ENSG00000114942

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000236957 ENSG00000114942 HEK293_OSMI2_6hA HEK293_TMG_6hB EEF1B2 protein_coding protein_coding 968.0333 349.5862 1240.355 32.43848 44.09995 1.827003 99.90602 46.8732 105.0387 7.736718 2.393057 1.163915 0.1060667 0.1324667 0.08476667 -0.04770000 0.02103583 0.02103583 FALSE  
ENST00000392222 ENSG00000114942 HEK293_OSMI2_6hA HEK293_TMG_6hB EEF1B2 protein_coding protein_coding 968.0333 349.5862 1240.355 32.43848 44.09995 1.827003 782.42021 258.4355 1030.9158 23.378054 43.283283 1.996008 0.8014083 0.7396333 0.83080000 0.09116667 0.02390625 0.02103583 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000114942 E001 4.350325 6.764392e-03 1.795559e-01 4.033820e-01 2 206159585 206159593 9 + 0.610 0.809 0.825
ENSG00000114942 E002 25.411325 1.405191e-03 1.738561e-03 1.528919e-02 2 206159594 206159606 13 + 1.297 1.526 0.793
ENSG00000114942 E003 67.373582 5.773913e-04 8.011630e-05 1.243087e-03 2 206159607 206159614 8 + 1.729 1.913 0.622
ENSG00000114942 E004 68.885753 5.504117e-04 1.064874e-04 1.576910e-03 2 206159615 206159616 2 + 1.739 1.919 0.605
ENSG00000114942 E005 170.694467 3.062888e-03 3.779504e-06 9.043916e-05 2 206159617 206159635 19 + 2.127 2.313 0.622
ENSG00000114942 E006 186.648242 1.896747e-03 4.331669e-06 1.016856e-04 2 206159636 206159637 2 + 2.173 2.336 0.544
ENSG00000114942 E007 400.955241 2.238111e-03 1.758726e-08 7.820690e-07 2 206159638 206159684 47 + 2.500 2.672 0.572
ENSG00000114942 E008 210.292906 9.342586e-03 4.172274e-02 1.592064e-01 2 206159685 206159872 188 + 2.238 2.357 0.395
ENSG00000114942 E009 103.937443 2.280892e-03 5.486657e-07 1.680665e-05 2 206159873 206159894 22 + 1.901 2.120 0.732
ENSG00000114942 E010 162.832522 2.847068e-04 9.753410e-07 2.780432e-05 2 206159895 206159912 18 + 2.117 2.268 0.505
ENSG00000114942 E011 1077.294434 7.060156e-04 2.859130e-01 5.265483e-01 2 206159913 206159926 14 + 2.975 2.995 0.065
ENSG00000114942 E012 1096.601816 6.673166e-04 3.391305e-01 5.772008e-01 2 206159927 206159933 7 + 2.983 3.001 0.058
ENSG00000114942 E013 1463.293143 4.117805e-04 3.871182e-01 6.182357e-01 2 206159934 206159958 25 + 3.109 3.123 0.044
ENSG00000114942 E014 2661.844022 1.719799e-04 1.097079e-02 6.224381e-02 2 206159959 206160018 60 + 3.366 3.391 0.085
ENSG00000114942 E015 2573.894070 7.709509e-05 1.734769e-01 3.951971e-01 2 206160019 206160059 41 + 3.355 3.368 0.045
ENSG00000114942 E016 4.489770 9.244790e-03 3.982786e-02 1.542878e-01 2 206160211 206160268 58 + 0.609 0.905 1.197
ENSG00000114942 E017 9.627589 1.645268e-02 3.160197e-01 5.560179e-01 2 206160311 206160486 176 + 1.009 0.876 -0.501
ENSG00000114942 E018 29.610377 1.661572e-02 5.072992e-01 7.058711e-01 2 206160557 206160587 31 + 1.417 1.475 0.198
ENSG00000114942 E019 4643.051665 2.846378e-05 1.213797e-01 3.180667e-01 2 206160588 206160710 123 + 3.611 3.622 0.037
ENSG00000114942 E020 46.952414 6.300166e-02 2.807645e-01 5.210000e-01 2 206160711 206160842 132 + 1.575 1.749 0.592
ENSG00000114942 E021 42.515420 7.352879e-02 2.206180e-01 4.542093e-01 2 206160843 206160886 44 + 1.519 1.733 0.728
ENSG00000114942 E022 128.113204 4.465014e-02 2.918606e-01 5.325352e-01 2 206160887 206161132 246 + 2.016 2.156 0.469
ENSG00000114942 E023 60.833845 3.273472e-02 8.084525e-01 9.012566e-01 2 206161133 206161190 58 + 1.729 1.758 0.099
ENSG00000114942 E024 53.399482 9.097249e-02 9.072577e-01 9.557596e-01 2 206161321 206161345 25 + 1.663 1.732 0.235
ENSG00000114942 E025 2395.522105 1.408394e-03 3.110004e-01 5.514086e-01 2 206161346 206161353 8 + 3.332 3.309 -0.076
ENSG00000114942 E026 4822.932681 7.554020e-05 2.610226e-05 4.783387e-04 2 206161354 206161472 119 + 3.637 3.611 -0.087
ENSG00000114942 E027 4401.673061 4.421687e-05 6.272650e-06 1.401066e-04 2 206162038 206162104 67 + 3.598 3.571 -0.089
ENSG00000114942 E028 32.276262 3.776432e-02 7.706835e-01 8.790604e-01 2 206162228 206162488 261 + 1.477 1.451 -0.091
ENSG00000114942 E029 4457.844803 6.543773e-05 1.431886e-05 2.860118e-04 2 206162489 206162614 126 + 3.603 3.576 -0.091
ENSG00000114942 E030 3209.862915 7.973582e-05 1.297067e-02 7.032944e-02 2 206162729 206162928 200 + 3.458 3.440 -0.060