.1308682 0.0326491905 9.247951e-01   2 215364370 215364666 297 - 0.000 0.090 10.971
ENSG00000115414 E012 0.3088520 0.0265912823 6.220999e-01   2 215364667 215364878 212 - 0.162 0.090 -0.976
ENSG00000115414 E013 73.7300740 0.0005413873 1.439989e-04 2.027891e-03 2 215364879 215364985 107 - 1.724 1.897 0.583
ENSG00000115414 E014 92.3058073 0.0056737469 3.531743e-02 1.424127e-01 2 215365505 215365630 126 - 1.861 1.974 0.381
ENSG00000115414 E015 0.0000000       2 215365631 215365753 123 -      
ENSG00000115414 E016 0.1779838 0.0343671969 2.532509e-01   2 215367679 215367862 184 - 0.162 0.000 -12.955
ENSG00000115414 E017 104.8468270 0.0006986582 1.497928e-04 2.095409e-03 2 215367863 215368027 165 - 1.894 2.041 0.495
ENSG00000115414 E018 59.3941474 0.0007622233 6.383544e-03 4.160882e-02 2 215370294 215370342 49 - 1.660 1.797 0.464
ENSG00000115414 E019 51.7059681 0.0008461940 8.731429e-03 5.262813e-02 2 215370343 215370379 37 - 1.600 1.741 0.478
ENSG00000115414 E020 46.3460474 0.0107565026 3.867698e-02 1.512994e-01 2 215370380 215370432 53 - 1.536 1.700 0.558
ENSG00000115414 E021 0.2027342 0.0334535575 9.241614e-01   2 215370433 215370520 88 - 0.000 0.090 10.978
ENSG00000115414 E022 0.0000000       2 215371864 215371908 45 -      
ENSG00000115414 E023 66.7011842 0.0015486315 3.428080e-03 2.592363e-02 2 215371909 215372015 107 - 1.701 1.848 0.497
ENSG00000115414 E024 17.1288443 0.0320384135 9.916442e-01 9.975701e-01 2 215372016 215372108 93 - 1.238 1.226 -0.043
ENSG00000115414 E025 76.2643535 0.0006261117 3.443935e-01 5.819847e-01 2 215372109 215372300 192 - 1.832 1.872 0.136
ENSG00000115414 E026 40.7173224 0.0009326735 9.447276e-01 9.746874e-01 2 215372301 215372375 75 - 1.591 1.594 0.011
ENSG00000115414 E027 0.9335208 0.0158629320 1.364304e-02   2 215372376 215372482 107 - 0.513 0.090 -3.296
ENSG00000115414 E028 47.0315343 0.0009407063 5.336097e-01 7.246455e-01 2 215373322 215373411 90 - 1.629 1.662 0.112
ENSG00000115414 E029 69.1200183 0.0011867445 7.508031e-03 4.706842e-02 2 215375214 215375393 180 - 1.728 1.855 0.429
ENSG00000115414 E030 30.5422678 0.0215683170 1.124269e-01 3.031715e-01 2 215375629 215375632 4 - 1.357 1.513 0.538
ENSG00000115414 E031 51.2897370 0.0010618334 4.135099e-01 6.386636e-01 2 215375633 215375718 86 - 1.660 1.702 0.142
ENSG00000115414 E032 0.0000000       2 215375719 215375725 7 -      
ENSG00000115414 E033 78.6744419 0.0029241239 4.922868e-01 6.955141e-01 2 215376498 215376674 177 - 1.856 1.886 0.098
ENSG00000115414 E034 57.3627839 0.0007379598 4.387049e-01 6.577825e-01 2 215378175 215378262 88 - 1.713 1.750 0.127
ENSG00000115414 E035 50.2024818 0.0161894293 8.252643e-01 9.110810e-01 2 215379130 215379204 75 - 1.673 1.684 0.039
ENSG00000115414 E036 55.4628063 0.0367395141 6.707585e-01 8.168243e-01 2 215379205 215379317 113 - 1.706 1.733 0.093
ENSG00000115414 E037 1.2123026 0.2632297960 7.980346e-01   2 215379318 215380810 1493 - 0.378 0.286 -0.574
ENSG00000115414 E038 67.9615139 0.0030496926 7.416227e-01 8.614541e-01 2 215380811 215381080 270 - 1.803 1.818 0.053
ENSG00000115414 E039 0.3447487 0.6343164573 6.111291e-01   2 215381081 215382002 922 - 0.000 0.168 12.008
ENSG00000115414 E040 0.0000000       2 215382003 215382048 46 -      
ENSG00000115414 E041 0.0000000       2 215382049 215382158 110 -      
ENSG00000115414 E042 0.0000000       2 215382159 215382211 53 -      
ENSG00000115414 E043 42.0927871 0.0015354580 6.094373e-01 7.765283e-01 2 215382212 215382325 114 - 1.595 1.625 0.100
ENSG00000115414 E044 51.9181348 0.0011631448 3.693485e-01 6.035493e-01 2 215383328 215383483 156 - 1.669 1.716 0.162
ENSG00000115414 E045 53.0878686 0.0007874157 6.561350e-01 8.074446e-01 2 215384020 215384184 165 - 1.689 1.711 0.075
ENSG00000115414 E046 7.0900280 0.0045347901 6.596564e-01 8.097731e-01 2 215384185 215384859 675 - 0.915 0.859 -0.215
ENSG00000115414 E047 41.9865589 0.0010154166 3.848220e-01 6.163503e-01 2 215384860 215384976 117 - 1.638 1.589 -0.169
ENSG00000115414 E048 66.6720698 0.0005893380 8.141489e-01 9.047246e-01 2 215386689 215386958 270 - 1.811 1.799 -0.040
