ENSG00000114416

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000465551 ENSG00000114416 HEK293_OSMI2_6hA HEK293_TMG_6hB FXR1 protein_coding protein_coding 63.65053 31.69286 117.7565 2.949041 5.566886 1.893244 19.266366 8.905543 38.320196 1.3905551 2.2961673 2.104087 0.29014167 0.27776667 0.3251000 0.047333333 0.6359385 0.0479046 FALSE  
ENST00000472339 ENSG00000114416 HEK293_OSMI2_6hA HEK293_TMG_6hB FXR1 protein_coding retained_intron 63.65053 31.69286 117.7565 2.949041 5.566886 1.893244 3.596957 2.030865 5.662457 0.4057084 0.2365837 1.474793 0.06462917 0.06293333 0.0481000 -0.014833333 0.7012445 0.0479046 FALSE  
ENST00000476672 ENSG00000114416 HEK293_OSMI2_6hA HEK293_TMG_6hB FXR1 protein_coding retained_intron 63.65053 31.69286 117.7565 2.949041 5.566886 1.893244 18.105418 8.785641 32.390949 0.9419595 0.9389915 1.881175 0.29657083 0.27706667 0.2756333 -0.001433333 1.0000000 0.0479046 FALSE  
ENST00000479176 ENSG00000114416 HEK293_OSMI2_6hA HEK293_TMG_6hB FXR1 protein_coding retained_intron 63.65053 31.69286 117.7565 2.949041 5.566886 1.893244 5.734561 3.177920 12.702116 0.3584590 0.4239701 1.995517 0.07235000 0.10103333 0.1080667 0.007033333 0.9383456 0.0479046 FALSE  
ENST00000481383 ENSG00000114416 HEK293_OSMI2_6hA HEK293_TMG_6hB FXR1 protein_coding retained_intron 63.65053 31.69286 117.7565 2.949041 5.566886 1.893244 3.231280 1.502977 5.982679 0.1651391 0.3413750 1.985811 0.05644583 0.04726667 0.0510000 0.003733333 0.9297821 0.0479046    
ENST00000498658 ENSG00000114416 HEK293_OSMI2_6hA HEK293_TMG_6hB FXR1 protein_coding retained_intron 63.65053 31.69286 117.7565 2.949041 5.566886 1.893244 8.893167 5.332270 13.496641 0.2988426 1.1388042 1.338144 0.14439167 0.16946667 0.1142333 -0.055233333 0.0479046 0.0479046 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000114416 E001 0.0000000       3 180868141 180868155 15 +      
ENSG00000114416 E002 0.0000000       3 180868156 180868295 140 +      
ENSG00000114416 E003 0.0000000       3 180868751 180868836 86 +      
ENSG00000114416 E004 0.7908862 0.0172671820 7.233227e-01   3 180912482 180912490 9 + 0.252 0.184 -0.577
ENSG00000114416 E005 1.1302857 0.0158132083 4.215465e-01   3 180912491 180912537 47 + 0.339 0.184 -1.163
ENSG00000114416 E006 2.8611394 0.0170321363 8.340567e-01 0.9160577709 3 180912538 180912669 132 + 0.527 0.562 0.163
ENSG00000114416 E007 2.2294560 0.1165617498 7.529614e-01 0.8685089868 3 180912670 180912670 1 + 0.445 0.500 0.276
ENSG00000114416 E008 3.5617383 0.0084338781 3.540245e-01 0.5908596376 3 180912671 180912671 1 + 0.575 0.719 0.619
ENSG00000114416 E009 6.7185421 0.0044880469 3.303846e-01 0.5693357681 3 180912672 180912677 6 + 0.800 0.925 0.480
ENSG00000114416 E010 29.2324822 0.0013173152 5.857530e-01 0.7607746298 3 180912678 180912684 7 + 1.444 1.404 -0.138
ENSG00000114416 E011 106.8998898 0.0003687562 8.140737e-01 0.9046843382 3 180912685 180912736 52 + 1.990 1.981 -0.030
ENSG00000114416 E012 1.9651333 0.0326546649 3.972789e-01 0.6261505531 3 180914652 180914995 344 + 0.409 0.561 0.750
ENSG00000114416 E013 0.0000000       3 180915434 180915459 26 +      
ENSG00000114416 E014 0.0000000       3 180915460 180915528 69 +      
ENSG00000114416 E015 0.0000000       3 180915529 180915631 103 +      
ENSG00000114416 E016 0.3040503 0.0274424043 6.536097e-01   3 180927648 180927813 166 + 0.144 0.000 -9.478
