ENSG00000115306

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333896 ENSG00000115306 HEK293_OSMI2_6hA HEK293_TMG_6hB SPTBN1 protein_coding protein_coding 23.34399 23.00445 27.03851 4.317931 0.5997829 0.2330088 4.486306 2.970054 6.720951 0.5170897 0.2706768 1.1754721 0.1795333 0.1312667 0.2483667 0.117100000 0.001085729 0.001085729 FALSE TRUE
ENST00000356805 ENSG00000115306 HEK293_OSMI2_6hA HEK293_TMG_6hB SPTBN1 protein_coding protein_coding 23.34399 23.00445 27.03851 4.317931 0.5997829 0.2330088 4.342527 3.479900 5.919822 0.1715250 0.4881386 0.7648030 0.1767042 0.1663000 0.2199333 0.053633333 0.749261060 0.001085729 FALSE TRUE
MSTRG.18390.3 ENSG00000115306 HEK293_OSMI2_6hA HEK293_TMG_6hB SPTBN1 protein_coding   23.34399 23.00445 27.03851 4.317931 0.5997829 0.2330088 9.524386 12.469255 9.478761 3.5210883 1.1906236 -0.3952403 0.4213125 0.5177333 0.3493667 -0.168366667 0.395295316 0.001085729 FALSE TRUE
MSTRG.18390.8 ENSG00000115306 HEK293_OSMI2_6hA HEK293_TMG_6hB SPTBN1 protein_coding   23.34399 23.00445 27.03851 4.317931 0.5997829 0.2330088 2.649461 3.017100 3.663826 0.5872191 0.5129144 0.2793469 0.1122542 0.1320667 0.1359000 0.003833333 1.000000000 0.001085729 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115306 E001 2.3451635 0.1063921252 2.872046e-01 5.279593e-01 2 54456317 54456326 10 + 0.410 0.653 1.155
ENSG00000115306 E002 16.2855112 0.0028114371 2.809262e-01 5.211857e-01 2 54456327 54456518 192 + 1.273 1.207 -0.233
ENSG00000115306 E003 1.8216909 0.0127253567 6.054482e-01 7.738202e-01 2 54457180 54457260 81 + 0.412 0.518 0.537
ENSG00000115306 E004 1.6307231 0.1019849124 7.980225e-01 8.951953e-01 2 54457261 54457269 9 + 0.459 0.418 -0.214
ENSG00000115306 E005 0.2852693 0.2962425825 2.727794e-01   2 54457270 54457307 38 + 0.210 0.000 -11.729
ENSG00000115306 E006 0.0000000       2 54457393 54457487 95 +      
ENSG00000115306 E007 0.8323924 0.0172671820 1.633719e-01   2 54457987 54458177 191 + 0.356 0.123 -1.948
ENSG00000115306 E008 0.3206185 0.0274424043 1.963356e-01   2 54515744 54516341 598 + 0.213 0.000 -11.754
ENSG00000115306 E009 67.8853158 0.0039251631 1.821664e-04 2.473498e-03 2 54526372 54526566 195 + 1.915 1.744 -0.576
ENSG00000115306 E010 0.1779838 0.0350424174 4.813225e-01   2 54526567 54528715 2149 + 0.120 0.000 -10.756
ENSG00000115306 E011 79.3567964 0.0064014168 6.654102e-06 1.474644e-04 2 54558394 54558887 494 + 2.004 1.776 -0.768
ENSG00000115306 E012 147.9164195 0.0058387342 3.887801e-06 9.274310e-05 2 54599092 54599243 152 + 2.259 2.062 -0.660
ENSG00000115306 E013 172.6268465 0.0062041583 7.319248e-08 2.808352e-06 2 54612161 54612334 174 + 2.339 2.107 -0.777
ENSG00000115306 E014 128.4445485 0.0003054019 5.528069e-18 1.277270e-15 2 54616207 54616298 92 + 2.219 1.968 -0.838
ENSG00000115306 E015 122.2302906 0.0026527159 3.346472e-10 2.125310e-08 2 54617608 54617688 81 + 2.191 1.963 -0.763
ENSG00000115306 E016 159.0792794 0.0007854796 1.064850e-09 6.184541e-08 2 54618078 54618193 116 + 2.278 2.118 -0.534
ENSG00000115306 E017 160.4437675 0.0002819709 7.428251e-13 7.786962e-11 2 54621400 54621512 113 + 2.288 2.111 -0.593
ENSG00000115306 E018 232.8163164 0.0003380056 6.974507e-21 2.269026e-18 2 54622300 54622487 188 + 2.456 2.253 -0.676
ENSG00000115306 E019 197.9635995 0.0006664502 6.442321e-16 1.111844e-13 2 54623479 54623596 118 + 2.386 2.188 -0.660
ENSG00000115306 E020 229.1447707 0.0023219498 4.101998e-08 1.669735e-06 2 54624804 54624962 159 + 2.434 2.279 -0.514
ENSG00000115306 E021 276.0363274 0.0002729538 5.465192e-15 8.323905e-13 2 54625932 54626234 303 + 2.510 2.363 -0.490
