ENSG00000114857

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000232978 ENSG00000114857 HEK293_OSMI2_6hA HEK293_TMG_6hB NKTR protein_coding protein_coding 16.10176 7.015794 30.54297 0.3515242 0.1143983 2.12058 2.918218 2.1047941 3.8871480 0.63513570 0.78594753 0.8819015 0.21484583 0.30976667 0.127100000 -0.18266667 0.4992481589 7.82529e-05 FALSE TRUE
ENST00000429888 ENSG00000114857 HEK293_OSMI2_6hA HEK293_TMG_6hB NKTR protein_coding nonsense_mediated_decay 16.10176 7.015794 30.54297 0.3515242 0.1143983 2.12058 1.492921 0.4071038 3.3468454 0.40710379 0.60399647 3.0086278 0.08110417 0.05310000 0.109733333 0.05663333 0.4330676730 7.82529e-05 FALSE TRUE
ENST00000460807 ENSG00000114857 HEK293_OSMI2_6hA HEK293_TMG_6hB NKTR protein_coding retained_intron 16.10176 7.015794 30.54297 0.3515242 0.1143983 2.12058 1.480577 0.2686422 3.9542189 0.15561541 0.09514994 3.8305510 0.06503333 0.03630000 0.129466667 0.09316667 0.2603146768 7.82529e-05 FALSE TRUE
ENST00000472127 ENSG00000114857 HEK293_OSMI2_6hA HEK293_TMG_6hB NKTR protein_coding retained_intron 16.10176 7.015794 30.54297 0.3515242 0.1143983 2.12058 1.484221 0.3329468 3.4327367 0.06888515 0.14788598 3.3274991 0.07421250 0.04690000 0.112433333 0.06553333 0.0282246805 7.82529e-05   FALSE
ENST00000490189 ENSG00000114857 HEK293_OSMI2_6hA HEK293_TMG_6hB NKTR protein_coding retained_intron 16.10176 7.015794 30.54297 0.3515242 0.1143983 2.12058 0.830685 0.4415611 0.2129987 0.04742972 0.08133775 -1.0178861 0.12731250 0.06313333 0.006966667 -0.05616667 0.0000782529 7.82529e-05   FALSE
MSTRG.22813.8 ENSG00000114857 HEK293_OSMI2_6hA HEK293_TMG_6hB NKTR protein_coding   16.10176 7.015794 30.54297 0.3515242 0.1143983 2.12058 4.645535 2.2009255 8.2469563 0.30594265 0.18213258 1.9009596 0.25858333 0.31100000 0.270033333 -0.04096667 0.7675156611 7.82529e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000114857 E001 0.0000000       3 42600067 42600083 17 +      
ENSG00000114857 E002 0.6246688 0.019226520 0.2557871516   3 42600084 42600586 503 + 0.232 0.000 -12.872
ENSG00000114857 E003 0.3040503 0.024441170 0.6751715644   3 42600587 42600597 11 + 0.131 0.000 -11.864
ENSG00000114857 E004 1.2732802 0.013481734 0.4948880749   3 42600598 42600654 57 + 0.274 0.443 1.011
ENSG00000114857 E005 1.2732802 0.013481734 0.4948880749   3 42600655 42600659 5 + 0.274 0.443 1.011
ENSG00000114857 E006 3.6518584 0.044096051 0.3882139947 0.619106917 3 42600660 42600671 12 + 0.636 0.528 -0.486
ENSG00000114857 E007 5.6227889 0.011186440 0.3642582883 0.599221521 3 42600672 42600681 10 + 0.785 0.711 -0.301
ENSG00000114857 E008 5.8313202 0.005823122 0.1530302060 0.366652716 3 42600682 42600685 4 + 0.810 0.658 -0.621
ENSG00000114857 E009 14.9768170 0.063339731 0.7216479899 0.849121964 3 42600686 42600717 32 + 1.146 1.127 -0.068
ENSG00000114857 E010 16.1242886 0.069190344 0.7721598372 0.879905119 3 42600718 42600742 25 + 1.176 1.162 -0.048
ENSG00000114857 E011 19.3888594 0.047933201 0.8462979773 0.922906448 3 42600743 42600760 18 + 1.243 1.259 0.057
ENSG00000114857 E012 18.1732098 0.085093302 0.9076792498 0.955990184 3 42600761 42600778 18 + 1.209 1.254 0.160
ENSG00000114857 E013 3.3579135 0.027202897 0.1887349319 0.415424090 3 42600779 42600979 201 + 0.636 0.442 -0.910
ENSG00000114857 E014 2.7166765 0.190862651 0.5957897017 0.767590472 3 42600980 42600983 4 + 0.553 0.440 -0.551
ENSG00000114857 E015 28.4059669 0.720373636 0.6246671558 0.787133694 3 42600984 42601064 81 + 1.387 1.439 0.179
ENSG00000114857 E016 1.4340757 0.013696863 0.2537295631 0.492070250 3 42601065 42603056 1992 + 0.274 0.527 1.424
ENSG00000114857 E017 0.1779838 0.048165120 1.0000000000   3 42611103 42611184 82 + 0.071 0.000 -10.868
ENSG00000114857 E018 36.4848017 0.059408646 0.4423109897 0.660284949 3 42617570 42617644 75 + 1.517 1.466 -0.175
ENSG00000114857 E019 47.9128907 0.025805157 0.0776166215 0.240048944 3 42619020 42619127 108 + 1.646 1.536 -0.375
