ENSG00000113649

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296702 ENSG00000113649 HEK293_OSMI2_6hA HEK293_TMG_6hB TCERG1 protein_coding protein_coding 45.28259 30.32556 76.00261 8.237227 0.328064 1.325229 4.148743 4.385994 5.4136617 1.428795 0.2742249 0.3030779 0.09268750 0.1390667 0.07126667 -0.06780000 6.088913e-03 2.942178e-27 FALSE TRUE
ENST00000394421 ENSG00000113649 HEK293_OSMI2_6hA HEK293_TMG_6hB TCERG1 protein_coding protein_coding 45.28259 30.32556 76.00261 8.237227 0.328064 1.325229 20.226143 17.261979 36.0664939 5.624156 1.7663569 1.0626257 0.41160000 0.5446333 0.47436667 -0.07026667 7.460828e-01 2.942178e-27 FALSE TRUE
ENST00000505285 ENSG00000113649 HEK293_OSMI2_6hA HEK293_TMG_6hB TCERG1 protein_coding retained_intron 45.28259 30.32556 76.00261 8.237227 0.328064 1.325229 4.149622 0.000000 10.8470586 0.000000 0.8775545 10.0844176 0.06149167 0.0000000 0.14273333 0.14273333 2.942178e-27 2.942178e-27 FALSE FALSE
ENST00000515203 ENSG00000113649 HEK293_OSMI2_6hA HEK293_TMG_6hB TCERG1 protein_coding processed_transcript 45.28259 30.32556 76.00261 8.237227 0.328064 1.325229 2.375161 0.000000 4.2740449 0.000000 0.2952146 8.7428298 0.03716667 0.0000000 0.05620000 0.05620000 1.073537e-18 2.942178e-27 FALSE FALSE
MSTRG.27114.16 ENSG00000113649 HEK293_OSMI2_6hA HEK293_TMG_6hB TCERG1 protein_coding   45.28259 30.32556 76.00261 8.237227 0.328064 1.325229 2.706048 3.910462 0.1951836 1.837896 0.1105212 -4.2560365 0.10308333 0.1138000 0.00260000 -0.11120000 1.597473e-03 2.942178e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000113649 E001 2.5989257 0.0092586558 2.654661e-02 1.169145e-01 5 146447217 146447310 94 + 0.646 0.268 -2.005
ENSG00000113649 E002 1.4343360 0.0125422612 7.619236e-02 2.371209e-01 5 146447311 146447311 1 + 0.471 0.154 -2.199
ENSG00000113649 E003 3.5221056 0.0225110714 1.435031e-02 7.569539e-02 5 146447312 146447325 14 + 0.768 0.357 -1.931
ENSG00000113649 E004 6.9831952 0.0769952384 9.851455e-01 9.943525e-01 5 146447326 146447330 5 + 0.903 0.888 -0.057
ENSG00000113649 E005 9.7736859 0.0207287197 8.211596e-01 9.086760e-01 5 146447331 146447332 2 + 1.011 1.048 0.134
ENSG00000113649 E006 35.2846241 0.0070610201 9.052250e-02 2.647405e-01 5 146447333 146447345 13 + 1.584 1.475 -0.375
ENSG00000113649 E007 91.1771018 0.0026048051 5.162607e-01 7.124348e-01 5 146447346 146447408 63 + 1.959 1.951 -0.026
ENSG00000113649 E008 256.3084689 0.0002230973 2.216350e-04 2.912313e-03 5 146455056 146455281 226 + 2.422 2.359 -0.208
ENSG00000113649 E009 242.6747149 0.0001982041 2.267770e-05 4.254994e-04 5 146457183 146457335 153 + 2.402 2.325 -0.259
ENSG00000113649 E010 167.8273065 0.0002913176 9.226094e-01 9.635994e-01 5 146458884 146458991 108 + 2.210 2.232 0.075
ENSG00000113649 E011 95.9598324 0.0020392594 1.148969e-02 6.434974e-02 5 146458992 146459051 60 + 1.927 2.058 0.440
ENSG00000113649 E012 43.5331787 0.0082177960 3.012888e-02 1.277197e-01 5 146459052 146459063 12 + 1.565 1.747 0.620
