ENSG00000114354

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000240851 ENSG00000114354 HEK293_OSMI2_6hA HEK293_TMG_6hB TFG protein_coding protein_coding 102.4356 87.9065 120.428 19.70925 2.890796 0.4540853 47.62205 45.94798 34.197742 11.319856 1.837134 -0.4259927 0.4681958 0.5151000 0.2849667 -0.23013333 4.922087e-05 4.575636e-06 FALSE TRUE
ENST00000476228 ENSG00000114354 HEK293_OSMI2_6hA HEK293_TMG_6hB TFG protein_coding protein_coding 102.4356 87.9065 120.428 19.70925 2.890796 0.4540853 17.09476 15.80477 35.260847 4.070746 1.966966 1.1572034 0.1709125 0.1875667 0.2924000 0.10483333 3.691824e-01 4.575636e-06 FALSE TRUE
ENST00000490574 ENSG00000114354 HEK293_OSMI2_6hA HEK293_TMG_6hB TFG protein_coding protein_coding 102.4356 87.9065 120.428 19.70925 2.890796 0.4540853 20.67699 13.67413 37.194079 3.343197 2.856352 1.4429570 0.1978625 0.1536333 0.3081333 0.15450000 4.575636e-06 4.575636e-06 FALSE TRUE
ENST00000674645 ENSG00000114354 HEK293_OSMI2_6hA HEK293_TMG_6hB TFG protein_coding protein_coding 102.4356 87.9065 120.428 19.70925 2.890796 0.4540853 10.44488 9.67033 3.522428 3.016089 1.053745 -1.4543961 0.0997875 0.1109333 0.0297000 -0.08123333 3.118897e-02 4.575636e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000114354 E001 0.0000000       3 100709295 100709316 22 +      
ENSG00000114354 E002 3.5964225 0.1323817304 3.307786e-01 5.697164e-01 3 100709317 100709352 36 + 0.745 0.566 -0.767
ENSG00000114354 E003 6.7128336 0.1613586586 2.314057e-01 4.667554e-01 3 100709353 100709361 9 + 0.983 0.737 -0.951
ENSG00000114354 E004 36.6269215 0.0010853982 5.513104e-04 6.142176e-03 3 100709362 100709413 52 + 1.653 1.465 -0.644
ENSG00000114354 E005 38.2183489 0.0010531997 1.434465e-04 2.021788e-03 3 100709414 100709428 15 + 1.676 1.470 -0.703
ENSG00000114354 E006 36.8037894 0.0010844254 1.252793e-04 1.803358e-03 3 100709429 100709431 3 + 1.662 1.449 -0.727
ENSG00000114354 E007 4.9684797 0.0062569093 2.404686e-01 4.771101e-01 3 100709432 100709439 8 + 0.849 0.708 -0.561
ENSG00000114354 E008 8.0432442 0.0085608562 6.719557e-01 8.175669e-01 3 100709440 100709456 17 + 0.978 0.947 -0.113
ENSG00000114354 E009 9.1191891 0.0253511461 7.073706e-01 8.401447e-01 3 100709457 100709461 5 + 0.979 1.047 0.249
ENSG00000114354 E010 8.5346214 0.0330606010 6.936113e-01 8.314297e-01 3 100709462 100709462 1 + 0.951 1.020 0.255
ENSG00000114354 E011 11.2848438 0.0083014633 7.826359e-01 8.861924e-01 3 100709463 100709471 9 + 1.076 1.123 0.170
ENSG00000114354 E012 26.4271352 0.0072771152 4.068808e-02 1.565209e-01 3 100709472 100709493 22 + 1.353 1.531 0.613
ENSG00000114354 E013 64.6986661 0.0038769395 2.075072e-08 9.068320e-07 3 100709494 100709535 42 + 1.642 1.960 1.074
ENSG00000114354 E014 66.7168958 0.0036562034 1.308234e-10 9.060693e-09 3 100709536 100709549 14 + 1.629 1.987 1.206
ENSG00000114354 E015 95.0983450 0.0116947496 7.823244e-10 4.656736e-08 3 100709550 100709588 39 + 1.738 2.155 1.400
ENSG00000114354 E016 107.6972514 0.0231626487 5.557912e-06 1.263874e-04 3 100709589 100709605 17 + 1.813 2.196 1.286
ENSG00000114354 E017 106.1580465 0.0323113960 3.978313e-05 6.845077e-04 3 100709606 100709612 7 + 1.800 2.192 1.317
