ENSG00000113810

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357388 ENSG00000113810 HEK293_OSMI2_6hA HEK293_TMG_6hB SMC4 protein_coding protein_coding 68.07437 30.09759 143.0693 3.213372 5.477854 2.248616 24.533548 3.947158 47.31170426 2.019988 1.74814284 3.5799654 0.24127500 0.12520000 0.3313333333 0.20613333 6.819871e-01 1.506637e-20 FALSE TRUE
ENST00000486711 ENSG00000113810 HEK293_OSMI2_6hA HEK293_TMG_6hB SMC4 protein_coding retained_intron 68.07437 30.09759 143.0693 3.213372 5.477854 2.248616 4.289371 6.751638 8.06644921 1.488315 2.14462829 0.2563485 0.07844583 0.21943333 0.0554000000 -0.16403333 4.205225e-03 1.506637e-20   FALSE
ENST00000497984 ENSG00000113810 HEK293_OSMI2_6hA HEK293_TMG_6hB SMC4 protein_coding processed_transcript 68.07437 30.09759 143.0693 3.213372 5.477854 2.248616 3.337351 0.000000 12.49522208 0.000000 1.54494935 10.2883150 0.02697083 0.00000000 0.0870000000 0.08700000 1.506637e-20 1.506637e-20 FALSE FALSE
MSTRG.24015.1 ENSG00000113810 HEK293_OSMI2_6hA HEK293_TMG_6hB SMC4 protein_coding   68.07437 30.09759 143.0693 3.213372 5.477854 2.248616 1.338539 2.062205 0.07019337 1.251855 0.04694943 -4.6915400 0.07164583 0.07043333 0.0005333333 -0.06990000 3.303887e-01 1.506637e-20 FALSE TRUE
MSTRG.24015.15 ENSG00000113810 HEK293_OSMI2_6hA HEK293_TMG_6hB SMC4 protein_coding   68.07437 30.09759 143.0693 3.213372 5.477854 2.248616 3.485764 1.220615 9.79488286 0.716472 1.76869844 2.9941213 0.05592083 0.04163333 0.0687000000 0.02706667 7.751674e-01 1.506637e-20 FALSE TRUE
MSTRG.24015.16 ENSG00000113810 HEK293_OSMI2_6hA HEK293_TMG_6hB SMC4 protein_coding   68.07437 30.09759 143.0693 3.213372 5.477854 2.248616 8.196305 9.020497 13.28812150 3.007974 2.20206042 0.5583452 0.23212500 0.29883333 0.0929000000 -0.20593333 2.853144e-01 1.506637e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000113810 E001 0.0000000       3 160399274 160399277 4 +      
ENSG00000113810 E002 1.8844016 0.2209736967 4.760595e-01 6.842935e-01 3 160399278 160399352 75 + 0.402 0.243 -1.019
ENSG00000113810 E003 2.0978048 0.2058090395 3.439192e-01 5.815464e-01 3 160399638 160399638 1 + 0.445 0.238 -1.294
ENSG00000113810 E004 2.2404394 0.2375829431 3.298634e-01 5.688185e-01 3 160399639 160399642 4 + 0.465 0.238 -1.396
ENSG00000113810 E005 2.0978048 0.2058090395 3.439192e-01 5.815464e-01 3 160399643 160399644 2 + 0.445 0.238 -1.294
ENSG00000113810 E006 2.2404394 0.2375829431 3.298634e-01 5.688185e-01 3 160399645 160399649 5 + 0.465 0.238 -1.396
ENSG00000113810 E007 2.4018551 0.2592232824 3.085304e-01 5.490873e-01 3 160399650 160399650 1 + 0.485 0.237 -1.498
ENSG00000113810 E008 3.1220429 0.4331666684 5.160409e-01 7.122878e-01 3 160399651 160399651 1 + 0.552 0.382 -0.864
ENSG00000113810 E009 18.5498579 0.7739718220 8.010349e-01 8.968792e-01 3 160399652 160399665 14 + 1.199 0.971 -0.825
ENSG00000113810 E010 25.2005953 0.8916073187 7.296721e-01 8.540425e-01 3 160399666 160399666 1 + 1.331 1.030 -1.070
ENSG00000113810 E011 38.9146669 0.9548431870 9.934510e-01 9.983634e-01 3 160399667 160399667 1 + 1.496 1.345 -0.520
