ENSG00000113569

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000231498 ENSG00000113569 HEK293_OSMI2_6hA HEK293_TMG_6hB NUP155 protein_coding protein_coding 24.6907 9.61564 41.01369 2.089246 1.858873 2.091503 10.056962 5.9649965 13.906888 1.23650173 0.3280024 1.219827 0.46462500 0.62376667 0.33983333 -0.28393333 1.638131e-05 1.519181e-27 FALSE TRUE
ENST00000381843 ENSG00000113569 HEK293_OSMI2_6hA HEK293_TMG_6hB NUP155 protein_coding protein_coding 24.6907 9.61564 41.01369 2.089246 1.858873 2.091503 7.139130 0.4981935 16.355846 0.19434197 1.1599867 5.009166 0.20908333 0.05273333 0.39796667 0.34523333 9.399843e-08 1.519181e-27 FALSE TRUE
ENST00000502533 ENSG00000113569 HEK293_OSMI2_6hA HEK293_TMG_6hB NUP155 protein_coding processed_transcript 24.6907 9.61564 41.01369 2.089246 1.858873 2.091503 1.745207 2.5715190 0.000000 0.82364414 0.0000000 -8.012076 0.15297500 0.25843333 0.00000000 -0.25843333 1.519181e-27 1.519181e-27 FALSE TRUE
ENST00000513532 ENSG00000113569 HEK293_OSMI2_6hA HEK293_TMG_6hB NUP155 protein_coding protein_coding 24.6907 9.61564 41.01369 2.089246 1.858873 2.091503 2.067154 0.1221613 3.860698 0.06787719 0.4475446 4.872223 0.05749167 0.01526667 0.09403333 0.07876667 3.213715e-02 1.519181e-27 FALSE TRUE
MSTRG.26073.3 ENSG00000113569 HEK293_OSMI2_6hA HEK293_TMG_6hB NUP155 protein_coding   24.6907 9.61564 41.01369 2.089246 1.858873 2.091503 2.500470 0.0000000 4.710680 0.00000000 0.3901007 8.882851 0.06915833 0.00000000 0.11446667 0.11446667 2.253024e-16 1.519181e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000113569 E001 821.8716679 0.0011815819 6.586767e-44 1.452707e-40 5 37288137 37291619 3483 - 2.750 3.041 0.966
ENSG00000113569 E002 13.0236826 0.0025083081 7.407832e-02 2.328934e-01 5 37291620 37291632 13 - 1.016 1.218 0.728
ENSG00000113569 E003 66.6204388 0.0044031043 1.251799e-03 1.180434e-02 5 37291633 37291837 205 - 1.693 1.895 0.682
ENSG00000113569 E004 40.2200614 0.0110721042 2.283973e-02 1.054441e-01 5 37291838 37291838 1 - 1.482 1.676 0.664
ENSG00000113569 E005 79.5464818 0.0005355327 1.282919e-05 2.603599e-04 5 37291839 37291899 61 - 1.767 1.980 0.718
ENSG00000113569 E006 149.4394254 0.0019286588 1.978935e-05 3.788398e-04 5 37291900 37292038 139 - 2.045 2.228 0.614
ENSG00000113569 E007 185.0286693 0.0016560588 4.033291e-04 4.762851e-03 5 37292879 37292985 107 - 2.149 2.294 0.486
ENSG00000113569 E008 0.8296159 0.1191267770 1.000000e+00   5 37292986 37293174 189 - 0.222 0.211 -0.092
ENSG00000113569 E009 224.8006118 0.0002527900 1.711633e-03 1.509685e-02 5 37294329 37294465 137 - 2.243 2.351 0.358
ENSG00000113569 E010 183.5126840 0.0014163175 1.074655e-03 1.048977e-02 5 37298868 37298978 111 - 2.150 2.282 0.441
ENSG00000113569 E011 195.2269112 0.0037262751 8.225535e-03 5.036179e-02 5 37299448 37299568 121 - 2.176 2.304 0.426
ENSG00000113569 E012 0.7920539 0.0721759281 1.000000e+00   5 37301014 37301436 423 - 0.221 0.211 -0.090
ENSG00000113569 E013 205.6784812 0.0006791968 1.291711e-01 3.304545e-01 5 37301437 37301550 114 - 2.217 2.283 0.221
ENSG00000113569 E014 216.4692690 0.0002845427 1.003632e-01 2.824459e-01 5 37302779 37302908 130 - 2.239 2.306 0.224
ENSG00000113569 E015 217.9604161 0.0003196234 7.221509e-01 8.493984e-01 5 37303260 37303414 155 - 2.252 2.283 0.103
ENSG00000113569 E016 0.6600180 0.0193874923 3.614511e-01   5 37303415 37303416 2 - 0.223 0.000 -10.008
