ENSG00000114126

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000467072 ENSG00000114126 HEK293_OSMI2_6hA HEK293_TMG_6hB TFDP2 protein_coding protein_coding 17.2795 7.653359 25.68181 0.5671033 1.578937 1.74526 1.0008239 0.3235147 1.0844769 0.19946825 0.23543007 1.7144194 0.05230833 0.04300000 0.04373333 0.0007333333 9.334969e-01 1.966804e-18 FALSE TRUE
ENST00000479040 ENSG00000114126 HEK293_OSMI2_6hA HEK293_TMG_6hB TFDP2 protein_coding protein_coding 17.2795 7.653359 25.68181 0.5671033 1.578937 1.74526 4.3228336 0.0000000 8.2320667 0.00000000 1.33642747 9.6868623 0.21210417 0.00000000 0.31636667 0.3163666667 1.966804e-18 1.966804e-18 FALSE TRUE
ENST00000486111 ENSG00000114126 HEK293_OSMI2_6hA HEK293_TMG_6hB TFDP2 protein_coding protein_coding 17.2795 7.653359 25.68181 0.5671033 1.578937 1.74526 2.2965635 0.4205274 5.1286904 0.21243422 0.57368280 3.5772238 0.09942083 0.05133333 0.19963333 0.1483000000 3.782743e-01 1.966804e-18 FALSE TRUE
ENST00000489671 ENSG00000114126 HEK293_OSMI2_6hA HEK293_TMG_6hB TFDP2 protein_coding protein_coding 17.2795 7.653359 25.68181 0.5671033 1.578937 1.74526 4.3836281 3.8537909 5.7682470 0.03592141 0.06549094 0.5806148 0.27718333 0.50980000 0.22673333 -0.2830666667 2.683064e-04 1.966804e-18 FALSE TRUE
ENST00000499676 ENSG00000114126 HEK293_OSMI2_6hA HEK293_TMG_6hB TFDP2 protein_coding protein_coding 17.2795 7.653359 25.68181 0.5671033 1.578937 1.74526 1.1622373 1.7249633 0.2185637 0.43344372 0.21856375 -2.9242366 0.12741250 0.22116667 0.00790000 -0.2132666667 1.648546e-02 1.966804e-18 FALSE TRUE
MSTRG.23837.12 ENSG00000114126 HEK293_OSMI2_6hA HEK293_TMG_6hB TFDP2 protein_coding   17.2795 7.653359 25.68181 0.5671033 1.578937 1.74526 0.9752007 0.6292175 0.9252203 0.62921750 0.46708734 0.5489993 0.05828750 0.07490000 0.03696667 -0.0379333333 8.523396e-01 1.966804e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000114126 E001 0.3032425 0.0274424043 9.547635e-02   3 141944428 141944434 7 - 0.000 0.281 10.262
ENSG00000114126 E002 88.9069141 0.0019856795 1.595195e-21 5.597125e-19 3 141944435 141944888 454 - 1.699 2.180 1.618
ENSG00000114126 E003 62.3616521 0.0006997161 4.359145e-13 4.791476e-11 3 141944889 141945038 150 - 1.596 1.999 1.361
ENSG00000114126 E004 969.1823120 0.0024326622 1.331672e-47 3.707353e-44 3 141945039 141951501 6463 - 2.803 3.166 1.207
ENSG00000114126 E005 150.2198783 0.0008614840 9.999458e-01 1.000000e+00 3 141951502 141952142 641 - 2.128 2.204 0.253
ENSG00000114126 E006 80.1531575 0.0005920849 2.257885e-01 4.602798e-01 3 141952143 141952275 133 - 1.878 1.904 0.086
ENSG00000114126 E007 78.4919815 0.0004593120 3.820074e-02 1.501253e-01 3 141952276 141952473 198 - 1.881 1.871 -0.035
ENSG00000114126 E008 19.6573723 0.0041881552 2.117819e-01 4.438424e-01 3 141952474 141952480 7 - 1.231 1.407 0.614
ENSG00000114126 E009 22.5011357 0.0018534132 1.827232e-01 4.075787e-01 3 141952481 141952495 15 - 1.286 1.458 0.599
ENSG00000114126 E010 132.1532271 0.0016640986 4.313690e-02 1.629114e-01 3 141952496 141952696 201 - 2.102 2.106 0.011
ENSG00000114126 E011 2.0832371 0.0140838555 3.891600e-01 6.198318e-01 3 141952829 141952910 82 - 0.376 0.573 0.994
ENSG00000114126 E012 127.8333451 0.0004605141 1.119038e-07 4.100958e-06 3 141952911 141953016 106 - 2.120 2.016 -0.349
ENSG00000114126 E013 136.7405301 0.0004331744 2.550988e-08 1.093153e-06 3 141959674 141959799 126 - 2.149 2.042 -0.359
ENSG00000114126 E014 74.8765490 0.0005608755 1.119944e-05 2.313775e-04 3 141959800 141959840 41 - 1.891 1.773 -0.401
ENSG00000114126 E015 59.6699403 0.0006968054 4.942922e-04 5.622760e-03 3 141963812 141963819 8 - 1.788 1.692 -0.325
