ENSG00000115159

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310454 ENSG00000115159 HEK293_OSMI2_6hA HEK293_TMG_6hB GPD2 protein_coding protein_coding 5.43745 1.275217 8.536321 0.2833527 0.1847961 2.733291 0.88707272 0.1174750 1.458642 0.06730439 0.4992257 3.526197 0.11817500 0.08133333 0.1694333 0.0881000 7.509772e-01 4.993363e-21 FALSE TRUE
ENST00000409674 ENSG00000115159 HEK293_OSMI2_6hA HEK293_TMG_6hB GPD2 protein_coding protein_coding 5.43745 1.275217 8.536321 0.2833527 0.1847961 2.733291 0.08644743 0.2456076 0.000000 0.24560757 0.0000000 -4.675859 0.05740417 0.14156667 0.0000000 -0.1415667 6.418791e-01 4.993363e-21 FALSE TRUE
ENST00000438166 ENSG00000115159 HEK293_OSMI2_6hA HEK293_TMG_6hB GPD2 protein_coding protein_coding 5.43745 1.275217 8.536321 0.2833527 0.1847961 2.733291 3.78885943 0.3076197 6.813437 0.15595867 0.4294465 4.425126 0.52694583 0.30980000 0.7994000 0.4896000 3.260175e-01 4.993363e-21 FALSE TRUE
ENST00000492005 ENSG00000115159 HEK293_OSMI2_6hA HEK293_TMG_6hB GPD2 protein_coding processed_transcript 5.43745 1.275217 8.536321 0.2833527 0.1847961 2.733291 0.09163713 0.0000000 0.000000 0.00000000 0.0000000 0.000000 0.06179167 0.00000000 0.0000000 0.0000000   4.993363e-21 FALSE FALSE
ENST00000496190 ENSG00000115159 HEK293_OSMI2_6hA HEK293_TMG_6hB GPD2 protein_coding processed_transcript 5.43745 1.275217 8.536321 0.2833527 0.1847961 2.733291 0.31496719 0.5373852 0.000000 0.12944815 0.0000000 -5.774485 0.18129167 0.41693333 0.0000000 -0.4169333 4.993363e-21 4.993363e-21   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115159 E001 0.0000000       2 156435290 156435409 120 +      
ENSG00000115159 E002 7.3976585 0.0626797970 7.201768e-01 8.483044e-01 2 156435441 156435804 364 + 0.762 0.675 -0.359
ENSG00000115159 E003 7.6550199 0.0037941334 1.992753e-02 9.563266e-02 2 156436379 156436426 48 + 0.798 0.285 -2.513
ENSG00000115159 E004 11.9978688 0.0028955174 2.204830e-01 4.540867e-01 2 156436427 156436484 58 + 0.948 0.750 -0.766
ENSG00000115159 E005 14.0756546 0.0026278525 2.015363e-01 4.315803e-01 2 156436485 156436513 29 + 1.010 0.816 -0.732
ENSG00000115159 E006 0.4986023 0.0348423889 1.000000e+00   2 156436514 156436615 102 + 0.126 0.000 -11.092
ENSG00000115159 E007 0.0000000       2 156473572 156473591 20 +      
ENSG00000115159 E008 0.0000000       2 156473592 156473636 45 +      
ENSG00000115159 E009 27.2795951 0.0014203229 3.788679e-03 2.795954e-02 2 156476098 156476207 110 + 1.289 0.925 -1.316
ENSG00000115159 E010 0.1308682 0.0326491905 3.755124e-02   2 156495562 156495691 130 + 0.000 0.284 12.433
ENSG00000115159 E011 36.5649889 0.0015737828 2.815026e-02 1.216985e-01 2 156496044 156496215 172 + 1.397 1.173 -0.787
ENSG00000115159 E012 0.3228314 0.3696714006 1.000000e+00   2 156501785 156501879 95 + 0.088 0.000 -9.756
ENSG00000115159 E013 0.0000000       2 156501880 156501881 2 +      
ENSG00000115159 E014 13.6571708 0.0032775667 4.134689e-01 6.386484e-01 2 156510796 156510796 1 + 0.995 0.874 -0.454
ENSG00000115159 E015 27.8030287 0.0014903296 8.160020e-02 2.480594e-01 2 156510797 156510920 124 + 1.281 1.083 -0.704
ENSG00000115159 E016 23.3390821 0.0061856222 2.129465e-01 4.452246e-01 2 156512220 156512317 98 + 1.204 1.049 -0.556
ENSG00000115159 E017 31.2562303 0.0062742783 1.008834e-01 2.833804e-01 2 156513333 156513496 164 + 1.329 1.144 -0.649
ENSG00000115159 E018 34.9280586 0.0038693252 2.176141e-01 4.505496e-01 2 156549608 156549772 165 + 1.371 1.247 -0.433
ENSG00000115159 E019 33.3581777 0.0104444239 4.471401e-01 6.636023e-01 2 156550602 156550746 145 + 1.350 1.269 -0.283
ENSG00000115159 E020 36.4736329 0.0013540210 4.537531e-02 1.685132e-01 2 156557389 156557551 163 + 1.399 1.199 -0.699
ENSG00000115159 E021 22.2259529 0.0017993866 5.669143e-03 3.808199e-02 2 156557552 156557582 31 + 1.203 0.816 -1.430
ENSG00000115159 E022 41.0486809 0.0010693490 2.244145e-01 4.587013e-01 2 156568825 156568959 135 + 1.438 1.330 -0.376
ENSG00000115159 E023 56.0281313 0.0006571575 7.163937e-01 8.458724e-01 2 156569363 156569538 176 + 1.555 1.580 0.087
ENSG00000115159 E024 36.3602650 0.0018137372 7.720562e-01 8.798278e-01 2 156570087 156570218 132 + 1.373 1.399 0.089
ENSG00000115159 E025 23.5840870 0.0161374380 3.825002e-01 6.142363e-01 2 156571134 156571171 38 + 1.188 1.290 0.359
ENSG00000115159 E026 36.6940789 0.0138256359 8.849054e-01 9.438401e-01 2 156571172 156571292 121 + 1.380 1.368 -0.044
ENSG00000115159 E027 37.8141235 0.0009926748 2.277019e-01 4.626255e-01 2 156578889 156579001 113 + 1.403 1.290 -0.391
ENSG00000115159 E028 0.8048655 0.0200299533 7.947290e-01   2 156579002 156579082 81 + 0.194 0.000 -11.922
ENSG00000115159 E029 0.4842470 0.7707973434 1.000000e+00   2 156579083 156579085 3 + 0.127 0.000 -10.106
ENSG00000115159 E030 29.5501354 0.0173609479 1.325174e-01 3.357830e-01 2 156579086 156579164 79 + 1.306 1.117 -0.670
ENSG00000115159 E031 0.1426347 0.0317443194 6.794196e-01   2 156579686 156579689 4 + 0.046 0.000 -9.583
ENSG00000115159 E032 26.6303202 0.0217829551 1.110586e-01 3.007015e-01 2 156579690 156579788 99 + 1.271 1.048 -0.794
ENSG00000115159 E033 39.5745061 0.0087443236 1.836538e-01 4.086829e-01 2 156582793 156582914 122 + 1.428 1.290 -0.479
ENSG00000115159 E034 375.9488047 0.0003218716 8.518424e-17 1.643891e-14 2 156582915 156586403 3489 + 2.349 2.522 0.576
ENSG00000115159 E035 0.0000000       2 156610724 156610849 126 +      
ENSG00000115159 E036 0.4043710 0.1071004211 2.558992e-02   2 156613475 156613735 261 + 0.046 0.451 4.026