ENSG00000115414 E049 34.7864732 0.0013565019 3.595892e-01 5.954862e-01 2 215388212 215388301 90 - 1.489 1.545 0.195
ENSG00000115414 E050 44.6515785 0.0010754254 5.790311e-01 7.565301e-01 2 215391632 215391814 183 - 1.610 1.640 0.102
ENSG00000115414 E051 0.2617363 0.1132601900 4.875880e-01   2 215391815 215392930 1116 - 0.000 0.163 11.953
ENSG00000115414 E052 26.5826773 0.0015023958 9.908454e-01 9.971618e-01 2 215392931 215393203 273 - 1.420 1.420 0.000
ENSG00000115414 E053 0.2027342 0.0334535575 9.241614e-01   2 215393204 215393721 518 - 0.000 0.090 10.978
ENSG00000115414 E054 47.5102191 0.0007319454 6.364534e-02 2.109274e-01 2 215394528 215394719 192 - 1.724 1.626 -0.334
ENSG00000115414 E055 28.1450917 0.0013439212 1.299235e-01 3.317147e-01 2 215397137 215397223 87 - 1.501 1.397 -0.358
ENSG00000115414 E056 43.0832849 0.0008495903 1.259174e-03 1.185611e-02 2 215397680 215397848 169 - 1.728 1.551 -0.601
ENSG00000115414 E057 30.5124687 0.0011778060 8.106636e-03 4.981341e-02 2 215399257 215399351 95 - 1.580 1.409 -0.587
ENSG00000115414 E058 44.5916441 0.0049625117 4.630831e-01 6.752370e-01 2 215404389 215404655 267 - 1.663 1.615 -0.164
ENSG00000115414 E059 43.9253716 0.0093653573 7.856420e-01 8.879173e-01 2 215406238 215406510 273 - 1.641 1.625 -0.055
ENSG00000115414 E060 42.4335907 0.0051436252 1.486054e-03 1.351503e-02 2 215407127 215407321 195 - 1.741 1.538 -0.689
ENSG00000115414 E061 27.8454478 0.0111958271 2.670492e-03 2.140306e-02 2 215408108 215408197 90 - 1.590 1.340 -0.860
ENSG00000115414 E062 15.7432758 0.0021567705 2.789141e-03 2.211953e-02 2 215408298 215408318 21 - 1.356 1.098 -0.913
ENSG00000115414 E063 30.5657020 0.0036566191 2.530341e-03 2.052984e-02 2 215408319 215408426 108 - 1.605 1.397 -0.714
ENSG00000115414 E064 37.8922499 0.0029560467 8.861138e-02 2.612045e-01 2 215409563 215409739 177 - 1.638 1.530 -0.369
ENSG00000115414 E065 0.1779838 0.0343671969 2.532509e-01   2 215409740 215409933 194 - 0.162 0.000 -12.955
ENSG00000115414 E066 35.6479232 0.0018947488 1.505488e-01 3.630853e-01 2 215409934 215410114 181 - 1.596 1.504 -0.314
ENSG00000115414 E067 0.3032425 0.0274424043 4.504692e-01   2 215414661 215414836 176 - 0.000 0.164 11.973
ENSG00000115414 E068 30.4299606 0.0057022735 2.402036e-01 4.767972e-01 2 215414837 215414958 122 - 1.530 1.440 -0.310
ENSG00000115414 E069 17.5599212 0.0026490286 2.998312e-01 5.402580e-01 2 215419242 215419288 47 - 1.300 1.210 -0.317
ENSG00000115414 E070 27.6585273 0.0015612873 1.207924e-01 3.171065e-01 2 215419289 215419385 97 - 1.501 1.393 -0.372
ENSG00000115414 E071 33.3208287 0.0012427050 9.408192e-03 5.556733e-02 2 215420673 215420801 129 - 1.615 1.453 -0.553
ENSG00000115414 E072 0.1779838 0.0343671969 2.532509e-01   2 215420802 215421270 469 - 0.162 0.000 -12.955
ENSG00000115414 E073 35.4100914 0.0012078467 6.210919e-05 1.002144e-03 2 215422091 215422243 153 - 1.685 1.446 -0.816
ENSG00000115414 E074 40.0016670 0.0092806448 1.451835e-04 2.041863e-03 2 215423350 215423526 177 - 1.753 1.483 -0.919
ENSG00000115414 E075 40.2175260 0.0009127940 6.195774e-05 1.000124e-03 2 215424146 215424325 180 - 1.728 1.503 -0.765
ENSG00000115414 E076 34.9456192 0.0011557844 2.523542e-02 1.129115e-01 2 215425094 215425285 192 - 1.620 1.484 -0.465
ENSG00000115414 E077 31.1981960 0.0052152109 9.712825e-03 5.687601e-02 2 215428180 215428338 159 - 1.601 1.422 -0.614
ENSG00000115414 E078 30.7278602 0.0012395087 8.309263e-04 8.531463e-03 2 215430715 215430852 138 - 1.610 1.397 -0.732
ENSG00000115414 E079 29.0343624 0.0184015292 1.470142e-01 3.580231e-01 2 215431833 215431964 132 - 1.542 1.404 -0.475
ENSG00000115414 E080 27.8707051 0.0223390356 1.829721e-02 9.001670e-02 2 215433324 215433461 138 - 1.579 1.347 -0.798
ENSG00000115414 E081 23.0091316 0.0018946871 6.180794e-05 9.981371e-04 2 215434696 215434824 129 - 1.531 1.239 -1.013
ENSG00000115414 E082 27.1248699 0.0015650726 3.716290e-02 1.473492e-01 2 215435655 215436073 419 - 1.519 1.376 -0.493