ENSG00000114098

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000461822 ENSG00000114098 HEK293_OSMI2_6hA HEK293_TMG_6hB ARMC8 protein_coding protein_coding 13.09634 5.034999 19.72082 0.9229817 1.13493 1.967525 0.7769759 0.04227586 1.1122943 0.04227586 0.4534272 4.4241624 0.05022083 0.006766667 0.05870000 0.051933333 3.894624e-01 2.744522e-06 FALSE TRUE
ENST00000469044 ENSG00000114098 HEK293_OSMI2_6hA HEK293_TMG_6hB ARMC8 protein_coding protein_coding 13.09634 5.034999 19.72082 0.9229817 1.13493 1.967525 0.8304781 1.11232991 1.0020363 0.16334337 1.0020363 -0.1492358 0.11170833 0.229900000 0.04710000 -0.182800000 1.891010e-01 2.744522e-06 FALSE TRUE
ENST00000470842 ENSG00000114098 HEK293_OSMI2_6hA HEK293_TMG_6hB ARMC8 protein_coding retained_intron 13.09634 5.034999 19.72082 0.9229817 1.13493 1.967525 0.7157028 0.22318838 0.8605639 0.11170984 0.2652380 1.9004542 0.06383750 0.054833333 0.04560000 -0.009233333 9.914479e-01 2.744522e-06 FALSE FALSE
ENST00000471453 ENSG00000114098 HEK293_OSMI2_6hA HEK293_TMG_6hB ARMC8 protein_coding protein_coding 13.09634 5.034999 19.72082 0.9229817 1.13493 1.967525 0.7733198 0.13809893 1.2317407 0.13809893 0.6159006 3.0677309 0.06393750 0.042833333 0.05916667 0.016333333 8.033241e-01 2.744522e-06 FALSE TRUE
ENST00000481646 ENSG00000114098 HEK293_OSMI2_6hA HEK293_TMG_6hB ARMC8 protein_coding protein_coding 13.09634 5.034999 19.72082 0.9229817 1.13493 1.967525 0.6151060 0.62478608 0.0000000 0.31475086 0.0000000 -5.9881986 0.06300833 0.105833333 0.00000000 -0.105833333 9.606598e-02 2.744522e-06 FALSE TRUE
ENST00000485396 ENSG00000114098 HEK293_OSMI2_6hA HEK293_TMG_6hB ARMC8 protein_coding protein_coding 13.09634 5.034999 19.72082 0.9229817 1.13493 1.967525 1.4063850 0.45235375 2.6157695 0.23256479 0.5891836 2.5056713 0.08751250 0.075800000 0.13196667 0.056166667 7.670615e-01 2.744522e-06 FALSE TRUE
ENST00000491704 ENSG00000114098 HEK293_OSMI2_6hA HEK293_TMG_6hB ARMC8 protein_coding protein_coding 13.09634 5.034999 19.72082 0.9229817 1.13493 1.967525 1.0987485 0.23997878 1.8647033 0.11999761 0.2504969 2.9067847 0.07727500 0.056300000 0.09620000 0.039900000 7.567381e-01 2.744522e-06 FALSE TRUE
MSTRG.23781.2 ENSG00000114098 HEK293_OSMI2_6hA HEK293_TMG_6hB ARMC8 protein_coding   13.09634 5.034999 19.72082 0.9229817 1.13493 1.967525 1.1536054 0.00000000 2.8389327 0.00000000 0.8872509 8.1542777 0.05764167 0.000000000 0.14240000 0.142400000 2.744522e-06 2.744522e-06 TRUE TRUE
MSTRG.23781.4 ENSG00000114098 HEK293_OSMI2_6hA HEK293_TMG_6hB ARMC8 protein_coding   13.09634 5.034999 19.72082 0.9229817 1.13493 1.967525 1.8387665 0.74518316 2.3704244 0.42452108 1.3403530 1.6563203 0.11815417 0.157533333 0.12296667 -0.034566667 9.905958e-01 2.744522e-06 TRUE TRUE
MSTRG.23781.8 ENSG00000114098 HEK293_OSMI2_6hA HEK293_TMG_6hB ARMC8 protein_coding   13.09634 5.034999 19.72082 0.9229817 1.13493 1.967525 0.7482710 0.21400352 1.2625555 0.12469660 0.1896551 2.5061353 0.06567083 0.047300000 0.06503333 0.017733333 8.517601e-01 2.744522e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000114098 E001 0.0000000       3 138187248 138187266 19 +      
