ENSG00000115084

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000245680 ENSG00000115084 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC35F5 protein_coding protein_coding 16.09718 3.842568 29.22028 0.6187049 0.3870796 2.923571 2.83307959 0.5932460 5.3570077 0.02931263 0.15451219 3.1532997 0.17146250 0.1659000 0.18326667 0.01736667 9.234640e-01 2.845048e-13 FALSE TRUE
ENST00000420066 ENSG00000115084 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC35F5 protein_coding nonsense_mediated_decay 16.09718 3.842568 29.22028 0.6187049 0.3870796 2.923571 2.64162207 0.5517208 4.8439276 0.28416052 0.72564421 3.1112274 0.13189583 0.1247000 0.16520000 0.04050000 8.798073e-01 2.845048e-13   FALSE
ENST00000459683 ENSG00000115084 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC35F5 protein_coding retained_intron 16.09718 3.842568 29.22028 0.6187049 0.3870796 2.923571 0.71592138 0.1013593 1.0312474 0.06448679 0.04893575 3.2250187 0.05491250 0.0341000 0.03530000 0.00120000 9.241408e-01 2.845048e-13 FALSE TRUE
ENST00000469702 ENSG00000115084 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC35F5 protein_coding retained_intron 16.09718 3.842568 29.22028 0.6187049 0.3870796 2.923571 0.99909980 0.8887035 1.2552219 0.52960843 0.28786796 0.4934733 0.11433333 0.1961000 0.04316667 -0.15293333 7.893991e-01 2.845048e-13 FALSE TRUE
MSTRG.19102.1 ENSG00000115084 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC35F5 protein_coding   16.09718 3.842568 29.22028 0.6187049 0.3870796 2.923571 0.06776555 0.2301749 0.0000000 0.13195258 0.00000000 -4.5860136 0.01752083 0.0757000 0.00000000 -0.07570000 6.870529e-02 2.845048e-13 FALSE TRUE
MSTRG.19102.11 ENSG00000115084 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC35F5 protein_coding   16.09718 3.842568 29.22028 0.6187049 0.3870796 2.923571 1.79216037 0.0000000 4.5442910 0.00000000 0.39676056 8.8310827 0.07577083 0.0000000 0.15560000 0.15560000 1.619195e-10 2.845048e-13 FALSE TRUE
MSTRG.19102.4 ENSG00000115084 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC35F5 protein_coding   16.09718 3.842568 29.22028 0.6187049 0.3870796 2.923571 0.89447263 1.0422625 0.6915992 0.15986463 0.52234590 -0.5847756 0.10057083 0.2816333 0.02390000 -0.25773333 7.781803e-02 2.845048e-13 FALSE TRUE
MSTRG.19102.8 ENSG00000115084 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC35F5 protein_coding   16.09718 3.842568 29.22028 0.6187049 0.3870796 2.923571 3.78987373 0.0000000 7.4961914 0.00000000 0.68173271 9.5519373 0.17321250 0.0000000 0.25720000 0.25720000 2.845048e-13 2.845048e-13 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115084 E001 15.4267483 0.0027246892 5.594436e-25 2.836012e-22 2 113705011 113705252 242 - 0.757 1.688 3.342
ENSG00000115084 E002 4.9528011 0.0267670400 2.312609e-06 5.925381e-05 2 113705253 113705266 14 - 0.441 1.157 2.924
ENSG00000115084 E003 15.8259245 0.0212901469 8.907987e-20 2.525511e-17 2 113705267 113705548 282 - 0.738 1.718 3.518
ENSG00000115084 E004 491.6540599 0.0005711901 6.850722e-01 8.259433e-01 2 113706709 113714352 7644 - 2.505 2.501 -0.013
ENSG00000115084 E005 41.4878188 0.0184935213 2.623357e-01 5.015215e-01 2 113714353 113714646 294 - 1.457 1.331 -0.436
ENSG00000115084 E006 46.6171021 0.0007873878 3.885739e-01 6.193173e-01 2 113714647 113714750 104 - 1.502 1.439 -0.215
ENSG00000115084 E007 56.4613001 0.0016585452 3.328053e-01 5.714398e-01 2 113714751 113714862 112 - 1.582 1.516 -0.226
ENSG00000115084 E008 100.3183761 0.0005580507 3.805052e-02 1.497615e-01 2 113714863 113715041 179 - 1.830 1.718 -0.378