ENSG00000113569 E017 167.6583621 0.0003071513 5.870715e-01 7.616657e-01 5 37304739 37304843 105 - 2.136 2.175 0.128
ENSG00000113569 E018 234.4179700 0.0003205572 4.467914e-01 6.633018e-01 5 37305057 37305210 154 - 2.278 2.320 0.139
ENSG00000113569 E019 226.7369508 0.0005998077 1.387897e-01 3.456523e-01 5 37307297 37307432 136 - 2.278 2.254 -0.080
ENSG00000113569 E020 216.9669479 0.0003609085 4.489287e-02 1.673400e-01 5 37309129 37309267 139 - 2.261 2.221 -0.134
ENSG00000113569 E021 0.1723744 0.0525025665 1.233592e-01   5 37309404 37309572 169 - 0.000 0.210 11.748
ENSG00000113569 E022 230.1281667 0.0002820137 6.610057e-02 2.163184e-01 5 37310552 37310743 192 - 2.286 2.252 -0.111
ENSG00000113569 E023 194.5270790 0.0002928224 1.439466e-01 3.533143e-01 5 37314198 37314328 131 - 2.211 2.186 -0.085
ENSG00000113569 E024 161.2382037 0.0002848395 2.610663e-01 5.001023e-01 5 37317988 37318085 98 - 2.129 2.111 -0.059
ENSG00000113569 E025 159.4363996 0.0055688026 5.401783e-01 7.291237e-01 5 37323992 37324107 116 - 2.121 2.113 -0.026
ENSG00000113569 E026 145.6492067 0.0009075300 7.618411e-03 4.755431e-02 5 37325901 37325967 67 - 2.098 2.013 -0.284
ENSG00000113569 E027 220.8689296 0.0003941870 8.015416e-06 1.732691e-04 5 37327629 37327776 148 - 2.285 2.166 -0.398
ENSG00000113569 E028 146.2221131 0.0002769544 1.185742e-04 1.721521e-03 5 37328358 37328420 63 - 2.109 1.985 -0.413
ENSG00000113569 E029 122.4074906 0.0003302441 3.986108e-02 1.543606e-01 5 37329190 37329278 89 - 2.020 1.960 -0.204
ENSG00000113569 E030 109.6445426 0.0004489609 7.902719e-02 2.428798e-01 5 37330038 37330132 95 - 1.972 1.919 -0.178
ENSG00000113569 E031 146.0752489 0.0024983025 4.301346e-05 7.322249e-04 5 37331685 37331795 111 - 2.115 1.952 -0.545
ENSG00000113569 E032 185.0983988 0.0008694571 1.738003e-04 2.378731e-03 5 37333463 37333633 171 - 2.209 2.097 -0.373
ENSG00000113569 E033 118.3251983 0.0003830771 8.440016e-03 5.133811e-02 5 37337818 37337918 101 - 2.013 1.926 -0.292
ENSG00000113569 E034 147.0552950 0.0003053661 2.487945e-05 4.596000e-04 5 37341090 37341242 153 - 2.115 1.977 -0.462
ENSG00000113569 E035 0.6058878 0.1129711023 4.010769e-01   5 37342397 37342548 152 - 0.221 0.000 -10.001
ENSG00000113569 E036 121.8486482 0.0005147913 2.796566e-06 6.993064e-05 5 37342549 37342646 98 - 2.039 1.860 -0.602
ENSG00000113569 E037 112.1662222 0.0004539471 1.031088e-05 2.154047e-04 5 37348505 37348596 92 - 2.003 1.829 -0.582
ENSG00000113569 E038 95.4563749 0.0003992318 1.615234e-05 3.182918e-04 5 37349172 37349245 74 - 1.935 1.751 -0.620
ENSG00000113569 E039 124.1724280 0.0006499651 1.091158e-05 2.264497e-04 5 37350160 37350265 106 - 2.044 1.879 -0.556
ENSG00000113569 E040 161.3939173 0.0002758325 3.492554e-10 2.211469e-08 5 37351190 37351356 167 - 2.164 1.951 -0.714
ENSG00000113569 E041 139.1955599 0.0004781617 1.256465e-10 8.718714e-09 5 37352737 37352829 93 - 2.107 1.864 -0.818
ENSG00000113569 E042 145.9585241 0.0012979606 1.458542e-08 6.598135e-07 5 37358081 37358151 71 - 2.125 1.905 -0.736
ENSG00000113569 E043 140.1136365 0.0085604069 3.405600e-04 4.144981e-03 5 37363888 37363984 97 - 2.103 1.913 -0.636
ENSG00000113569 E044 160.0957205 0.0011954812 3.932478e-05 6.786814e-04 5 37364247 37364384 138 - 2.153 2.012 -0.472
ENSG00000113569 E045 6.6987019 0.0043895831 9.632577e-02 2.753047e-01 5 37370666 37370820 155 - 0.857 0.614 -0.995
ENSG00000113569 E046 119.5005602 0.0004186304 3.107688e-03 2.406432e-02 5 37370821 37371126 306 - 2.018 1.916 -0.341