ENSG00000114126 E016 69.9869954 0.0005738950 4.453148e-04 5.178355e-03 3 141963820 141963851 32 - 1.853 1.769 -0.281
ENSG00000114126 E017 98.2299985 0.0008210759 3.302871e-04 4.040218e-03 3 141963852 141963963 112 - 1.995 1.930 -0.218
ENSG00000114126 E018 70.5725575 0.0007175418 1.507523e-04 2.107442e-03 3 141970073 141970141 69 - 1.865 1.769 -0.324
ENSG00000114126 E019 52.2821694 0.0007451523 6.692790e-03 4.315726e-02 3 141974048 141974066 19 - 1.727 1.663 -0.219
ENSG00000114126 E020 64.2724088 0.0011816227 1.625896e-03 1.450334e-02 3 141974067 141974104 38 - 1.821 1.745 -0.257
ENSG00000114126 E021 86.5898062 0.0056483618 3.627649e-04 4.365492e-03 3 141974105 141974191 87 - 1.959 1.845 -0.383
ENSG00000114126 E022 17.0233778 0.0072590119 1.091013e-01 2.975989e-01 3 141974192 141974194 3 - 1.265 1.190 -0.264
ENSG00000114126 E023 55.1985769 0.0010736891 1.565373e-05 3.094719e-04 3 141978520 141978536 17 - 1.777 1.627 -0.508
ENSG00000114126 E024 74.0881180 0.0005111616 3.564719e-08 1.473281e-06 3 141978537 141978587 51 - 1.905 1.734 -0.577
ENSG00000114126 E025 103.7416802 0.0004971220 1.392245e-13 1.682813e-11 3 141978588 141978682 95 - 2.060 1.849 -0.708
ENSG00000114126 E026 0.0000000       3 141978683 141978688 6 -      
ENSG00000114126 E027 0.1426347 0.0317439339 7.831120e-01   3 141989067 141989514 448 - 0.089 0.000 -11.122
ENSG00000114126 E028 66.9662689 0.0005847442 8.066224e-10 4.796325e-08 3 141993538 141993572 35 - 1.873 1.654 -0.740
ENSG00000114126 E029 65.1980898 0.0005896872 1.945166e-10 1.295427e-08 3 141993573 141993585 13 - 1.866 1.632 -0.794
ENSG00000114126 E030 0.3393995 0.0274424043 3.796152e-01   3 141994270 141995019 750 - 0.164 0.000 -12.181
ENSG00000114126 E031 70.7040127 0.0006604870 5.968309e-06 1.342814e-04 3 141995020 141995062 43 - 1.876 1.745 -0.441
ENSG00000114126 E032 51.8132153 0.0008801425 4.703176e-04 5.406170e-03 3 141995063 141995070 8 - 1.737 1.627 -0.371
ENSG00000114126 E033 63.9214476 0.0007907796 1.618043e-04 2.239636e-03 3 141995071 141995095 25 - 1.824 1.719 -0.354
ENSG00000114126 E034 78.6220318 0.0004917725 1.981609e-08 8.695680e-07 3 141995096 141995141 46 - 1.928 1.759 -0.570
ENSG00000114126 E035 0.4702677 0.0217681645 8.970766e-01   3 141995142 141995229 88 - 0.164 0.163 -0.012
ENSG00000114126 E036 1.8613620 0.0614428603 5.163678e-01 7.125354e-01 3 142000252 142000324 73 - 0.454 0.374 -0.433
ENSG00000114126 E037 1.5385306 0.2451419225 9.661238e-01 9.849679e-01 3 142000325 142000354 30 - 0.382 0.375 -0.036
ENSG00000114126 E038 100.9927466 0.0004878862 7.216848e-11 5.255518e-09 3 142005441 142005544 104 - 2.036 1.857 -0.600
ENSG00000114126 E039 10.8794995 0.0046859405 3.909614e-03 2.864323e-02 3 142028579 142028665 87 - 1.126 0.867 -0.955
ENSG00000114126 E040 0.0000000       3 142029042 142029157 116 -      
ENSG00000114126 E041 4.9074500 0.0752820176 1.328539e-01 3.362993e-01 3 142054115 142054149 35 - 0.801 0.578 -0.934
ENSG00000114126 E042 0.0000000       3 142090792 142090838 47 -      
ENSG00000114126 E043 0.7035494 0.0343244683 6.086505e-01   3 142093031 142093060 30 - 0.227 0.163 -0.592
ENSG00000114126 E044 62.6481645 0.0009946797 6.056229e-04 6.627276e-03 3 142093061 142093127 67 - 1.807 1.716 -0.310
ENSG00000114126 E045 50.2389800 0.0032948577 1.098253e-02 6.229411e-02 3 142101735 142101774 40 - 1.713 1.640 -0.246
ENSG00000114126 E046 37.4024424 0.0011358373 2.094112e-01 4.411913e-01 3 142101775 142101841 67 - 1.567 1.567 0.000
ENSG00000114126 E047 0.0000000       3 142126149 142126370 222 -      
ENSG00000114126 E048 34.9171183 0.0129664364 4.773929e-01 6.853036e-01 3 142149183 142149544 362 - 1.487 1.622 0.462