ENSG00000114857 E020 8.1362462 0.004005423 0.0001746517 0.002388458 3 42619128 42619663 536 + 0.976 0.443 -2.255
ENSG00000114857 E021 35.6600885 0.026321938 0.0523557299 0.185133201 3 42619664 42619708 45 + 1.529 1.387 -0.489
ENSG00000114857 E022 6.6016393 0.010670793 0.0024800878 0.020199317 3 42619709 42619818 110 + 0.887 0.443 -1.920
ENSG00000114857 E023 10.0121511 0.046662185 0.0023267049 0.019226704 3 42619819 42620015 197 + 1.045 0.598 -1.771
ENSG00000114857 E024 16.0938706 0.002434826 0.0010225539 0.010086732 3 42620016 42620043 28 + 1.222 0.939 -1.029
ENSG00000114857 E025 30.2444071 0.127047768 0.0541476282 0.189434304 3 42620044 42621004 961 + 1.467 1.237 -0.800
ENSG00000114857 E026 9.2790113 0.048405599 0.2420001198 0.478781718 3 42621005 42621428 424 + 0.969 0.874 -0.359
ENSG00000114857 E027 30.3476274 0.370745721 0.6107795235 0.777447734 3 42621429 42621516 88 + 1.413 1.472 0.205
ENSG00000114857 E028 4.2036109 0.062406052 0.0960223463 0.274761208 3 42627186 42627199 14 + 0.705 0.443 -1.202
ENSG00000114857 E029 8.8646593 0.104754646 0.3241648995 0.563468065 3 42627200 42627227 28 + 0.947 0.878 -0.261
ENSG00000114857 E030 178.6427069 0.051736986 0.0009793711 0.009751391 3 42627228 42630545 3318 + 2.231 1.968 -0.881
ENSG00000114857 E031 25.5474235 0.018636592 0.9219426673 0.963252551 3 42630546 42630575 30 + 1.343 1.401 0.200
ENSG00000114857 E032 8.7924357 0.021675538 0.0229099200 0.105637560 3 42630576 42631032 457 + 0.976 0.710 -1.038
ENSG00000114857 E033 3.2185326 0.008945883 0.5168844928 0.712953827 3 42631033 42631170 138 + 0.582 0.527 -0.251
ENSG00000114857 E034 44.6058752 0.057446574 0.9783330750 0.990931016 3 42631171 42631316 146 + 1.581 1.623 0.142
ENSG00000114857 E035 88.5324744 0.019547041 0.1609356336 0.378184127 3 42632601 42632823 223 + 1.894 1.842 -0.176
ENSG00000114857 E036 22.6428849 0.001855795 0.0242084308 0.109719799 3 42632824 42633112 289 + 1.334 1.214 -0.423
ENSG00000114857 E037 24.3946826 0.003276446 0.0232569005 0.106770745 3 42633209 42633579 371 + 1.362 1.244 -0.414
ENSG00000114857 E038 59.0385360 0.020997121 0.1243560156 0.322666335 3 42633580 42633636 57 + 1.719 1.664 -0.186
ENSG00000114857 E039 94.1163458 0.007121138 0.0005528951 0.006155793 3 42633637 42633735 99 + 1.932 1.808 -0.417
ENSG00000114857 E040 93.2903904 0.012700524 0.0006207406 0.006756820 3 42634613 42634700 88 + 1.934 1.780 -0.520
ENSG00000114857 E041 1.6128674 0.012082975 0.6412171110 0.797649501 3 42634701 42635057 357 + 0.382 0.339 -0.253
ENSG00000114857 E042 0.5421338 0.024360293 0.7794566496   3 42635080 42635220 141 + 0.131 0.202 0.747
ENSG00000114857 E043 104.8656639 0.023313807 0.0012535648 0.011817705 3 42635221 42635366 146 + 1.989 1.808 -0.610
ENSG00000114857 E044 1.7198950 0.019090687 0.8019304328 0.897485415 3 42635367 42635481 115 + 0.349 0.444 0.527
ENSG00000114857 E045 518.7133563 0.022697207 0.0049423043 0.034322276 3 42636868 42638226 1359 + 2.664 2.568 -0.321
ENSG00000114857 E046 338.6285477 0.023874826 0.1015710858 0.284631653 3 42638227 42638906 680 + 2.465 2.440 -0.082
ENSG00000114857 E047 80.2206257 0.034286501 0.6629543060 0.811723123 3 42638907 42638987 81 + 1.827 1.870 0.145
ENSG00000114857 E048 419.4375253 0.015406902 0.8949550089 0.949194908 3 42638988 42639750 763 + 2.530 2.614 0.279
ENSG00000114857 E049 133.3838231 0.004195293 0.0238976933 0.108762876 3 42642501 42642596 96 + 2.006 2.191 0.622
ENSG00000114857 E050 98.6497454 0.002238899 0.0062999874 0.041203356 3 42643339 42643395 57 + 1.871 2.072 0.674
ENSG00000114857 E051 5.9084578 0.440569201 0.4298019539 0.650885119 3 42643652 42643898 247 + 0.764 0.815 0.203
ENSG00000114857 E052 28.6880409 0.002259672 0.2792017489 0.519354372 3 42643899 42643901 3 + 1.362 1.518 0.538
ENSG00000114857 E053 101.8108747 0.008247887 0.0108304766 0.061658198 3 42643902 42644003 102 + 1.881 2.097 0.726
ENSG00000114857 E054 780.2634016 1.200850615 0.2578757170 0.496628842 3 42645888 42649847 3960 + 2.690 3.088 1.324