ENSG00000114439

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325805 ENSG00000114439 HEK293_OSMI2_6hA HEK293_TMG_6hB BBX protein_coding protein_coding 9.298943 1.968521 17.23387 0.2861427 0.8892802 3.123589 3.6630665 0.3345481 8.4956775 0.2325400 0.3922018 4.6256489 0.28227917 0.17896667 0.49440000 0.31543333 4.020648e-01 2.850258e-11 FALSE TRUE
ENST00000415149 ENSG00000114439 HEK293_OSMI2_6hA HEK293_TMG_6hB BBX protein_coding protein_coding 9.298943 1.968521 17.23387 0.2861427 0.8892802 3.123589 2.0233198 0.0000000 3.5622593 0.0000000 0.8238306 8.4806930 0.13759167 0.00000000 0.20400000 0.20400000 1.666406e-05 2.850258e-11 FALSE TRUE
ENST00000443253 ENSG00000114439 HEK293_OSMI2_6hA HEK293_TMG_6hB BBX protein_coding protein_coding 9.298943 1.968521 17.23387 0.2861427 0.8892802 3.123589 0.4702452 0.1630632 1.1975199 0.1630632 0.3472185 2.8026763 0.07029167 0.11323333 0.06873333 -0.04450000 7.993268e-01 2.850258e-11   FALSE
ENST00000458347 ENSG00000114439 HEK293_OSMI2_6hA HEK293_TMG_6hB BBX protein_coding protein_coding 9.298943 1.968521 17.23387 0.2861427 0.8892802 3.123589 0.4428976 0.6745505 0.0000000 0.2819530 0.0000000 -6.0970850 0.22389583 0.31963333 0.00000000 -0.31963333 2.850258e-11 2.850258e-11 FALSE FALSE
MSTRG.23382.10 ENSG00000114439 HEK293_OSMI2_6hA HEK293_TMG_6hB BBX protein_coding   9.298943 1.968521 17.23387 0.2861427 0.8892802 3.123589 0.2518768 0.2464096 0.3171277 0.2464096 0.1403343 0.3514037 0.05020417 0.10170000 0.01903333 -0.08266667 1.000000e+00 2.850258e-11 FALSE TRUE
MSTRG.23382.15 ENSG00000114439 HEK293_OSMI2_6hA HEK293_TMG_6hB BBX protein_coding   9.298943 1.968521 17.23387 0.2861427 0.8892802 3.123589 0.3236606 0.3654459 0.5303463 0.2234432 0.4322757 0.5252792 0.07677917 0.20113333 0.03283333 -0.16830000 6.788475e-01 2.850258e-11 FALSE TRUE
MSTRG.23382.4 ENSG00000114439 HEK293_OSMI2_6hA HEK293_TMG_6hB BBX protein_coding   9.298943 1.968521 17.23387 0.2861427 0.8892802 3.123589 0.7104623 0.1518758 1.6446616 0.1518758 0.3132255 3.3535767 0.05268333 0.06266667 0.09746667 0.03480000 6.588897e-01 2.850258e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000114439 E001 0.0000000       3 107522936 107522960 25 +      
ENSG00000114439 E002 0.0000000       3 107522961 107522961 1 +      
ENSG00000114439 E003 0.0000000       3 107522962 107522965 4 +      
ENSG00000114439 E004 3.1819001 0.009371689 5.770362e-02 0.1976562429 3 107522966 107522985 20 + 0.450 0.000 -33.969
ENSG00000114439 E005 5.1763635 0.005319244 8.086769e-02 0.2465431672 3 107522986 107522990 5 + 0.592 0.331 -1.346
ENSG00000114439 E006 8.5340346 0.003705941 7.683606e-03 0.0478739744 3 107522991 107523002 12 + 0.765 0.331 -2.075
ENSG00000114439 E007 15.6463571 0.002727431 4.570201e-05 0.0007705772 3 107523003 107523042 40 + 0.996 0.331 -2.961
ENSG00000114439 E008 25.9413316 0.005703124 4.759582e-06 0.0001102635 3 107523043 107523107 65 + 1.194 0.646 -2.093
ENSG00000114439 E009 0.4632531 0.033839751 1.000000e+00   3 107523454 107523651 198 + 0.105 0.000 -31.225
ENSG00000114439 E010 1.1777613 0.016136089 2.209627e-01   3 107524107 107524194 88 + 0.163 0.517 2.333
ENSG00000114439 E011 0.4929928 0.030936747 2.759748e-01   3 107524357 107524567 211 + 0.073 0.331 2.654
ENSG00000114439 E012 1.0598770 0.021173734 2.105773e-02   3 107525391 107525401 11 + 0.105 0.648 3.658
ENSG00000114439 E013 2.3367415 0.209044719 1.514380e-01 0.3644173580 3 107525402 107525487 86 + 0.280 0.759 2.383
ENSG00000114439 E014 0.8267829 0.195940620 1.283037e-01   3 107525488 107525490 3 + 0.105 0.520 3.079
ENSG00000114439 E015 36.4601008 0.020752541 1.074458e-03 0.0104884576 3 107526327 107526398 72 + 1.321 1.094 -0.804
ENSG00000114439 E016 0.3206185 0.026383302 1.000000e+00   3 107526399 107526750 352 + 0.073 0.000 -30.642
