ENSG00000114573

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000273398 ENSG00000114573 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP6V1A protein_coding protein_coding 37.10679 10.62607 58.87445 3.109245 1.406223 2.468921 31.63705 7.593328 57.0854 1.970525 1.273483 2.908672 0.7636042 0.7516333 0.9697 0.2180667 4.765455e-03 8.852552e-13 FALSE TRUE
ENST00000461496 ENSG00000114573 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP6V1A protein_coding processed_transcript 37.10679 10.62607 58.87445 3.109245 1.406223 2.468921 2.88574 2.755568 0.0000 1.593456 0.000000 -8.111432 0.1843792 0.2259000 0.0000 -0.2259000 8.852552e-13 8.852552e-13   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000114573 E001 4.7996711 0.0105750614 4.483108e-01 6.644975e-01 3 113746340 113746421 82 + 0.589 0.778 0.794
ENSG00000114573 E002 2.8073236 0.2531563833 7.972660e-01 8.947476e-01 3 113746904 113747029 126 + 0.451 0.549 0.473
ENSG00000114573 E003 0.7732728 0.5937190137 6.117961e-01   3 113747030 113747032 3 + 0.170 0.270 0.855
ENSG00000114573 E004 0.9760071 0.7520900120 3.823670e-01   3 113747033 113747034 2 + 0.169 0.447 1.921
ENSG00000114573 E005 1.1374228 0.3229292592 4.319073e-01   3 113747035 113747036 2 + 0.206 0.437 1.510
ENSG00000114573 E006 3.9238723 0.3416595524 2.239112e-01 4.581083e-01 3 113747037 113747041 5 + 0.498 0.876 1.604
ENSG00000114573 E007 10.7468985 0.5742487017 4.408270e-01 6.593381e-01 3 113747042 113747049 8 + 0.876 1.136 0.960
ENSG00000114573 E008 66.7787350 1.0808758515 6.408801e-01 7.974579e-01 3 113747050 113747113 64 + 1.656 1.732 0.259
ENSG00000114573 E009 0.4466850 0.0234906814 1.000000e+00   3 113747114 113747127 14 + 0.138 0.000 -12.515
ENSG00000114573 E010 84.9379566 0.1173546727 9.882137e-01 9.959154e-01 3 113778741 113778768 28 + 1.769 1.778 0.030
ENSG00000114573 E011 139.3123535 0.0216422022 3.186589e-01 5.584679e-01 3 113778769 113778835 67 + 1.985 1.972 -0.044
ENSG00000114573 E012 0.8048655 0.0200902546 4.917986e-01   3 113778836 113779168 333 + 0.211 0.000 -13.255
ENSG00000114573 E013 1.4648835 0.0136968632 1.842721e-01 4.095383e-01 3 113780732 113780783 52 + 0.328 0.000 -14.103
ENSG00000114573 E014 208.7594543 0.0072431220 8.563152e-02 2.557275e-01 3 113781050 113781162 113 + 2.160 2.145 -0.051
ENSG00000114573 E015 109.2888637 0.0008756300 7.593764e-02 2.366404e-01 3 113781163 113781178 16 + 1.883 1.874 -0.030
ENSG00000114573 E016 307.7350267 0.0055870499 2.137027e-02 1.005587e-01 3 113784224 113784438 215 + 2.328 2.306 -0.074
ENSG00000114573 E017 275.8839762 0.0001824462 8.352581e-03 5.093581e-02 3 113784696 113784833 138 + 2.278 2.278 0.000
ENSG00000114573 E018 296.1682487 0.0002119995 1.694589e-03 1.498308e-02 3 113786232 113786383 152 + 2.309 2.297 -0.043
ENSG00000114573 E019 288.3924448 0.0002308881 1.971177e-05 3.777377e-04 3 113788713 113788875 163 + 2.302 2.251 -0.171
ENSG00000114573 E020 251.9825602 0.0002159647 1.173335e-05 2.406232e-04 3 113789732 113789840 109 + 2.247 2.182 -0.215
ENSG00000114573 E021 227.5342142 0.0002108263 7.069709e-03 4.494754e-02 3 113794872 113794994 123 + 2.196 2.185 -0.035
ENSG00000114573 E022 195.0910098 0.0002374276 2.333950e-02 1.070169e-01 3 113795090 113795204 115 + 2.129 2.127 -0.007
ENSG00000114573 E023 135.7574943 0.0003982923 2.940511e-02 1.255855e-01 3 113795876 113795939 64 + 1.974 1.958 -0.054
ENSG00000114573 E024 318.0248294 0.0002162088 1.169270e-03 1.119407e-02 3 113798243 113798446 204 + 2.341 2.328 -0.042
ENSG00000114573 E025 0.0000000       3 113801139 113801167 29 +      
ENSG00000114573 E026 0.1723744 0.1202556624 6.918018e-02   3 113802758 113802825 68 + 0.000 0.263 16.364
ENSG00000114573 E027 0.0000000       3 113803302 113803344 43 +      
ENSG00000114573 E028 251.9980948 0.0012813452 2.137832e-03 1.799698e-02 3 113803583 113803677 95 + 2.241 2.208 -0.110
ENSG00000114573 E029 333.1882787 0.0002561505 9.812068e-02 2.784850e-01 3 113805354 113805525 172 + 2.353 2.387 0.114
ENSG00000114573 E030 2134.1290858 0.0074366306 3.112198e-06 7.671855e-05 3 113809335 113812056 2722 + 3.128 3.336 0.690