ENSG00000114354 E018 253.9583012 0.0054435946 5.901733e-05 9.603775e-04 3 100709613 100709721 109 + 2.312 2.490 0.596
ENSG00000114354 E019 2.7377655 0.0088783030 3.798220e-01 6.120306e-01 3 100709722 100709821 100 + 0.495 0.646 0.692
ENSG00000114354 E020 3.1958074 0.0076672117 1.157564e-02 6.472014e-02 3 100709970 100710244 275 + 0.767 0.376 -1.819
ENSG00000114354 E021 2.4237023 0.0173029033 3.275264e-02 1.353672e-01 3 100710245 100710295 51 + 0.666 0.308 -1.815
ENSG00000114354 E022 1.9548557 0.0788838674 1.704920e-01 3.910933e-01 3 100710971 100711018 48 + 0.573 0.307 -1.415
ENSG00000114354 E023 3.2311566 0.0072399724 1.140161e-02 6.399998e-02 3 100711019 100711068 50 + 0.767 0.375 -1.819
ENSG00000114354 E024 186.9005272 0.0020690413 4.350795e-01 6.550396e-01 3 100713643 100713653 11 + 2.279 2.265 -0.046
ENSG00000114354 E025 864.4396870 0.0001001627 1.769447e-12 1.740978e-10 3 100713654 100713869 216 + 2.969 2.900 -0.230
ENSG00000114354 E026 738.5915051 0.0001446785 6.419354e-15 9.681651e-13 3 100719975 100720058 84 + 2.909 2.820 -0.296
ENSG00000114354 E027 960.2386906 0.0005486029 3.936182e-05 6.789784e-04 3 100728712 100728858 147 + 3.004 2.956 -0.161
ENSG00000114354 E028 3.9656997 0.0212948963 7.973461e-03 4.918562e-02 3 100728859 100729830 972 + 0.848 0.434 -1.818
ENSG00000114354 E029 0.5845677 0.3056646644 1.000000e+00   3 100731742 100731895 154 + 0.206 0.221 0.124
ENSG00000114354 E030 870.0977166 0.0001938084 1.582295e-01 3.741076e-01 3 100732508 100732672 165 + 2.941 2.939 -0.007
ENSG00000114354 E031 43.9372523 0.0402179048 4.636953e-06 1.078131e-04 3 100732673 100736575 3903 + 1.830 1.296 -1.827
ENSG00000114354 E032 678.2743280 0.0001867223 1.367161e-01 3.424816e-01 3 100736576 100736704 129 + 2.816 2.854 0.128
ENSG00000114354 E033 227.2013639 0.0014268380 4.671111e-01 6.781177e-01 3 100736705 100736716 12 + 2.340 2.382 0.138
ENSG00000114354 E034 5.3755295 0.0050415769 1.298539e-06 3.564276e-05 3 100739361 100739485 125 + 1.017 0.307 -3.189
ENSG00000114354 E035 5.5618291 0.0076742914 1.559309e-07 5.521403e-06 3 100742156 100742200 45 + 1.030 0.227 -3.823
ENSG00000114354 E036 60.0254833 0.0312979584 2.278518e-07 7.726533e-06 3 100742476 100744832 2357 + 1.962 1.429 -1.808
ENSG00000114354 E037 297.5212205 0.0002251671 4.240460e-01 6.465584e-01 3 100744833 100744837 5 + 2.461 2.496 0.117
ENSG00000114354 E038 514.0806280 0.0003466387 2.030863e-06 5.292116e-05 3 100744838 100744931 94 + 2.664 2.764 0.332
ENSG00000114354 E039 43.5576447 0.0029190590 1.130709e-22 4.455229e-20 3 100744932 100747245 2314 + 1.843 1.207 -2.183
ENSG00000114354 E040 3.6994487 0.0640595594 1.654772e-01 3.845248e-01 3 100747246 100747308 63 + 0.771 0.529 -1.044
ENSG00000114354 E041 2.3949536 0.5200709889 9.147690e-02 2.664234e-01 3 100747309 100747360 52 + 0.716 0.125 -3.657
ENSG00000114354 E042 2.5507598 0.3968477446 1.473424e-01 3.585090e-01 3 100747361 100747413 53 + 0.712 0.225 -2.617
ENSG00000114354 E043 3.4077851 0.0104323624 2.748970e-02 1.197666e-01 3 100747414 100747454 41 + 0.768 0.434 -1.502
ENSG00000114354 E044 262.0507590 0.0003132043 1.250202e-03 1.179255e-02 3 100748149 100748152 4 + 2.378 2.469 0.304
ENSG00000114354 E045 2212.1572613 0.0017738498 1.174886e-01 3.116231e-01 3 100748153 100748964 812 + 3.324 3.366 0.139