ENSG00000113621

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358387 ENSG00000113621 HEK293_OSMI2_6hA HEK293_TMG_6hB TXNDC15 protein_coding protein_coding 24.99889 11.96007 32.35307 0.7817116 0.9467438 1.434917 8.2745579 2.5082478 10.7892416 0.2942495 0.02901010 2.100438 0.31063333 0.20866667 0.334033333 0.12536667 0.0169233035 0.0003455067 FALSE TRUE
ENST00000505174 ENSG00000113621 HEK293_OSMI2_6hA HEK293_TMG_6hB TXNDC15 protein_coding retained_intron 24.99889 11.96007 32.35307 0.7817116 0.9467438 1.434917 0.5088704 0.8121196 0.2918808 0.2527619 0.01158731 -1.445369 0.03378333 0.06586667 0.009033333 -0.05683333 0.0003455067 0.0003455067 FALSE TRUE
ENST00000506916 ENSG00000113621 HEK293_OSMI2_6hA HEK293_TMG_6hB TXNDC15 protein_coding protein_coding 24.99889 11.96007 32.35307 0.7817116 0.9467438 1.434917 7.5856382 4.0701353 9.3508723 0.3659780 0.77280747 1.198026 0.28077083 0.34286667 0.288166667 -0.05470000 0.7695163094 0.0003455067 FALSE FALSE
ENST00000508779 ENSG00000113621 HEK293_OSMI2_6hA HEK293_TMG_6hB TXNDC15 protein_coding protein_coding 24.99889 11.96007 32.35307 0.7817116 0.9467438 1.434917 4.4829162 2.2639592 4.6419802 0.7566505 0.33844048 1.032639 0.20635833 0.19660000 0.144300000 -0.05230000 0.9195949741 0.0003455067 FALSE TRUE
ENST00000509954 ENSG00000113621 HEK293_OSMI2_6hA HEK293_TMG_6hB TXNDC15 protein_coding protein_coding 24.99889 11.96007 32.35307 0.7817116 0.9467438 1.434917 2.8631690 1.5405119 6.6598200 0.8335226 0.41256693 2.104903 0.11505000 0.12663333 0.205433333 0.07880000 0.8059776644 0.0003455067 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000113621 E001 8.1215775 0.0245728688 6.972599e-02 2.242374e-01 5 134874371 134874375 5 + 0.847 1.078 0.861
ENSG00000113621 E002 33.1790551 0.0020732997 5.652963e-03 3.801089e-02 5 134874376 134874396 21 + 1.440 1.616 0.605
ENSG00000113621 E003 84.9384124 0.0006304917 5.227008e-01 7.168426e-01 5 134874397 134874483 87 + 1.889 1.915 0.087
ENSG00000113621 E004 82.8658730 0.0004663454 9.858132e-01 9.947416e-01 5 134874484 134874530 47 + 1.884 1.885 0.003
ENSG00000113621 E005 1.5464525 0.0128391256 3.309445e-03 2.525818e-02 5 134875096 134875188 93 + 0.152 0.653 3.065
ENSG00000113621 E006 1.4093547 0.5009926494 1.272637e-02 6.935467e-02 5 134875342 134875395 54 + 0.000 0.716 12.962
ENSG00000113621 E007 60.6962992 0.0007250027 9.966525e-01 1.000000e+00 5 134887695 134887700 6 + 1.751 1.751 -0.001
ENSG00000113621 E008 259.3590697 0.0015102375 1.552002e-01 3.697453e-01 5 134887701 134888152 452 + 2.366 2.403 0.124
ENSG00000113621 E009 38.3751593 0.0010247953 1.659394e-01 3.850560e-01 5 134888153 134888182 30 + 1.529 1.611 0.281
ENSG00000113621 E010 19.2306715 0.0408564690 3.331667e-11 2.602900e-09 5 134892178 134893491 1314 + 0.794 1.669 3.127
ENSG00000113621 E011 91.2214768 0.0004545880 7.924349e-03 4.896853e-02 5 134893492 134893625 134 + 1.892 1.994 0.342
ENSG00000113621 E012 60.4127505 0.0007702083 1.851104e-01 4.106740e-01 5 134893626 134893655 30 + 1.728 1.791 0.215
ENSG00000113621 E013 0.4873834 0.1078842700 2.144478e-01   5 134896021 134896293 273 + 0.082 0.302 2.268
ENSG00000113621 E014 50.9317050 0.0007677614 3.158709e-01 5.558771e-01 5 134896294 134896305 12 + 1.658 1.711 0.178
ENSG00000113621 E015 107.3422720 0.0003838401 1.274398e-01 3.277764e-01 5 134896306 134896424 119 + 1.978 2.032 0.182
ENSG00000113621 E016 219.9307750 0.0002856257 5.661385e-02 1.951198e-01 5 134899489 134899936 448 + 2.318 2.271 -0.159
ENSG00000113621 E017 86.8977068 0.0022347577 2.389463e-09 1.295199e-07 5 134899937 134900154 218 + 1.975 1.680 -0.995
ENSG00000113621 E018 128.1908531 0.0018299762 2.072594e-08 9.059824e-07 5 134900155 134901065 911 + 2.127 1.903 -0.751
ENSG00000113621 E019 45.5596304 0.0517268909 1.875545e-02 9.156574e-02 5 134901066 134901635 570 + 1.693 1.416 -0.948