ENSG00000115306 E022 174.0181325 0.0024640148 2.690730e-04 3.417965e-03 2 54628097 54628250 154 + 2.290 2.184 -0.353
ENSG00000115306 E023 538.7622477 0.0023509809 6.933434e-03 4.433362e-02 2 54628933 54629803 871 + 2.755 2.706 -0.163
ENSG00000115306 E024 213.0844182 0.0021855906 1.209213e-02 6.682248e-02 2 54629892 54630029 138 + 2.355 2.298 -0.189
ENSG00000115306 E025 622.4656619 0.0001597779 3.725009e-06 8.926093e-05 2 54630855 54631611 757 + 2.815 2.774 -0.133
ENSG00000115306 E026 322.3285347 0.0001694981 7.563265e-04 7.910815e-03 2 54632566 54632768 203 + 2.529 2.489 -0.132
ENSG00000115306 E027 235.3543165 0.0031376282 9.511892e-03 5.602199e-02 2 54637713 54637803 91 + 2.402 2.337 -0.216
ENSG00000115306 E028 256.9009880 0.0011882373 1.492449e-02 7.781052e-02 2 54642983 54643129 147 + 2.427 2.389 -0.129
ENSG00000115306 E029 350.1361510 0.0001687185 1.963579e-01 4.250058e-01 2 54644323 54644586 264 + 2.544 2.547 0.012
ENSG00000115306 E030 0.0000000       2 54644587 54644590 4 +      
ENSG00000115306 E031 0.0000000       2 54645157 54645158 2 +      
ENSG00000115306 E032 322.4958206 0.0001971722 1.861092e-01 4.119462e-01 2 54645229 54645453 225 + 2.510 2.512 0.006
ENSG00000115306 E033 210.3677492 0.0002247999 3.646538e-01 5.996224e-01 2 54645928 54646017 90 + 2.322 2.327 0.019
ENSG00000115306 E034 347.5608018 0.0002044506 6.422898e-02 2.122052e-01 2 54646194 54646475 282 + 2.507 2.571 0.216
ENSG00000115306 E035 237.7050206 0.0002332886 1.096874e-02 6.223669e-02 2 54647131 54647261 131 + 2.330 2.419 0.296
ENSG00000115306 E036 332.6249854 0.0002262852 1.052529e-03 1.031412e-02 2 54648986 54649184 199 + 2.472 2.567 0.317
ENSG00000115306 E037 118.8475725 0.0004836997 1.684536e-01 3.884892e-01 2 54649185 54649190 6 + 2.039 2.113 0.250
ENSG00000115306 E038 0.1426347 0.0320874926 4.822539e-01   2 54649572 54649577 6 + 0.119 0.000 -10.753
ENSG00000115306 E039 512.0796928 0.0001364457 2.716087e-02 1.187850e-01 2 54649615 54649989 375 + 2.676 2.740 0.214
ENSG00000115306 E040 4.2074304 0.0764873520 8.724748e-01 9.372987e-01 2 54652518 54653608 1091 + 0.682 0.729 0.194
ENSG00000115306 E041 316.4174865 0.0002097908 1.457037e-02 7.650446e-02 2 54653609 54653853 245 + 2.459 2.538 0.264
ENSG00000115306 E042 279.4438969 0.0002465828 6.875453e-01 8.275101e-01 2 54655070 54655208 139 + 2.426 2.463 0.124
ENSG00000115306 E043 282.2561507 0.0001890169 3.702017e-03 2.748722e-02 2 54655914 54655998 85 + 2.402 2.493 0.304
ENSG00000115306 E044 349.0264806 0.0001641508 4.310548e-08 1.743759e-06 2 54657850 54658046 197 + 2.471 2.606 0.451
ENSG00000115306 E045 251.6550249 0.0014225127 1.031247e-05 2.154114e-04 2 54659154 54659266 113 + 2.320 2.475 0.519
ENSG00000115306 E046 189.4661171 0.0007543290 5.868164e-07 1.786251e-05 2 54659936 54659999 64 + 2.186 2.358 0.575
ENSG00000115306 E047 185.5453268 0.0117600496 9.381227e-01 9.713529e-01 2 54660000 54662308 2309 + 2.252 2.286 0.113
ENSG00000115306 E048 46.9877001 0.1116720706 5.859376e-01 7.609193e-01 2 54662901 54664452 1552 + 1.603 1.746 0.485
ENSG00000115306 E049 340.4841336 0.0649955860 2.915355e-02 1.248126e-01 2 54664453 54664691 239 + 2.373 2.652 0.927
ENSG00000115306 E050 281.9569727 0.0251531521 3.522388e-03 2.647645e-02 2 54665915 54666088 174 + 2.304 2.563 0.863
ENSG00000115306 E051 171.1212420 0.0008576062 3.164080e-07 1.034129e-05 2 54667604 54667646 43 + 2.133 2.317 0.613
ENSG00000115306 E052 1129.4318545 0.0033990982 1.110893e-16 2.110238e-14 2 54668351 54671446 3096 + 2.897 3.169 0.905