ENSG00000114127

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392981 ENSG00000114127 HEK293_OSMI2_6hA HEK293_TMG_6hB XRN1 protein_coding protein_coding 4.411724 0.8355378 10.93922 0.1038327 0.64758 3.694815 2.4326386 0.7744216 5.114488 0.1102793 0.2028426 2.707707 0.69449167 0.9226 0.4723667 -0.4502333 8.660667e-05 8.660667e-05 FALSE TRUE
ENST00000472625 ENSG00000114127 HEK293_OSMI2_6hA HEK293_TMG_6hB XRN1 protein_coding retained_intron 4.411724 0.8355378 10.93922 0.1038327 0.64758 3.694815 0.6640377 0.0000000 2.542447 0.0000000 0.7212865 7.995737 0.07885417 0.0000 0.2260000 0.2260000 3.097879e-03 8.660667e-05 FALSE FALSE
MSTRG.23842.5 ENSG00000114127 HEK293_OSMI2_6hA HEK293_TMG_6hB XRN1 protein_coding   4.411724 0.8355378 10.93922 0.1038327 0.64758 3.694815 0.5037085 0.0000000 1.193711 0.0000000 0.2741641 6.911345 0.06444167 0.0000 0.1129667 0.1129667 3.785052e-02 8.660667e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000114127 E001 0.0000000       3 142306607 142306609 3 -      
ENSG00000114127 E002 234.0275349 0.0004123283 3.432939e-19 8.955330e-17 3 142306610 142309391 2782 - 2.147 2.404 0.860
ENSG00000114127 E003 122.6717062 0.0005008208 8.184135e-02 2.484678e-01 3 142309392 142311014 1623 - 1.902 1.980 0.262
ENSG00000114127 E004 43.5780022 0.0013470359 8.241854e-01 9.103882e-01 3 142311015 142311519 505 - 1.470 1.488 0.059
ENSG00000114127 E005 40.2394061 0.0010894208 3.767568e-01 6.096623e-01 3 142311520 142311813 294 - 1.430 1.500 0.239
ENSG00000114127 E006 38.7454630 0.0010203034 7.198695e-01 8.481210e-01 3 142312598 142312758 161 - 1.419 1.449 0.103
ENSG00000114127 E007 2.9455274 0.0126740387 9.084735e-01 9.563879e-01 3 142313136 142313174 39 - 0.464 0.439 -0.126
ENSG00000114127 E008 28.0188776 0.0034086506 2.525618e-01 4.906492e-01 3 142318592 142318646 55 - 1.298 1.176 -0.430
ENSG00000114127 E009 27.1841296 0.0136839046 5.205053e-01 7.152622e-01 3 142318647 142318694 48 - 1.281 1.200 -0.283
ENSG00000114127 E010 28.4442264 0.0084441829 6.369757e-01 7.950395e-01 3 142318790 142318903 114 - 1.298 1.245 -0.186
ENSG00000114127 E011 23.1075971 0.0018128430 1.026718e-01 2.865413e-01 3 142329434 142329483 50 - 1.184 1.342 0.555
ENSG00000114127 E012 31.7340107 0.0011172958 3.600961e-01 5.957796e-01 3 142329484 142329615 132 - 1.327 1.406 0.276
ENSG00000114127 E013 21.6479979 0.0035298496 9.959537e-01 9.995868e-01 3 142332375 142332424 50 - 1.178 1.176 -0.006
ENSG00000114127 E014 24.8699489 0.0014722860 2.912347e-01 5.318046e-01 3 142332425 142332531 107 - 1.223 1.325 0.357
ENSG00000114127 E015 10.4961267 0.0032908851 2.719207e-01 5.117797e-01 3 142332532 142332534 3 - 0.878 1.026 0.555
ENSG00000114127 E016 0.4161375 0.1251258166 3.097124e-01   3 142332865 142332966 102 - 0.092 0.271 1.878
