ENSG00000114978

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396049 ENSG00000114978 HEK293_OSMI2_6hA HEK293_TMG_6hB MOB1A protein_coding protein_coding 28.24556 6.235977 49.11879 1.670342 1.455116 2.97557 21.251099 5.3467762 35.5173990 1.50357226 0.5495219 2.72949514 0.80223750 0.84536667 0.723866667 -0.12150000 1.963006e-01 1.763994e-12 FALSE TRUE
ENST00000494600 ENSG00000114978 HEK293_OSMI2_6hA HEK293_TMG_6hB MOB1A protein_coding processed_transcript 28.24556 6.235977 49.11879 1.670342 1.455116 2.97557 0.359954 0.3428156 0.3339563 0.08301993 0.1795576 -0.03668936 0.03211250 0.05766667 0.007033333 -0.05063333 1.353765e-01 1.763994e-12   FALSE
ENST00000497054 ENSG00000114978 HEK293_OSMI2_6hA HEK293_TMG_6hB MOB1A protein_coding processed_transcript 28.24556 6.235977 49.11879 1.670342 1.455116 2.97557 4.728528 0.0000000 9.3156707 0.00000000 1.4228096 9.86506368 0.09615833 0.00000000 0.188233333 0.18823333 1.763994e-12 1.763994e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000114978 E001 0.5530924 0.0430705367 4.118772e-02   2 74152528 74152601 74 - 0.054 0.412 3.578
ENSG00000114978 E002 47.7723783 0.0105975934 1.010019e-10 7.155797e-09 2 74152602 74152779 178 - 1.425 1.910 1.649
ENSG00000114978 E003 40.5846841 0.0110268273 1.333750e-09 7.605825e-08 2 74152780 74152799 20 - 1.360 1.837 1.628
ENSG00000114978 E004 81.2633465 0.0006260668 6.179750e-14 7.998961e-12 2 74152800 74152881 82 - 1.693 2.055 1.218
ENSG00000114978 E005 1900.7834158 0.0004581638 3.537795e-04 4.274932e-03 2 74152882 74156417 3536 - 3.123 3.170 0.158
ENSG00000114978 E006 284.5495647 0.0002030738 7.205237e-05 1.137424e-03 2 74156418 74156645 228 - 2.321 2.217 -0.349
ENSG00000114978 E007 6.8841776 0.0155059310 7.210260e-01 8.488087e-01 2 74158654 74158771 118 - 0.751 0.815 0.253
ENSG00000114978 E008 0.3559677 0.4853765228 1.000000e+00   2 74159069 74159090 22 - 0.104 0.001 -6.958
ENSG00000114978 E009 101.3890447 0.0003900909 7.760898e-02 2.400377e-01 2 74159091 74159108 18 - 1.873 1.801 -0.244
ENSG00000114978 E010 248.0811063 0.0002135839 2.185705e-03 1.831103e-02 2 74159109 74159254 146 - 2.260 2.178 -0.275
ENSG00000114978 E011 1.8805029 0.0186451976 1.754104e-02 8.742618e-02 2 74164022 74165217 1196 - 0.254 0.694 2.312
ENSG00000114978 E012 242.1940586 0.0002766624 5.873342e-05 9.565824e-04 2 74165218 74165351 134 - 2.254 2.137 -0.393
ENSG00000114978 E013 195.5631628 0.0003543448 3.242442e-03 2.485740e-02 2 74167014 74167107 94 - 2.159 2.067 -0.307
ENSG00000114978 E014 207.2848392 0.0003260413 3.758877e-03 2.778791e-02 2 74172586 74172675 90 - 2.183 2.095 -0.292
ENSG00000114978 E015 171.6577651 0.0005425486 2.657295e-04 3.383340e-03 2 74172676 74172749 74 - 2.106 1.973 -0.448
ENSG00000114978 E016 69.3602468 0.0005687168 4.330380e-02 1.633438e-01 2 74172750 74172752 3 - 1.715 1.606 -0.371
ENSG00000114978 E017 1.4207165 0.0140813811 3.662132e-02 1.458762e-01 2 74178008 74178114 107 - 0.220 0.618 2.252
ENSG00000114978 E018 3.4767504 0.1564306021 1.790802e-02 8.872921e-02 2 74178115 74178281 167 - 0.418 0.934 2.230
ENSG00000114978 E019 0.2735028 0.0274424043 2.013574e-01   2 74178282 74178314 33 - 0.054 0.252 2.573
ENSG00000114978 E020 136.6225490 0.0003743682 1.809162e-01 4.051721e-01 2 74178661 74178898 238 - 1.998 1.958 -0.137