ENSG00000115084 E009 81.5137021 0.0006673820 3.058482e-02 1.291014e-01 2 113715042 113715157 116 - 1.742 1.610 -0.448
ENSG00000115084 E010 57.1518117 0.0006941797 5.155751e-02 1.834374e-01 2 113715158 113715195 38 - 1.595 1.453 -0.485
ENSG00000115084 E011 4.4793265 0.0057289335 7.117317e-01 8.428994e-01 2 113717453 113717752 300 - 0.583 0.656 0.320
ENSG00000115084 E012 55.8073132 0.0006765641 4.527337e-01 6.677197e-01 2 113717753 113717780 28 - 1.576 1.527 -0.166
ENSG00000115084 E013 69.7075821 0.0006072786 2.219196e-01 4.558073e-01 2 113717781 113717848 68 - 1.675 1.600 -0.253
ENSG00000115084 E014 38.9645801 0.0009942873 1.414207e-01 3.496163e-01 2 113717849 113717850 2 - 1.436 1.310 -0.436
ENSG00000115084 E015 72.1277868 0.0007789926 7.456015e-01 8.640495e-01 2 113719154 113719211 58 - 1.677 1.703 0.088
ENSG00000115084 E016 63.9526022 0.0008385773 4.075376e-01 6.341328e-01 2 113719212 113719280 69 - 1.621 1.680 0.200
ENSG00000115084 E017 46.7189206 0.0012941609 3.892878e-01 6.199365e-01 2 113719281 113719308 28 - 1.490 1.560 0.240
ENSG00000115084 E018 1.9666222 0.0656690257 6.415052e-01 7.978272e-01 2 113719309 113719711 403 - 0.339 0.443 0.585
ENSG00000115084 E019 3.0632080 0.0524238042 6.285845e-01 7.896446e-01 2 113722870 113722976 107 - 0.460 0.563 0.492
ENSG00000115084 E020 1.0347667 0.2316739481 6.131374e-01   2 113723103 113723103 1 - 0.237 0.000 -9.329
ENSG00000115084 E021 90.9014976 0.0006655600 5.903514e-01 7.639543e-01 2 113723104 113723194 91 - 1.775 1.810 0.120
ENSG00000115084 E022 106.2091195 0.0065777314 6.814811e-01 8.235935e-01 2 113725378 113725537 160 - 1.849 1.828 -0.070
ENSG00000115084 E023 0.0000000       2 113725538 113725862 325 -      
ENSG00000115084 E024 64.6411940 0.0238717715 7.496989e-01 8.665885e-01 2 113729401 113729505 105 - 1.637 1.614 -0.077
ENSG00000115084 E025 55.1587510 0.0012134386 6.976934e-01 8.340372e-01 2 113731584 113731648 65 - 1.571 1.549 -0.075
ENSG00000115084 E026 1.4015756 0.2068912983 4.660600e-01 6.772923e-01 2 113733365 113733403 39 - 0.262 0.435 1.053
ENSG00000115084 E027 71.1311758 0.0005953975 2.291415e-01 4.641234e-01 2 113734586 113734673 88 - 1.682 1.610 -0.246
ENSG00000115084 E028 74.6503595 0.0006547264 2.177361e-01 4.507183e-01 2 113735777 113735858 82 - 1.701 1.629 -0.247
ENSG00000115084 E029 0.3641499 0.0267397006 1.482143e-01   2 113741884 113741908 25 - 0.048 0.275 2.909
ENSG00000115084 E030 6.4079252 0.0046305160 5.504700e-02 1.914369e-01 2 113741909 113742599 691 - 0.657 0.952 1.170
ENSG00000115084 E031 3.9509143 0.0070833330 9.321630e-01 9.682289e-01 2 113742600 113742691 92 - 0.541 0.562 0.097
ENSG00000115084 E032 123.9798400 0.0034350803 3.030422e-01 5.435982e-01 2 113742692 113742879 188 - 1.917 1.866 -0.173
ENSG00000115084 E033 74.4115554 0.0005119423 3.498007e-01 5.870768e-01 2 113743713 113743794 82 - 1.699 1.646 -0.180
ENSG00000115084 E034 0.1614157 0.0324446239 7.493099e-01   2 113743795 113743898 104 - 0.048 0.000 -7.521
ENSG00000115084 E035 63.8304289 0.0015460104 7.498470e-01 8.667073e-01 2 113746277 113746339 63 - 1.634 1.619 -0.051
ENSG00000115084 E036 104.3191528 0.0005246554 9.889465e-01 9.962857e-01 2 113750425 113750568 144 - 1.839 1.844 0.019
ENSG00000115084 E037 110.6928388 0.0010072754 4.056663e-01 6.327982e-01 2 113755165 113755306 142 - 1.865 1.827 -0.128
ENSG00000115084 E038 78.6656456 0.0082167586 8.595581e-01 9.301241e-01 2 113755454 113755544 91 - 1.715 1.704 -0.038
ENSG00000115084 E039 12.3120004 0.0033748862 5.101079e-01 7.080498e-01 2 113755855 113756369 515 - 0.938 1.030 0.342
ENSG00000115084 E040 57.9779438 0.0009609545 1.377597e-02 7.344140e-02 2 113756370 113756693 324 - 1.562 1.725 0.554