ENSG00000114127 E017 27.6542332 0.0015994146 6.321178e-01 7.917563e-01 3 142332967 142333089 123 - 1.278 1.324 0.161
ENSG00000114127 E018 17.9938092 0.0051781964 9.019955e-01 9.529057e-01 3 142335448 142335509 62 - 1.107 1.092 -0.055
ENSG00000114127 E019 28.9964147 0.0011840085 6.248798e-01 7.872630e-01 3 142347234 142347342 109 - 1.297 1.342 0.158
ENSG00000114127 E020 0.0000000       3 142355324 142355400 77 -      
ENSG00000114127 E021 32.3944876 0.0029825108 6.522446e-01 8.048830e-01 3 142355401 142355496 96 - 1.349 1.306 -0.151
ENSG00000114127 E022 29.6144256 0.0040542205 4.971638e-01 6.990205e-01 3 142356912 142356982 71 - 1.315 1.246 -0.245
ENSG00000114127 E023 30.7098853 0.0013302759 1.594938e-01 3.760130e-01 3 142356983 142357119 137 - 1.341 1.200 -0.495
ENSG00000114127 E024 20.3130499 0.0126066548 5.243345e-01 7.180240e-01 3 142359862 142359931 70 - 1.151 1.223 0.257
ENSG00000114127 E025 30.9399048 0.0065234188 8.931937e-01 9.482732e-01 3 142365047 142365179 133 - 1.331 1.342 0.038
ENSG00000114127 E026 25.6513994 0.0016549637 7.602774e-01 8.727011e-01 3 142365310 142365366 57 - 1.256 1.224 -0.112
ENSG00000114127 E027 36.7526587 0.0226632990 7.437831e-01 8.628597e-01 3 142370485 142370620 136 - 1.407 1.371 -0.124
ENSG00000114127 E028 28.9273804 0.0093156882 2.134966e-01 4.458035e-01 3 142371239 142371328 90 - 1.317 1.175 -0.499
ENSG00000114127 E029 32.3809167 0.0021533291 1.649239e-01 3.838946e-01 3 142375798 142375944 147 - 1.362 1.224 -0.483
ENSG00000114127 E030 1.5887372 0.0112855147 2.402409e-01 4.768400e-01 3 142375945 142375991 47 - 0.340 0.000 -11.049
ENSG00000114127 E031 2.2204205 0.0092312107 5.598521e-01 7.431715e-01 3 142376249 142376478 230 - 0.406 0.273 -0.824
ENSG00000114127 E032 22.7770595 0.0017728415 5.828166e-01 7.588832e-01 3 142376479 142376594 116 - 1.210 1.150 -0.215
ENSG00000114127 E033 25.3385584 0.0014857017 4.311077e-01 6.520091e-01 3 142380082 142380180 99 - 1.258 1.176 -0.293
ENSG00000114127 E034 26.7310087 0.0033063913 9.752580e-01 9.894814e-01 3 142383300 142383413 114 - 1.270 1.267 -0.010
ENSG00000114127 E035 31.8533372 0.0064716956 7.622160e-01 8.739690e-01 3 142384523 142384685 163 - 1.340 1.307 -0.114
ENSG00000114127 E036 29.7803187 0.0121790024 1.527922e-01 3.663553e-01 3 142397329 142397460 132 - 1.325 1.152 -0.612
ENSG00000114127 E037 26.3283521 0.0012955184 4.987658e-01 6.999463e-01 3 142400444 142400547 104 - 1.270 1.200 -0.245
ENSG00000114127 E038 23.1854210 0.0036956970 3.981052e-01 6.268111e-01 3 142403674 142403772 99 - 1.217 1.122 -0.341
ENSG00000114127 E039 26.5261303 0.0023144001 1.786301e-03 1.560698e-02 3 142403869 142403989 121 - 1.295 0.903 -1.420
ENSG00000114127 E040 29.2320863 0.0012031323 5.695536e-02 1.959350e-01 3 142404907 142405073 167 - 1.325 1.122 -0.716
