ENSG00000114554

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393409 ENSG00000114554 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNA1 protein_coding protein_coding 27.68681 40.58715 13.75108 3.143542 0.5212693 -1.560784 2.298963 1.671971 1.128505 0.3057819 0.3593500 -0.5630117 0.0950375 0.04083333 0.0836 0.04276667 6.244431e-01 5.688574e-19 FALSE TRUE
ENST00000505278 ENSG00000114554 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNA1 protein_coding processed_transcript 27.68681 40.58715 13.75108 3.143542 0.5212693 -1.560784 7.502252 11.980117 0.000000 1.8710625 0.0000000 -10.2276300 0.2049792 0.29480000 0.0000 -0.29480000 5.688574e-19 5.688574e-19 FALSE FALSE
MSTRG.23618.2 ENSG00000114554 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNA1 protein_coding   27.68681 40.58715 13.75108 3.143542 0.5212693 -1.560784 16.660699 24.990709 12.137907 1.9966975 0.5904078 -1.0412612 0.6570667 0.61610000 0.8823 0.26620000 7.459426e-06 5.688574e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000114554 E001 0.1723744 0.0328246954 1.000000e+00   3 126982693 126982709 17 + 0.000 0.078 13.531
ENSG00000114554 E002 0.4929928 0.0217681645 1.416257e-01   3 126982710 126982740 31 + 0.313 0.078 -2.419
ENSG00000114554 E003 5.8285321 0.0052960303 1.137618e-01 3.054058e-01 3 126983115 126983287 173 + 0.924 0.743 -0.705
ENSG00000114554 E004 481.6576311 0.0003515383 1.942739e-10 1.294318e-08 3 126988521 126989787 1267 + 2.698 2.609 -0.296
ENSG00000114554 E005 165.9013024 0.0004235694 9.104992e-03 5.429203e-02 3 126991384 126991566 183 + 2.208 2.159 -0.164
ENSG00000114554 E006 141.8843299 0.0004112818 1.407524e-01 3.486689e-01 3 127003330 127003470 141 + 2.119 2.101 -0.058
ENSG00000114554 E007 103.2065358 0.0003798871 5.714908e-01 7.513701e-01 3 127004611 127004711 101 + 1.963 1.973 0.035
ENSG00000114554 E008 103.7124752 0.0013282887 9.627937e-02 2.752231e-01 3 127004885 127005008 124 + 1.999 1.963 -0.119
ENSG00000114554 E009 139.4621203 0.0053029759 7.715908e-02 2.391054e-01 3 127005090 127005243 154 + 2.135 2.086 -0.164
ENSG00000114554 E010 133.3029268 0.0060569990 8.138430e-02 2.475804e-01 3 127006079 127006178 100 + 2.117 2.064 -0.175
ENSG00000114554 E011 147.0236549 0.0017642175 3.412612e-02 1.391954e-01 3 127007799 127007913 115 + 2.156 2.109 -0.158
ENSG00000114554 E012 207.0881371 0.0036494185 1.084706e-01 2.964738e-01 3 127011958 127012158 201 + 2.291 2.259 -0.108
ENSG00000114554 E013 125.7902021 0.0003268840 6.416766e-01 7.979335e-01 3 127014020 127014116 97 + 2.019 2.068 0.166
ENSG00000114554 E014 146.0219643 0.0004611443 2.729882e-01 5.128300e-01 3 127014182 127014375 194 + 2.067 2.137 0.235
ENSG00000114554 E015 156.0396004 0.0003362246 5.285957e-01 7.210199e-01 3 127014478 127014629 152 + 2.110 2.163 0.178
ENSG00000114554 E016 147.9957776 0.0002990989 6.134051e-01 7.792162e-01 3 127014711 127014831 121 + 2.088 2.137 0.166
ENSG00000114554 E017 170.5737979 0.0002952628 5.295663e-03 3.616833e-02 3 127015184 127015320 137 + 2.223 2.171 -0.174
ENSG00000114554 E018 212.8808574 0.0003090316 3.245863e-05 5.772564e-04 3 127016517 127016684 168 + 2.339 2.259 -0.267
ENSG00000114554 E019 173.1564057 0.0011150091 1.144978e-02 6.421706e-02 3 127016944 127017037 94 + 2.229 2.177 -0.176
ENSG00000114554 E020 244.3680723 0.0018673038 6.599487e-01 8.099583e-01 3 127017425 127017664 240 + 2.329 2.346 0.055
ENSG00000114554 E021 230.7391465 0.0002720454 8.940379e-02 2.626876e-01 3 127017749 127017892 144 + 2.325 2.312 -0.044
ENSG00000114554 E022 278.7645269 0.0001812524 9.692327e-03 5.679514e-02 3 127018294 127018528 235 + 2.420 2.391 -0.096
ENSG00000114554 E023 212.3457258 0.0004079826 7.053222e-02 2.257698e-01 3 127020202 127020344 143 + 2.295 2.277 -0.060
ENSG00000114554 E024 263.8248111 0.0002401824 6.640115e-03 4.290231e-02 3 127022085 127022341 257 + 2.399 2.365 -0.114
ENSG00000114554 E025 138.6954982 0.0003610167 1.157232e-01 3.087109e-01 3 127022752 127022818 67 + 2.110 2.089 -0.071
ENSG00000114554 E026 11.4406667 0.1702357388 9.222756e-01 9.634226e-01 3 127026385 127027939 1555 + 0.975 1.070 0.349
ENSG00000114554 E027 223.4800881 0.0002587130 4.761961e-02 1.740917e-01 3 127027940 127028086 147 + 2.316 2.295 -0.070
ENSG00000114554 E028 273.3104821 0.0002038651 4.636542e-02 1.709539e-01 3 127028181 127028340 160 + 2.400 2.384 -0.054
ENSG00000114554 E029 7.2800765 0.0356332087 8.971704e-01 9.504054e-01 3 127028777 127028992 216 + 0.865 0.884 0.072
ENSG00000114554 E030 198.7828303 0.0004352341 6.303736e-02 2.095270e-01 3 127028993 127029096 104 + 2.270 2.249 -0.071
ENSG00000114554 E031 203.1299370 0.0012642895 7.044922e-01 8.384480e-01 3 127029440 127029536 97 + 2.230 2.274 0.148
ENSG00000114554 E032 320.4494437 0.0002068609 1.538757e-01 3.678646e-01 3 127029874 127030064 191 + 2.409 2.474 0.218
ENSG00000114554 E033 338.4060443 0.0003507593 9.165674e-01 9.604509e-01 3 127030243 127030412 170 + 2.459 2.489 0.098
ENSG00000114554 E034 0.7796672 0.0174419221 4.904790e-01   3 127031855 127031961 107 + 0.313 0.202 -0.835
ENSG00000114554 E035 422.0244307 0.0012345184 5.605690e-01 7.436906e-01 3 127032387 127032599 213 + 2.541 2.586 0.148
ENSG00000114554 E036 315.8428075 0.0010937421 9.091584e-01 9.566429e-01 3 127032686 127032836 151 + 2.424 2.457 0.109
ENSG00000114554 E037 2511.6649600 0.0024639519 1.481584e-09 8.384106e-08 3 127033922 127037389 3468 + 3.237 3.382 0.479