ENSG00000114098 E002 0.9770522 0.0156111225 7.011179e-01   3 138187267 138187300 34 + 0.246 0.320 0.513
ENSG00000114098 E003 1.4830290 0.0122237161 6.654135e-02 0.2172764584 3 138187301 138187304 4 + 0.246 0.571 1.836
ENSG00000114098 E004 1.6138971 0.0113822615 2.717610e-02 0.1188210304 3 138187305 138187308 4 + 0.246 0.630 2.098
ENSG00000114098 E005 4.6858509 0.0056369563 3.297667e-01 0.5687197905 3 138187309 138187317 9 + 0.665 0.810 0.588
ENSG00000114098 E006 7.0136066 0.0046247292 4.199907e-01 0.6436378075 3 138187318 138187341 24 + 0.828 0.936 0.412
ENSG00000114098 E007 8.4492302 0.0094719596 2.910446e-01 0.5316205068 3 138187342 138187349 8 + 0.896 1.032 0.506
ENSG00000114098 E008 9.9451410 0.0375083391 3.210972e-01 0.5606397189 3 138187350 138187354 5 + 0.955 1.105 0.551
ENSG00000114098 E009 18.4760984 0.0494497939 3.416160e-01 0.5794352500 3 138187355 138187468 114 + 1.201 1.352 0.529
ENSG00000114098 E010 16.5126963 0.0256988944 2.529102e-01 0.4911374853 3 138187469 138187516 48 + 1.158 1.305 0.520
ENSG00000114098 E011 9.6870549 0.0040935982 4.413827e-01 0.6596628163 3 138187517 138187527 11 + 0.964 1.055 0.334
ENSG00000114098 E012 9.3476554 0.0068767635 3.625937e-01 0.5978158032 3 138187528 138187528 1 + 0.945 1.054 0.403
ENSG00000114098 E013 9.7176024 0.0036827548 6.158612e-01 0.7808992888 3 138187529 138187530 2 + 0.973 1.034 0.224
ENSG00000114098 E014 17.6897062 0.0020872315 2.559535e-01 0.4947031326 3 138187531 138187546 16 + 1.250 1.148 -0.362
ENSG00000114098 E015 28.3248367 0.0022644932 2.867749e-01 0.5274885508 3 138187547 138187551 5 + 1.443 1.367 -0.260
ENSG00000114098 E016 47.6507091 0.0150403675 2.901519e-01 0.5307632128 3 138187552 138187599 48 + 1.659 1.585 -0.253
ENSG00000114098 E017 0.8866948 0.0173594132 1.290556e-02   3 138187776 138188400 625 + 0.076 0.503 3.515
ENSG00000114098 E018 1.0573043 0.3658751455 7.589718e-01   3 138188401 138188454 54 + 0.297 0.193 -0.810
ENSG00000114098 E019 23.9617463 0.0018075034 8.929577e-04 0.0090383094 3 138188455 138188530 76 + 1.406 1.114 -1.028
ENSG00000114098 E020 43.3646827 0.0010392896 2.391500e-02 0.1088299744 3 138209817 138209893 77 + 1.629 1.491 -0.473
ENSG00000114098 E021 61.5605515 0.0006199988 1.453183e-02 0.0763682406 3 138221926 138221997 72 + 1.774 1.649 -0.422
ENSG00000114098 E022 75.3949787 0.0007090918 1.166444e-01 0.3102364790 3 138223389 138223531 143 + 1.850 1.781 -0.234
ENSG00000114098 E023 69.4305091 0.0005261440 6.597694e-02 0.2160902396 3 138223636 138223733 98 + 1.816 1.731 -0.288
ENSG00000114098 E024 63.6501836 0.0006018451 1.370211e-01 0.3429844271 3 138228918 138229010 93 + 1.775 1.704 -0.241
ENSG00000114098 E025 1.4158447 0.0761004359 4.972589e-01 0.6990910332 3 138229011 138229051 41 + 0.292 0.424 0.787
ENSG00000114098 E026 66.4162029 0.0008915140 1.887240e-01 0.4154095631 3 138235034 138235114 81 + 1.793 1.731 -0.208
ENSG00000114098 E027 1.0075998 0.0182222826 5.954307e-01   3 138237279 138237308 30 + 0.291 0.189 -0.807
