ENSG00000115170

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263640 ENSG00000115170 HEK293_OSMI2_6hA HEK293_TMG_6hB ACVR1 protein_coding protein_coding 4.776154 3.898359 6.673165 0.4931511 0.8058671 0.7739684 0.4060701 0.5267788 0.0000000 0.3422475 0.0000000 -5.74625575 0.1006792 0.1348000 0.0000000 -0.13480000 2.809534e-01 1.782547e-06 FALSE TRUE
ENST00000410057 ENSG00000115170 HEK293_OSMI2_6hA HEK293_TMG_6hB ACVR1 protein_coding protein_coding 4.776154 3.898359 6.673165 0.4931511 0.8058671 0.7739684 0.5154690 0.0000000 0.8404106 0.0000000 0.1227435 6.41008775 0.0881875 0.0000000 0.1310000 0.13100000 1.782547e-06 1.782547e-06 FALSE TRUE
ENST00000412025 ENSG00000115170 HEK293_OSMI2_6hA HEK293_TMG_6hB ACVR1 protein_coding protein_coding 4.776154 3.898359 6.673165 0.4931511 0.8058671 0.7739684 0.2198197 0.0000000 1.0393510 0.0000000 1.0393510 6.71335356 0.0268625 0.0000000 0.1255333 0.12553333 9.369248e-01 1.782547e-06   FALSE
ENST00000434821 ENSG00000115170 HEK293_OSMI2_6hA HEK293_TMG_6hB ACVR1 protein_coding protein_coding 4.776154 3.898359 6.673165 0.4931511 0.8058671 0.7739684 0.9220328 0.9440622 0.8927084 0.4238327 0.2878915 -0.07982344 0.1946708 0.2283667 0.1457667 -0.08260000 8.168726e-01 1.782547e-06 FALSE TRUE
ENST00000682690 ENSG00000115170 HEK293_OSMI2_6hA HEK293_TMG_6hB ACVR1 protein_coding processed_transcript 4.776154 3.898359 6.673165 0.4931511 0.8058671 0.7739684 2.3737561 1.9927714 3.6240542 0.1448486 0.1905538 0.85958219 0.5108958 0.5237667 0.5520000 0.02823333 9.617870e-01 1.782547e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115170 E001 0.0000000       2 157736251 157736443 193 -      
ENSG00000115170 E002 0.0000000       2 157736444 157736445 2 -      
ENSG00000115170 E003 0.0000000       2 157736446 157736448 3 -      
ENSG00000115170 E004 0.5352391 0.2581113373 0.40177576   2 157736449 157736460 12 - 0.114 0.300 1.733
ENSG00000115170 E005 0.8993890 0.0168402543 0.33893766   2 157736461 157736502 42 - 0.205 0.376 1.194
ENSG00000115170 E006 1.0717634 0.0146287678 0.19534913   2 157736503 157736520 18 - 0.205 0.435 1.517
ENSG00000115170 E007 18.9872329 0.0023668743 0.95769974 0.98068911 2 157736521 157736621 101 - 1.301 1.308 0.026
ENSG00000115170 E008 106.5794317 0.0024435113 0.01047581 0.06016549 2 157736622 157737315 694 - 1.983 2.079 0.321
ENSG00000115170 E009 85.6493315 0.0026660157 0.66101173 0.81054816 2 157737316 157737665 350 - 1.928 1.947 0.065
ENSG00000115170 E010 41.0974549 0.0009235306 0.43095289 0.65186572 2 157738440 157738564 125 - 1.644 1.606 -0.131
ENSG00000115170 E011 19.2053493 0.0017502734 0.19505882 0.42343697 2 157738565 157738570 6 - 1.350 1.253 -0.339
ENSG00000115170 E012 0.8923043 0.2013210145 0.59971782   2 157738571 157741654 3084 - 0.207 0.312 0.783
ENSG00000115170 E013 0.1308682 0.0326491905 0.42969019   2 157760876 157760879 4 - 0.000 0.129 11.679