ENSG00000114416 E017 0.1614157 0.0334575076 1.000000e+00   3 180933036 180933333 298 + 0.078 0.000 -8.434
ENSG00000114416 E018 154.2755935 0.0002654165 4.326927e-01 0.6532763257 3 180933334 180933386 53 + 2.151 2.126 -0.085
ENSG00000114416 E019 220.0931803 0.0011763892 2.279770e-02 0.1053002363 3 180935138 180935231 94 + 2.318 2.246 -0.240
ENSG00000114416 E020 217.5850077 0.0039339074 2.608244e-01 0.4998249773 3 180947865 180947936 72 + 2.306 2.258 -0.160
ENSG00000114416 E021 0.6957271 0.0190273047 3.342421e-01   3 180947937 180948192 256 + 0.144 0.314 1.429
ENSG00000114416 E022 274.1320301 0.0002807656 4.631742e-02 0.1708351485 3 180948347 180948495 149 + 2.407 2.358 -0.164
ENSG00000114416 E023 230.6459727 0.0007099408 4.177795e-02 0.1593418910 3 180948721 180948814 94 + 2.334 2.275 -0.196
ENSG00000114416 E024 260.3447406 0.0010098405 3.717881e-01 0.6054735455 3 180949227 180949343 117 + 2.379 2.353 -0.084
ENSG00000114416 E025 177.6731085 0.0002919439 9.359922e-01 0.9702135630 3 180951298 180951329 32 + 2.206 2.203 -0.009
ENSG00000114416 E026 316.7361840 0.0001620187 3.490274e-01 0.5864191171 3 180951330 180951468 139 + 2.450 2.470 0.068
ENSG00000114416 E027 264.1082909 0.0002140924 8.136685e-01 0.9044590379 3 180953762 180953840 79 + 2.376 2.382 0.020
ENSG00000114416 E028 3.1303586 0.0071895312 1.079098e-02 0.0614951791 3 180953841 180954105 265 + 0.676 0.184 -2.822
ENSG00000114416 E029 5.2240223 0.0247334772 2.031694e-02 0.0969943794 3 180957527 180957808 282 + 0.829 0.413 -1.855
ENSG00000114416 E030 1.7631367 0.0111143188 4.928885e-01 0.6958858958 3 180957809 180957818 10 + 0.443 0.313 -0.744
ENSG00000114416 E031 227.1501797 0.0002723440 9.668164e-01 0.9853120617 3 180957819 180957868 50 + 2.311 2.313 0.005
ENSG00000114416 E032 250.3278717 0.0002520968 8.858886e-02 0.2611680477 3 180957869 180957928 60 + 2.341 2.383 0.142
ENSG00000114416 E033 264.4835568 0.0012562019 2.700544e-01 0.5100476589 3 180961468 180961554 87 + 2.367 2.398 0.101
ENSG00000114416 E034 243.1746100 0.0002757165 7.602174e-02 0.2368242937 3 180962883 180962940 58 + 2.326 2.371 0.148
ENSG00000114416 E035 72.1234417 0.0038137013 1.710642e-01 0.3919299398 3 180962941 180963027 87 + 1.834 1.757 -0.262
ENSG00000114416 E036 258.9162067 0.0009250792 1.394083e-02 0.0741016407 3 180963028 180963090 63 + 2.346 2.412 0.220
ENSG00000114416 E037 483.7685789 0.0001564328 2.988291e-01 0.5392957073 3 180968051 180968254 204 + 2.632 2.651 0.061
ENSG00000114416 E038 5.5214180 0.0053590646 3.254376e-02 0.1348233439 3 180968255 180968405 151 + 0.839 0.494 -1.480
ENSG00000114416 E039 230.3211753 0.0003055162 7.748167e-01 0.8816488931 3 180970158 180970191 34 + 2.317 2.309 -0.027
ENSG00000114416 E040 408.6797155 0.0001853311 7.981940e-01 0.8952887304 3 180970192 180970358 167 + 2.567 2.562 -0.017
ENSG00000114416 E041 42.5645482 0.0008472505 1.719272e-05 0.0003361021 3 180970359 180970661 303 + 1.654 1.366 -0.989
ENSG00000114416 E042 17.2030836 0.0174232403 6.251799e-01 0.7874449952 3 180971075 180971155 81 + 1.200 1.251 0.181
ENSG00000114416 E043 64.0184477 0.0007533227 1.221336e-02 0.0673018892 3 180971156 180971816 661 + 1.798 1.667 -0.442
ENSG00000114416 E044 104.7848429 0.0005950605 7.537733e-01 0.8689941067 3 180975313 180975404 92 + 1.985 1.973 -0.041
ENSG00000114416 E045 581.9708215 0.0003943356 3.970060e-03 0.0289832157 3 180976122 180982753 6632 + 2.704 2.755 0.169