ENSG00000113649 E013 43.4620796 0.0035768356 2.073427e-03 1.755750e-02 5 146459064 146459075 12 + 1.550 1.761 0.717
ENSG00000113649 E014 45.5327132 0.0012647217 1.541746e-03 1.390019e-02 5 146459076 146459081 6 + 1.578 1.773 0.659
ENSG00000113649 E015 83.2151858 0.0026626284 6.219765e-02 2.077369e-01 5 146459082 146459135 54 + 1.873 1.985 0.374
ENSG00000113649 E016 83.8226574 0.0025481601 4.144673e-01 6.394192e-01 5 146459136 146459153 18 + 1.895 1.959 0.215
ENSG00000113649 E017 119.6456218 0.0068760396 5.972593e-01 7.685131e-01 5 146459154 146459214 61 + 2.053 2.105 0.175
ENSG00000113649 E018 211.8790644 0.0072767916 4.555737e-01 6.699476e-01 5 146459215 146459337 123 + 2.322 2.308 -0.045
ENSG00000113649 E019 7.4568116 0.0042744708 2.635670e-03 2.118603e-02 5 146462018 146462056 39 + 1.022 0.644 -1.481
ENSG00000113649 E020 7.8609943 0.0779662879 3.099258e-02 1.303205e-01 5 146462057 146462096 40 + 1.048 0.644 -1.579
ENSG00000113649 E021 360.1464115 0.0012548942 3.078949e-04 3.809323e-03 5 146463551 146463793 243 + 2.571 2.503 -0.226
ENSG00000113649 E022 23.7051460 0.0028673871 1.940852e-01 4.222410e-01 5 146468341 146468403 63 + 1.333 1.457 0.427
ENSG00000113649 E023 296.1282113 0.0005217615 3.647735e-03 2.718401e-02 5 146469544 146469744 201 + 2.477 2.434 -0.144
ENSG00000113649 E024 0.0000000       5 146469745 146469809 65 +      
ENSG00000113649 E025 109.2631623 0.0004045697 9.625151e-01 9.832088e-01 5 146470636 146470640 5 + 2.021 2.045 0.078
ENSG00000113649 E026 222.4832646 0.0002480905 4.210021e-01 6.444550e-01 5 146470641 146470748 108 + 2.337 2.342 0.017
ENSG00000113649 E027 222.9220028 0.0018734346 3.987906e-02 1.543985e-01 5 146471488 146471576 89 + 2.354 2.312 -0.140
ENSG00000113649 E028 0.6600180 0.0193874923 1.142809e-01   5 146478418 146478492 75 + 0.296 0.001 -9.569
ENSG00000113649 E029 181.8832398 0.0018151048 3.317345e-03 2.530825e-02 5 146478493 146478524 32 + 2.277 2.200 -0.257
ENSG00000113649 E030 327.4933566 0.0006269355 5.365105e-06 1.225940e-04 5 146478525 146478653 129 + 2.535 2.452 -0.277
ENSG00000113649 E031 274.2078107 0.0017953662 2.548551e-03 2.064817e-02 5 146479855 146479911 57 + 2.454 2.382 -0.240
ENSG00000113649 E032 283.4477202 0.0002315080 1.185420e-02 6.583758e-02 5 146480028 146480094 67 + 2.456 2.424 -0.106
ENSG00000113649 E033 20.3832386 0.0978763085 1.840566e-02 9.037374e-02 5 146480095 146480518 424 + 1.431 1.010 -1.492
ENSG00000113649 E034 14.5225917 0.0022634471 9.062380e-01 9.551918e-01 5 146481150 146481175 26 + 1.167 1.201 0.123
ENSG00000113649 E035 15.2546635 0.0022575339 6.963587e-01 8.331861e-01 5 146481176 146481200 25 + 1.202 1.190 -0.042
ENSG00000113649 E036 45.5051281 0.2730913751 6.400526e-02 2.116779e-01 5 146481201 146482591 1391 + 1.770 1.323 -1.531
ENSG00000113649 E037 350.6963421 0.0002550656 5.920075e-01 7.650368e-01 5 146482592 146482727 136 + 2.532 2.545 0.045
ENSG00000113649 E038 21.8311558 0.0542115994 4.910913e-03 3.415357e-02 5 146482728 146482808 81 + 1.454 1.036 -1.478