ENSG00000114439 E017 0.0000000       3 107599313 107599588 276 +      
ENSG00000114439 E018 0.1426347 0.032118944 7.157814e-01   3 107638502 107638545 44 + 0.038 0.000 -29.640
ENSG00000114439 E019 0.3393995 0.028146912 1.000000e+00   3 107641791 107641864 74 + 0.073 0.000 -30.644
ENSG00000114439 E020 44.6452642 0.033903242 1.517601e-03 0.0137378738 3 107645836 107645909 74 + 1.405 1.167 -0.834
ENSG00000114439 E021 0.0000000       3 107645910 107645929 20 +      
ENSG00000114439 E022 0.0000000       3 107645930 107645932 3 +      
ENSG00000114439 E023 0.0000000       3 107645933 107645933 1 +      
ENSG00000114439 E024 0.0000000       3 107645934 107646087 154 +      
ENSG00000114439 E025 0.0000000       3 107657062 107657172 111 +      
ENSG00000114439 E026 0.0000000       3 107659568 107659770 203 +      
ENSG00000114439 E027 0.9475002 0.016000403 5.943027e-01   3 107661828 107661944 117 + 0.189 0.000 -32.227
ENSG00000114439 E028 0.1779838 0.118123746 7.237251e-01   3 107662589 107662880 292 + 0.038 0.000 -29.648
ENSG00000114439 E029 0.0000000       3 107674805 107674836 32 +      
ENSG00000114439 E030 0.0000000       3 107677427 107677470 44 +      
ENSG00000114439 E031 0.1614157 0.033102434 7.165097e-01   3 107684556 107684709 154 + 0.038 0.000 -29.642
ENSG00000114439 E032 66.6763377 0.036778397 2.522801e-02 0.1128905078 3 107710452 107710622 171 + 1.564 1.513 -0.175
ENSG00000114439 E033 0.0000000       3 107711275 107711364 90 +      
ENSG00000114439 E034 0.3040503 0.024441170 1.000000e+00   3 107716459 107716606 148 + 0.073 0.000 -30.641
ENSG00000114439 E035 74.9579163 0.026085159 1.088720e-02 0.0618898218 3 107716607 107716849 243 + 1.612 1.561 -0.176
ENSG00000114439 E036 77.9651128 0.041062992 4.481601e-02 0.1671709074 3 107728765 107728960 196 + 1.626 1.610 -0.054
ENSG00000114439 E037 45.8368648 0.069994442 1.367322e-01 0.3425021042 3 107732956 107733023 68 + 1.402 1.420 0.060
ENSG00000114439 E038 49.7693262 0.057467236 2.457243e-02 0.1109206005 3 107744630 107744710 81 + 1.444 1.347 -0.334
ENSG00000114439 E039 46.7087382 0.052533037 2.515997e-02 0.1127015539 3 107747965 107748039 75 + 1.417 1.308 -0.378
ENSG00000114439 E040 42.9635901 0.046079307 3.455038e-01 0.5831005672 3 107755598 107755678 81 + 1.367 1.467 0.346
ENSG00000114439 E041 239.5108859 0.039006008 1.795631e-02 0.0888961939 3 107772628 107773636 1009 + 2.106 2.104 -0.005
ENSG00000114439 E042 78.1495747 0.026313516 2.055412e-01 0.4365332018 3 107774719 107774857 139 + 1.618 1.718 0.338
ENSG00000114439 E043 0.0000000       3 107776205 107776349 145 +      
ENSG00000114439 E044 65.4058162 0.030783257 3.196035e-01 0.5593852268 3 107778371 107778502 132 + 1.541 1.664 0.420
ENSG00000114439 E045 40.9663529 0.028146963 6.001155e-01 0.7702865903 3 107778503 107778519 17 + 1.341 1.501 0.553
ENSG00000114439 E046 38.2685800 0.033903506 5.507958e-01 0.7368894138 3 107789787 107789876 90 + 1.314 1.456 0.492
ENSG00000114439 E047 56.6887700 0.039255151 3.683344e-01 0.6026635645 3 107791240 107791299 60 + 1.482 1.588 0.363
ENSG00000114439 E048 58.0163614 0.038763292 1.627715e-01 0.3808691549 3 107798523 107798590 68 + 1.494 1.554 0.205
ENSG00000114439 E049 36.5995968 0.026716402 1.435722e-01 0.3527620728 3 107798591 107798600 10 + 1.305 1.355 0.176
ENSG00000114439 E050 79.6082536 0.048254055 2.044562e-01 0.4351665748 3 107798601 107798711 111 + 1.628 1.708 0.272
ENSG00000114439 E051 26.4190866 0.048667561 1.847033e-02 0.0906030094 3 107798712 107798720 9 + 1.187 1.003 -0.664
ENSG00000114439 E052 66.8096277 0.019353803 1.532660e-01 0.3670276674 3 107801095 107801281 187 + 1.554 1.643 0.305
ENSG00000114439 E053 781.4255198 1.251849137 2.554002e-01 0.4940407603 3 107805370 107811339 5970 + 2.559 3.017 1.522