ENSG00000114127 E041 12.4095669 0.0025440741 1.122192e-01 3.028156e-01 3 142405074 142405076 3 - 0.981 0.730 -0.970
ENSG00000114127 E042 13.3868068 0.0024457376 1.594101e-01 3.758608e-01 3 142412544 142412547 4 - 1.007 0.796 -0.804
ENSG00000114127 E043 26.3411429 0.0210508109 3.737031e-01 6.071133e-01 3 142412548 142412663 116 - 1.273 1.152 -0.429
ENSG00000114127 E044 30.5545293 0.0013677708 9.494059e-01 9.767778e-01 3 142414135 142414291 157 - 1.320 1.325 0.018
ENSG00000114127 E045 0.0000000       3 142414292 142414340 49 -      
ENSG00000114127 E046 21.5837523 0.0017311941 6.616394e-01 8.108856e-01 3 142417140 142417229 90 - 1.177 1.224 0.164
ENSG00000114127 E047 3.5056549 0.0073590688 6.718568e-01 8.174817e-01 3 142417841 142418418 578 - 0.529 0.439 -0.443
ENSG00000114127 E048 1.0988806 0.1545016380 8.129722e-01   3 142418419 142418503 85 - 0.233 0.274 0.310
ENSG00000114127 E049 28.9947563 0.0015146172 8.607528e-01 9.307534e-01 3 142418504 142418609 106 - 1.304 1.287 -0.060
ENSG00000114127 E050 20.7059960 0.0018021598 6.351041e-02 2.106137e-01 3 142418815 142418881 67 - 1.184 0.948 -0.858
ENSG00000114127 E051 26.1882965 0.0111784525 8.176724e-02 2.483316e-01 3 142421016 142421153 138 - 1.280 1.061 -0.781
ENSG00000114127 E052 18.5081663 0.0103608758 9.069765e-02 2.650585e-01 3 142421476 142421543 68 - 1.142 0.903 -0.878
ENSG00000114127 E053 18.1712854 0.0028393994 1.717967e-01 3.929348e-01 3 142422582 142422634 53 - 1.127 0.948 -0.653
ENSG00000114127 E054 21.6855687 0.0016950126 3.754841e-01 6.085747e-01 3 142422635 142422750 116 - 1.194 1.092 -0.364
ENSG00000114127 E055 20.2180582 0.0019106702 1.423020e-01 3.508697e-01 3 142422835 142422922 88 - 1.171 0.989 -0.660
ENSG00000114127 E056 23.3018505 0.0015664382 8.588348e-03 5.199084e-02 3 142423560 142423642 83 - 1.238 0.903 -1.221
ENSG00000114127 E057 24.7877279 0.0021435916 4.396961e-03 3.136230e-02 3 142425222 142425332 111 - 1.265 0.903 -1.313
ENSG00000114127 E058 22.9823474 0.0017862221 9.269707e-03 5.497693e-02 3 142425429 142425538 110 - 1.235 0.903 -1.211
ENSG00000114127 E059 0.1614157 0.0323814641 7.509148e-01   3 142426564 142426743 180 - 0.049 0.000 -7.774
ENSG00000114127 E060 21.6382814 0.0016192855 5.367641e-01 7.268782e-01 3 142426744 142426841 98 - 1.191 1.122 -0.246
ENSG00000114127 E061 0.0000000       3 142429695 142429774 80 -      
ENSG00000114127 E062 31.8476950 0.0014492529 1.858700e-01 4.116661e-01 3 142432661 142432893 233 - 1.353 1.224 -0.454
ENSG00000114127 E063 0.3150090 0.0274626121 1.472895e-01   3 142435013 142435390 378 - 0.049 0.273 2.880
ENSG00000114127 E064 0.1426347 0.0318841584 7.501248e-01   3 142435951 142436056 106 - 0.049 0.000 -7.776
ENSG00000114127 E065 17.2581891 0.0023891118 2.120734e-01 4.441892e-01 3 142447870 142448062 193 - 1.111 0.948 -0.597