ENSG00000113810 E012 45.1441663 0.9884982836 8.833867e-01 9.430436e-01 3 160399668 160399668 1 + 1.546 1.488 -0.198
ENSG00000113810 E013 61.6698936 1.0656614491 6.705042e-01 8.166316e-01 3 160399669 160399683 15 + 1.647 1.766 0.404
ENSG00000113810 E014 61.9984135 1.0405898081 5.951470e-01 7.671263e-01 3 160399684 160399697 14 + 1.639 1.804 0.558
ENSG00000113810 E015 74.4641567 1.3272265554 5.807917e-01 7.576861e-01 3 160399698 160399749 52 + 1.711 1.903 0.649
ENSG00000113810 E016 109.3454322 0.0319719308 2.464171e-01 4.840609e-01 3 160399750 160400481 732 + 1.915 1.915 0.002
ENSG00000113810 E017 42.2796808 0.0037797740 5.936652e-02 2.013783e-01 3 160400482 160400599 118 + 1.518 1.474 -0.151
ENSG00000113810 E018 36.9235453 0.0107048878 9.221512e-01 9.633401e-01 3 160400600 160400627 28 + 1.435 1.526 0.312
ENSG00000113810 E019 47.3882422 0.0216895176 8.656459e-01 9.335173e-01 3 160400628 160400821 194 + 1.534 1.651 0.399
ENSG00000113810 E020 113.9774512 0.0246025771 8.858893e-01 9.444686e-01 3 160400822 160400965 144 + 1.915 2.020 0.353
ENSG00000113810 E021 72.2814620 0.0159208634 6.598204e-01 8.098808e-01 3 160401915 160401923 9 + 1.725 1.795 0.239
ENSG00000113810 E022 129.4969163 0.0264864062 1.973790e-01 4.263591e-01 3 160401924 160401989 66 + 1.987 1.989 0.006
ENSG00000113810 E023 194.8823878 0.0092088317 6.324855e-04 6.861104e-03 3 160401990 160402093 104 + 2.177 2.082 -0.319
ENSG00000113810 E024 268.9763678 0.0080068489 1.332828e-05 2.691921e-04 3 160402676 160402808 133 + 2.321 2.194 -0.422
ENSG00000113810 E025 209.2185845 0.0096676647 2.637500e-05 4.827116e-04 3 160402809 160402867 59 + 2.215 2.068 -0.489
ENSG00000113810 E026 0.0000000       3 160403991 160404071 81 +      
ENSG00000113810 E027 218.9467163 0.0043015074 2.150921e-08 9.366254e-07 3 160404328 160404377 50 + 2.236 2.071 -0.549
ENSG00000113810 E028 363.6627060 0.0053477961 1.439938e-08 6.521103e-07 3 160404378 160404498 121 + 2.454 2.303 -0.502
ENSG00000113810 E029 187.8623443 0.0041933742 9.354604e-07 2.680774e-05 3 160404499 160404504 6 + 2.167 2.034 -0.447
ENSG00000113810 E030 4.1942288 0.2205886002 6.642263e-01 8.125166e-01 3 160411758 160411919 162 + 0.613 0.603 -0.041
ENSG00000113810 E031 336.3173104 0.0030853123 5.419853e-13 5.843909e-11 3 160411920 160411977 58 + 2.424 2.243 -0.604
ENSG00000113810 E032 326.1571570 0.0057756670 9.178437e-11 6.560226e-09 3 160411978 160412021 44 + 2.413 2.207 -0.687
ENSG00000113810 E033 351.7991866 0.0063688388 8.671976e-11 6.227066e-09 3 160412022 160412084 63 + 2.446 2.237 -0.697
ENSG00000113810 E034 250.9231760 0.0124910917 2.470132e-05 4.569058e-04 3 160412326 160412334 9 + 2.295 2.133 -0.539
ENSG00000113810 E035 375.3450106 0.0070705604 1.868210e-06 4.909703e-05 3 160412335 160412453 119 + 2.464 2.339 -0.419
ENSG00000113810 E036 3.0749025 0.0090194483 8.223639e-02 2.491905e-01 3 160412454 160412529 76 + 0.430 0.791 1.617
ENSG00000113810 E037 11.4393870 0.0050135868 8.213363e-01 9.087667e-01 3 160412530 160412849 320 + 0.962 1.082 0.440
ENSG00000113810 E038 0.1614157 0.0334129103 1.000000e+00   3 160412850 160412852 3 + 0.057 0.001 -6.894
