ENSG00000115145

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263904 ENSG00000115145 HEK293_OSMI2_6hA HEK293_TMG_6hB STAM2 protein_coding protein_coding 4.419497 0.7081033 8.971153 0.05571889 0.4917815 3.644637 2.1197874 0.5835369 3.8918712 0.08395670 0.1740648 2.716757 0.59780417 0.8206333 0.4385667 -0.3820667 1.743420e-01 4.632065e-05 FALSE TRUE
ENST00000463854 ENSG00000115145 HEK293_OSMI2_6hA HEK293_TMG_6hB STAM2 protein_coding retained_intron 4.419497 0.7081033 8.971153 0.05571889 0.4917815 3.644637 0.4542219 0.0000000 0.7490752 0.00000000 0.3745383 6.246171 0.06632917 0.0000000 0.0851000 0.0851000 7.154464e-01 4.632065e-05 FALSE TRUE
ENST00000482997 ENSG00000115145 HEK293_OSMI2_6hA HEK293_TMG_6hB STAM2 protein_coding retained_intron 4.419497 0.7081033 8.971153 0.05571889 0.4917815 3.644637 1.2213039 0.0000000 3.1337840 0.00000000 0.6474824 8.296358 0.18618750 0.0000000 0.3433333 0.3433333 4.632065e-05 4.632065e-05 FALSE TRUE
ENST00000489389 ENSG00000115145 HEK293_OSMI2_6hA HEK293_TMG_6hB STAM2 protein_coding retained_intron 4.419497 0.7081033 8.971153 0.05571889 0.4917815 3.644637 0.4963921 0.1245664 0.9800974 0.06241345 0.2805248 2.879252 0.12523333 0.1793667 0.1093667 -0.0700000 9.281495e-01 4.632065e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115145 E001 151.9923502 0.004493589 0.0080774989 0.049675711 2 152116801 152120431 3631 - 1.982 2.103 0.404
ENSG00000115145 E002 59.4272451 0.001046750 0.8745012716 0.938462707 2 152120432 152120802 371 - 1.594 1.612 0.060
ENSG00000115145 E003 44.6229848 0.001117237 0.6094156129 0.776512336 2 152123766 152123935 170 - 1.472 1.517 0.156
ENSG00000115145 E004 6.7095202 0.079797611 0.5762293139 0.754586112 2 152123936 152124686 751 - 0.703 0.809 0.426
ENSG00000115145 E005 1.9059049 0.469112942 0.4691308371 0.679467067 2 152126004 152126225 222 - 0.373 0.000 -11.725
ENSG00000115145 E006 32.6679503 0.002103887 0.2408351040 0.477533829 2 152126226 152126379 154 - 1.358 1.252 -0.371
ENSG00000115145 E007 0.6246688 0.019420779 1.0000000000   2 152131882 152132113 232 - 0.167 0.000 -9.809
ENSG00000115145 E008 26.1948359 0.013649350 0.4010556150 0.629142659 2 152132114 152132168 55 - 1.241 1.333 0.321
ENSG00000115145 E009 32.0494509 0.006234330 0.9160061404 0.960180920 2 152133173 152133260 88 - 1.338 1.331 -0.022
ENSG00000115145 E010 33.7586442 0.018803180 0.6134103383 0.779216646 2 152133402 152133484 83 - 1.366 1.311 -0.192
ENSG00000115145 E011 29.7389193 0.002018175 0.0138224203 0.073628960 2 152135509 152135603 95 - 1.331 1.066 -0.940
ENSG00000115145 E012 24.0104800 0.001479091 0.0005956073 0.006542126 2 152143827 152143896 70 - 1.256 0.801 -1.677
ENSG00000115145 E013 32.8676790 0.001180264 0.2187569160 0.451911006 2 152143897 152143988 92 - 1.361 1.251 -0.382
ENSG00000115145 E014 23.0529583 0.001902174 0.9768439416 0.990184551 2 152143989 152144013 25 - 1.202 1.206 0.015
ENSG00000115145 E015 0.1779838 0.034300136 0.7441133895   2 152144738 152144836 99 - 0.048 0.000 -7.838
ENSG00000115145 E016 30.4107884 0.001426690 0.7495600202 0.866491471 2 152144888 152144957 70 - 1.312 1.348 0.126
ENSG00000115145 E017 39.6214907 0.002363682 0.7310067694 0.854805064 2 152147162 152147308 147 - 1.419 1.455 0.121
ENSG00000115145 E018 28.2789437 0.006595339 0.1656279232 0.384681930 2 152148024 152148122 99 - 1.302 1.155 -0.518
ENSG00000115145 E019 21.8961972 0.004709333 0.0197337440 0.095003362 2 152148225 152148300 76 - 1.208 0.908 -1.093
ENSG00000115145 E020 21.2309073 0.001854279 0.3995953491 0.627952193 2 152150145 152150229 85 - 1.158 1.252 0.333
ENSG00000115145 E021 20.9620116 0.001794027 0.0329518805 0.135927207 2 152175603 152175763 161 - 1.132 1.348 0.760