ENSG00000113851

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000231948 ENSG00000113851 HEK293_OSMI2_6hA HEK293_TMG_6hB CRBN protein_coding protein_coding 23.42013 4.271204 45.49394 0.2238069 0.8832419 3.409903 10.117797 1.5367530 21.874253 0.2164953 0.57167291 3.822578 0.38825833 0.35960000 0.48096667 0.12136667 4.078781e-01 3.178685e-05 FALSE TRUE
ENST00000450014 ENSG00000113851 HEK293_OSMI2_6hA HEK293_TMG_6hB CRBN protein_coding protein_coding 23.42013 4.271204 45.49394 0.2238069 0.8832419 3.409903 1.479405 0.1698154 2.489952 0.1184891 0.26451796 3.797311 0.05290833 0.04166667 0.05483333 0.01316667 8.077611e-01 3.178685e-05 FALSE TRUE
ENST00000498700 ENSG00000113851 HEK293_OSMI2_6hA HEK293_TMG_6hB CRBN protein_coding retained_intron 23.42013 4.271204 45.49394 0.2238069 0.8832419 3.409903 4.885468 1.7135942 7.451846 0.1836084 0.01421778 2.114112 0.31424583 0.40126667 0.16390000 -0.23736667 3.178685e-05 3.178685e-05 FALSE TRUE
MSTRG.22411.8 ENSG00000113851 HEK293_OSMI2_6hA HEK293_TMG_6hB CRBN protein_coding   23.42013 4.271204 45.49394 0.2238069 0.8832419 3.409903 1.144347 0.0000000 2.317913 0.0000000 1.16431984 7.862893 0.02903333 0.00000000 0.05013333 0.05013333 5.966739e-01 3.178685e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000113851 E001 5.8097829 1.2668659096 9.319154e-01 9.680782e-01 3 3144628 3145499 872 - 0.675 0.285 -2.004
ENSG00000113851 E002 24.9912054 0.0511145265 8.803473e-01 9.414331e-01 3 3148992 3150010 1019 - 1.201 1.172 -0.103
ENSG00000113851 E003 182.9567010 0.0548867430 1.978873e-01 4.270075e-01 3 3150011 3150859 849 - 2.028 2.156 0.430
ENSG00000113851 E004 29.8524388 0.6144755151 4.680467e-01 6.787513e-01 3 3150860 3150882 23 - 1.264 1.360 0.337
ENSG00000113851 E005 104.4704580 0.0263198747 9.441524e-02 2.719496e-01 3 3150883 3150987 105 - 1.816 1.653 -0.553
ENSG00000113851 E006 86.5765786 0.0006505006 1.373923e-04 1.949563e-03 3 3150988 3151045 58 - 1.742 1.472 -0.922
ENSG00000113851 E007 40.7950372 0.2272071125 9.352056e-01 9.697725e-01 3 3151046 3152455 1410 - 1.408 1.346 -0.216
ENSG00000113851 E008 108.2384609 0.0122497316 1.134065e-01 3.048366e-01 3 3152456 3152587 132 - 1.828 1.703 -0.425
ENSG00000113851 E009 16.3382408 0.1252583206 6.502354e-01 8.037418e-01 3 3152588 3153423 836 - 1.018 1.086 0.249
ENSG00000113851 E010 72.2553307 0.0722995419 8.093466e-01 9.018094e-01 3 3153424 3153488 65 - 1.643 1.653 0.034
ENSG00000113851 E011 18.0724117 0.0074797151 1.532345e-03 1.383398e-02 3 3153489 3153959 471 - 1.020 1.375 1.262
ENSG00000113851 E012 89.8845907 0.0048875419 7.113711e-01 8.426723e-01 3 3153960 3154075 116 - 1.736 1.765 0.101
ENSG00000113851 E013 19.9075670 0.0186958769 4.946295e-01 6.972031e-01 3 3154076 3154549 474 - 1.098 1.198 0.357
ENSG00000113851 E014 11.7427693 0.0031703789 7.731323e-01 8.805523e-01 3 3154550 3154746 197 - 0.900 0.950 0.186
ENSG00000113851 E015 75.0007384 0.0005701521 5.290103e-01 7.213132e-01 3 3154747 3154831 85 - 1.663 1.628 -0.119
ENSG00000113851 E016 30.5189383 0.0055736527 3.190223e-01 5.587333e-01 3 3154832 3156089 1258 - 1.268 1.376 0.376
ENSG00000113851 E017 5.4045789 0.0073683827 3.417866e-01 5.795291e-01 3 3156090 3156218 129 - 0.597 0.774 0.743
ENSG00000113851 E018 72.3467972 0.0005740267 4.124299e-02 1.579620e-01 3 3156219 3156281 63 - 1.656 1.513 -0.485
ENSG00000113851 E019 3.4356712 0.2969446372 3.563849e-01 5.928608e-01 3 3156282 3156784 503 - 0.431 0.783 1.579
ENSG00000113851 E020 3.7956556 0.0078058844 6.197956e-01 7.836936e-01 3 3167430 3167633 204 - 0.493 0.598 0.493
ENSG00000113851 E021 145.7804901 0.0010002981 4.986579e-05 8.297431e-04 3 3167634 3167793 160 - 1.960 1.743 -0.733
ENSG00000113851 E022 34.5942933 0.0036609315 5.259158e-08 2.087231e-06 3 3172176 3172505 330 - 1.267 1.702 1.496
ENSG00000113851 E023 32.6199620 0.0022266977 1.465461e-11 1.222944e-09 3 3172506 3172646 141 - 1.225 1.743 1.782
ENSG00000113851 E024 2.9892447 0.1046326469 9.061382e-03 5.409847e-02 3 3172717 3172775 59 - 0.355 0.895 2.442
ENSG00000113851 E025 200.4414781 0.0014477420 9.349817e-01 9.697009e-01 3 3172776 3172915 140 - 2.080 2.092 0.040
ENSG00000113851 E026 95.6574845 0.0020622692 4.774690e-01 6.853644e-01 3 3172916 3172925 10 - 1.757 1.808 0.172
ENSG00000113851 E027 0.3228314 0.3543451599 1.000000e+00   3 3173887 3174058 172 - 0.083 0.001 -6.312
ENSG00000113851 E028 217.2983027 0.0041740307 4.721209e-01 6.816321e-01 3 3174059 3174261 203 - 2.118 2.092 -0.088
ENSG00000113851 E029 130.9552306 0.0020045044 4.448147e-01 6.620122e-01 3 3175163 3175266 104 - 1.901 1.869 -0.108
ENSG00000113851 E030 77.1703373 0.0030821217 8.111746e-01 9.029595e-01 3 3175267 3175269 3 - 1.674 1.666 -0.025
ENSG00000113851 E031 80.9729620 0.0010873415 5.619392e-01 7.446471e-01 3 3179621 3179727 107 - 1.696 1.667 -0.100