ENSG00000114098 E028 62.5675484 0.0022267157 9.335962e-02 0.2699972366 3 138237309 138237384 76 + 1.772 1.685 -0.297
ENSG00000114098 E029 3.9706754 0.0067804035 2.768928e-01 0.5169097533 3 138237385 138237481 97 + 0.683 0.503 -0.808
ENSG00000114098 E030 70.3259733 0.0008287928 1.057423e-01 0.2918987970 3 138237482 138237572 91 + 1.819 1.744 -0.252
ENSG00000114098 E031 1.7567194 0.0112794575 1.751527e-01 0.3973782276 3 138238020 138239467 1448 + 0.331 0.571 1.251
ENSG00000114098 E032 59.7719461 0.0040079990 5.350407e-01 0.7256176512 3 138239468 138239528 61 + 1.737 1.704 -0.114
ENSG00000114098 E033 100.1926984 0.0037542009 4.103906e-01 0.6363564182 3 138241783 138241983 201 + 1.960 1.925 -0.118
ENSG00000114098 E034 73.6421185 0.0005996651 1.317155e-01 0.3345091715 3 138245088 138245183 96 + 1.836 1.769 -0.226
ENSG00000114098 E035 50.4406272 0.0007387819 1.669320e-03 0.0148090120 3 138245184 138246887 1704 + 1.608 1.777 0.575
ENSG00000114098 E036 1.9326780 0.0265596686 5.859120e-01 0.7609035280 3 138263511 138263738 228 + 0.403 0.503 0.514
ENSG00000114098 E037 53.0417179 0.0006850998 3.787422e-01 0.6112185196 3 138263739 138263821 83 + 1.693 1.649 -0.148
ENSG00000114098 E038 0.8206259 0.0234056275 5.090321e-01   3 138263822 138264130 309 + 0.197 0.320 0.925
ENSG00000114098 E039 42.7080675 0.0011248341 1.523432e-01 0.3657505361 3 138264131 138264212 82 + 1.606 1.521 -0.291
ENSG00000114098 E040 55.3815020 0.0127395300 1.108352e-01 0.3003482356 3 138267155 138267241 87 + 1.724 1.603 -0.411
ENSG00000114098 E041 63.8901385 0.0008365175 5.138703e-02 0.1830341012 3 138270040 138270132 93 + 1.781 1.685 -0.325
ENSG00000114098 E042 65.8146795 0.0007490339 2.670135e-02 0.1173677691 3 138272967 138273079 113 + 1.802 1.694 -0.364
ENSG00000114098 E043 41.7418248 0.0087449455 3.898622e-01 0.6203508617 3 138273080 138273116 37 + 1.599 1.533 -0.226
ENSG00000114098 E044 51.0547171 0.0022000344 6.976313e-01 0.8339911013 3 138274449 138274544 96 + 1.673 1.654 -0.065
ENSG00000114098 E045 55.9229684 0.0008735307 3.033444e-01 0.5439015430 3 138284431 138284526 96 + 1.686 1.744 0.197
ENSG00000114098 E046 4.8364284 0.1041406249 1.182230e-01 0.3129254522 3 138287632 138288014 383 + 0.609 0.951 1.369
ENSG00000114098 E047 0.4576437 0.2397755969 7.264806e-01   3 138289021 138289047 27 + 0.139 0.190 0.544
ENSG00000114098 E048 54.9953604 0.0007610394 1.769957e-01 0.3997490860 3 138289048 138289120 73 + 1.674 1.749 0.252
ENSG00000114098 E049 69.6837249 0.0005527701 3.728104e-03 0.0276253541 3 138290546 138290639 94 + 1.755 1.891 0.458
ENSG00000114098 E050 92.7889879 0.0004211108 5.048862e-05 0.0008387917 3 138295859 138296068 210 + 1.871 2.033 0.543
ENSG00000114098 E051 67.4847556 0.0007080153 2.694994e-03 0.0215435881 3 138296069 138296197 129 + 1.739 1.882 0.482
ENSG00000114098 E052 204.2633184 0.0029456388 2.186856e-04 0.0028792028 3 138296198 138298384 2187 + 2.219 2.350 0.437
ENSG00000114098 E053 0.7119354 1.0964077590 7.992775e-01   3 138298414 138298479 66 + 0.259 0.000 -9.558