ENSG00000113810 E039 334.4823254 0.0026616523 2.637703e-04 3.361923e-03 3 160413473 160413613 141 + 2.402 2.374 -0.092
ENSG00000113810 E040 17.7348888 0.1093508917 9.142079e-01 9.592078e-01 3 160413614 160413754 141 + 1.127 1.242 0.407
ENSG00000113810 E041 34.6266494 0.0944550239 1.528308e-01 3.663797e-01 3 160414023 160414366 344 + 1.440 1.339 -0.348
ENSG00000113810 E042 242.1691188 0.0036932409 2.246677e-02 1.041232e-01 3 160414367 160414437 71 + 2.256 2.262 0.019
ENSG00000113810 E043 251.6859041 0.0002762025 3.693333e-03 2.743863e-02 3 160414438 160414517 80 + 2.272 2.287 0.051
ENSG00000113810 E044 347.3322538 0.0136478446 2.007851e-01 4.306981e-01 3 160416251 160416415 165 + 2.407 2.437 0.100
ENSG00000113810 E045 11.7458309 0.0775892814 6.494611e-01 8.030977e-01 3 160416416 160416627 212 + 0.981 0.994 0.046
ENSG00000113810 E046 9.9190509 0.0090542170 8.034223e-01 8.982988e-01 3 160417624 160417722 99 + 0.906 0.961 0.208
ENSG00000113810 E047 562.5871174 0.0067064514 1.978598e-03 1.692668e-02 3 160417723 160417956 234 + 2.626 2.594 -0.109
ENSG00000113810 E048 547.6383892 0.0075362822 2.258032e-04 2.955420e-03 3 160419358 160419543 186 + 2.620 2.549 -0.235
ENSG00000113810 E049 4.5934228 0.0096088986 5.338572e-01 7.248242e-01 3 160420582 160420739 158 + 0.612 0.791 0.742
ENSG00000113810 E050 538.0031334 0.0063953257 8.835604e-04 8.961352e-03 3 160420740 160420901 162 + 2.608 2.564 -0.146
ENSG00000113810 E051 713.5062029 0.0072729374 2.295780e-03 1.902485e-02 3 160423425 160423650 226 + 2.730 2.690 -0.131
ENSG00000113810 E052 462.7332791 0.0082533439 4.313504e-02 1.629080e-01 3 160423761 160423840 80 + 2.536 2.531 -0.016
ENSG00000113810 E053 563.2572439 0.0036487735 3.527735e-01 5.898012e-01 3 160424867 160425019 153 + 2.610 2.677 0.222
ENSG00000113810 E054 493.9802676 0.0031176175 5.091161e-01 7.072535e-01 3 160426074 160426200 127 + 2.551 2.630 0.261
ENSG00000113810 E055 307.3978390 0.0015366519 8.175930e-01 9.066968e-01 3 160428753 160428795 43 + 2.341 2.450 0.362
ENSG00000113810 E056 553.2838478 0.0030303746 4.686617e-01 6.791310e-01 3 160428796 160428942 147 + 2.600 2.677 0.257
ENSG00000113810 E057 483.1920467 0.0020471001 6.491071e-01 8.029232e-01 3 160430599 160430743 145 + 2.540 2.627 0.291
ENSG00000113810 E058 9.9442965 0.0283845125 7.997538e-01 8.962229e-01 3 160430744 160430928 185 + 0.899 1.025 0.471
ENSG00000113810 E059 6.1226576 0.0072314219 3.564157e-01 5.928671e-01 3 160430929 160431031 103 + 0.706 0.923 0.856
ENSG00000113810 E060 497.7813180 0.0020927512 1.064689e-01 2.931209e-01 3 160431032 160431205 174 + 2.541 2.688 0.490
ENSG00000113810 E061 644.7637125 0.0068026571 1.246389e-04 1.794840e-03 3 160431643 160431825 183 + 2.626 2.882 0.851
ENSG00000113810 E062 665.9191378 0.0273732467 7.281465e-05 1.147300e-03 3 160432283 160432515 233 + 2.600 2.992 1.303
ENSG00000113810 E063 433.3548564 1.8003683699 3.317628e-01 5.706107e-01 3 160433026 160433209 184 + 2.368 2.887 1.729
ENSG00000113810 E064 1038.1147082 2.0589834650 3.337891e-01 5.723856e-01 3 160433657 160435011 1355 + 2.738 3.279 1.797