ENSG00000113649 E039 301.4501343 0.0001869958 7.406727e-01 8.608335e-01 5 146483540 146483629 90 + 2.463 2.480 0.057
ENSG00000113649 E040 0.8737109 0.0460170819 8.975378e-01   5 146492869 146492919 51 + 0.239 0.269 0.223
ENSG00000113649 E041 333.9699918 0.0001912713 1.707951e-01 3.915618e-01 5 146492920 146493038 119 + 2.516 2.512 -0.013
ENSG00000113649 E042 390.9725856 0.0001682865 2.946087e-01 5.351688e-01 5 146498536 146498686 151 + 2.579 2.584 0.016
ENSG00000113649 E043 8.3356139 0.0187574972 1.305801e-01 3.327144e-01 5 146499573 146499971 399 + 1.012 0.818 -0.737
ENSG00000113649 E044 10.4434563 0.0127808290 5.822791e-02 1.987837e-01 5 146503032 146503374 343 + 1.120 0.915 -0.754
ENSG00000113649 E045 278.8659281 0.0007882738 8.288818e-02 2.505129e-01 5 146503375 146503418 44 + 2.442 2.422 -0.065
ENSG00000113649 E046 328.1157756 0.0001804253 9.159724e-03 5.453605e-02 5 146503419 146503470 52 + 2.516 2.486 -0.097
ENSG00000113649 E047 358.5042458 0.0001605973 2.625570e-02 1.160910e-01 5 146503471 146503539 69 + 2.550 2.531 -0.064
ENSG00000113649 E048 197.2669076 0.0002541546 3.149904e-01 5.551214e-01 5 146503824 146503827 4 + 2.287 2.285 -0.006
ENSG00000113649 E049 451.1940363 0.0001567610 7.842269e-01 8.870372e-01 5 146503828 146504006 179 + 2.633 2.663 0.098
ENSG00000113649 E050 2.1702139 0.0973033081 6.974805e-01 8.339164e-01 5 146504007 146504202 196 + 0.509 0.431 -0.394
ENSG00000113649 E051 3.4961467 0.2818921238 8.919268e-01 9.475646e-01 5 146504364 146504494 131 + 0.651 0.608 -0.189
ENSG00000113649 E052 1.9430892 0.1285380654 8.585529e-01 9.295976e-01 5 146505505 146505621 117 + 0.474 0.430 -0.228
ENSG00000113649 E053 446.9231956 0.0024589682 4.336065e-01 6.539757e-01 5 146507028 146507207 180 + 2.623 2.660 0.121
ENSG00000113649 E054 2.2083937 0.0551084084 9.390546e-01 9.718355e-01 5 146507208 146507348 141 + 0.505 0.495 -0.049
ENSG00000113649 E055 10.9458555 0.0131369423 3.229103e-01 5.622294e-01 5 146507371 146507744 374 + 1.097 0.997 -0.367
ENSG00000113649 E056 5.2414301 0.0054042139 3.873250e-01 6.183845e-01 5 146507745 146507778 34 + 0.821 0.721 -0.400
ENSG00000113649 E057 3.7422452 0.3272294928 8.907041e-01 9.470274e-01 5 146507779 146507872 94 + 0.682 0.620 -0.262
ENSG00000113649 E058 352.1065800 0.0002222448 9.711539e-01 9.874222e-01 5 146507873 146507956 84 + 2.527 2.552 0.082
ENSG00000113649 E059 343.4835782 0.0005337103 5.496883e-05 9.035010e-04 5 146509145 146509245 101 + 2.480 2.591 0.369
ENSG00000113649 E060 9.6453227 0.0044602560 8.417930e-01 9.204604e-01 5 146510067 146510115 49 + 0.991 1.034 0.156
ENSG00000113649 E061 11.1404935 0.0169402382 9.866706e-01 9.951876e-01 5 146510116 146510160 45 + 1.062 1.068 0.021
ENSG00000113649 E062 1.9046037 0.0113584523 1.133395e-01 3.047155e-01 5 146510161 146510271 111 + 0.537 0.267 -1.523
ENSG00000113649 E063 1428.5125099 0.0048494623 4.391797e-08 1.773670e-06 5 146510441 146511961 1521 + 3.059 3.250 0.635