ENSG00000115170 E014 42.4932240 0.0011735145 0.29231270 0.53302215 2 157760880 157761077 198 - 1.665 1.613 -0.176
ENSG00000115170 E015 0.1614157 0.0329898208 0.55542360   2 157761078 157761742 665 - 0.114 0.000 -12.083
ENSG00000115170 E016 0.0000000       2 157764127 157764437 311 -      
ENSG00000115170 E017 54.9088375 0.0007178810 0.81865451 0.90723815 2 157765921 157766196 276 - 1.749 1.742 -0.025
ENSG00000115170 E018 39.7449221 0.0014016573 0.99947199 1.00000000 2 157770368 157770514 147 - 1.607 1.610 0.008
ENSG00000115170 E019 0.1308682 0.0326491905 0.42969019   2 157770515 157771365 851 - 0.000 0.129 11.679
ENSG00000115170 E020 28.9841943 0.0014327781 0.07219178 0.22919846 2 157774088 157774187 100 - 1.526 1.413 -0.389
ENSG00000115170 E021 21.3065578 0.0018524643 0.96651391 0.98515723 2 157778131 157778149 19 - 1.350 1.350 0.000
ENSG00000115170 E022 38.4037844 0.0011297875 0.34674452 0.58431185 2 157778150 157778342 193 - 1.620 1.571 -0.167
ENSG00000115170 E023 20.3567993 0.0018031552 0.73694268 0.85855316 2 157780337 157780405 69 - 1.344 1.323 -0.076
ENSG00000115170 E024 13.5370945 0.0029547675 0.49188759 0.69525356 2 157780406 157780407 2 - 1.198 1.139 -0.210
ENSG00000115170 E025 40.2387016 0.0010877244 0.45108222 0.66639528 2 157780408 157780600 193 - 1.632 1.595 -0.128
ENSG00000115170 E026 0.0000000       2 157790132 157790237 106 -      
ENSG00000115170 E027 0.0000000       2 157792770 157792853 84 -      
ENSG00000115170 E028 14.2887740 0.0086232971 0.73416811 0.85675421 2 157799427 157799428 2 - 1.190 1.161 -0.105
ENSG00000115170 E029 22.1876320 0.0030747781 0.96005119 0.98186830 2 157799429 157799500 72 - 1.356 1.364 0.025
ENSG00000115170 E030 0.0000000       2 157806737 157806996 260 -      
ENSG00000115170 E031 1.6208620 0.0210874361 0.68562317 0.82626081 2 157818269 157818376 108 - 0.448 0.377 -0.382
ENSG00000115170 E032 0.1614157 0.0329898208 0.55542360   2 157818377 157818384 8 - 0.114 0.000 -12.083
ENSG00000115170 E033 22.0631606 0.0021127721 0.42744937 0.64906432 2 157818385 157818559 175 - 1.333 1.395 0.215
ENSG00000115170 E034 0.0000000       2 157819403 157819489 87 -      
ENSG00000115170 E035 0.9576510 0.0172671820 0.87478267   2 157826528 157826646 119 - 0.280 0.309 0.197
ENSG00000115170 E036 0.0000000       2 157838241 157838327 87 -      
ENSG00000115170 E037 0.0000000       2 157860033 157860054 22 -      
ENSG00000115170 E038 0.1308682 0.0326491905 0.42969019   2 157860055 157860179 125 - 0.000 0.129 11.679
ENSG00000115170 E039 0.0000000       2 157874864 157875111 248 -      
ENSG00000115170 E040 0.0000000       2 157875535 157875741 207 -      
ENSG00000115170 E041 0.0000000       2 157875742 157875795 54 -      
ENSG00000115170 E042 7.9296976 0.0039076752 0.06977930 0.22436543 2 157875796 157876330 535 - 0.847 1.055 0.780