ENSG00000113456

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325577 ENSG00000113456 HEK293_OSMI2_6hA HEK293_TMG_6hB RAD1 protein_coding nonsense_mediated_decay 26.40911 14.13949 37.885 2.298904 0.2576119 1.421257 9.247757 4.256991 15.777203 1.0445728 0.9250977 1.8874648 0.33911250 0.29996667 0.41683333 0.11686667 4.691746e-01 2.653546e-06 FALSE TRUE
ENST00000382038 ENSG00000113456 HEK293_OSMI2_6hA HEK293_TMG_6hB RAD1 protein_coding protein_coding 26.40911 14.13949 37.885 2.298904 0.2576119 1.421257 5.287693 1.303751 8.014720 0.2043005 0.5722412 2.6107595 0.17997500 0.09236667 0.21176667 0.11940000 4.397266e-04 2.653546e-06 FALSE TRUE
MSTRG.26059.1 ENSG00000113456 HEK293_OSMI2_6hA HEK293_TMG_6hB RAD1 protein_coding   26.40911 14.13949 37.885 2.298904 0.2576119 1.421257 3.319744 3.685972 2.204451 0.9819257 0.2389714 -0.7390050 0.15016667 0.25983333 0.05826667 -0.20156667 6.974537e-04 2.653546e-06 FALSE TRUE
MSTRG.26059.10 ENSG00000113456 HEK293_OSMI2_6hA HEK293_TMG_6hB RAD1 protein_coding   26.40911 14.13949 37.885 2.298904 0.2576119 1.421257 2.076589 0.000000 3.937560 0.0000000 1.2782626 8.6248174 0.06898333 0.00000000 0.10360000 0.10360000 2.653546e-06 2.653546e-06 FALSE TRUE
MSTRG.26059.4 ENSG00000113456 HEK293_OSMI2_6hA HEK293_TMG_6hB RAD1 protein_coding   26.40911 14.13949 37.885 2.298904 0.2576119 1.421257 1.515728 1.545396 1.248143 0.5069852 0.2268187 -0.3059861 0.06917083 0.10503333 0.03286667 -0.07216667 1.064041e-01 2.653546e-06 FALSE TRUE
MSTRG.26059.8 ENSG00000113456 HEK293_OSMI2_6hA HEK293_TMG_6hB RAD1 protein_coding   26.40911 14.13949 37.885 2.298904 0.2576119 1.421257 1.667078 1.621669 2.168234 0.8951070 1.4000622 0.4168099 0.07018333 0.11686667 0.05736667 -0.05950000 9.390760e-01 2.653546e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000113456 E001 0.9762444 0.0154267838 5.861902e-02   5 34897033 34897069 37 - 0.149 0.483 2.321
ENSG00000113456 E002 5.4907986 0.0133620811 1.461077e-06 3.953813e-05 5 34897070 34897102 33 - 0.483 1.136 2.635
ENSG00000113456 E003 9.2710497 0.0038488572 7.526117e-13 7.879826e-11 5 34897103 34897154 52 - 0.586 1.370 2.973
ENSG00000113456 E004 8.2655429 0.0042434804 1.108259e-12 1.123629e-10 5 34897155 34897159 5 - 0.511 1.330 3.184
ENSG00000113456 E005 30.9688619 0.0177614629 1.320512e-11 1.114025e-09 5 34897160 34897381 222 - 1.184 1.791 2.088
ENSG00000113456 E006 1.7449529 0.0116335351 8.012022e-02 2.450518e-01 5 34900351 34900468 118 - 0.305 0.608 1.584
ENSG00000113456 E007 1.2153233 0.0847217513 9.802015e-01   5 34900469 34900493 25 - 0.307 0.307 0.003
ENSG00000113456 E008 4.4308058 0.0062376687 2.294337e-02 1.057580e-01 5 34900599 34900704 106 - 0.785 0.403 -1.737
ENSG00000113456 E009 3.9591667 0.0062326797 1.430566e-01 3.520759e-01 5 34900705 34900762 58 - 0.723 0.483 -1.070
ENSG00000113456 E010 290.0130946 0.0016721216 2.147680e-26 1.262026e-23 5 34905260 34908171 2912 - 2.495 2.172 -1.075
ENSG00000113456 E011 68.9964225 0.0006848248 3.098036e-06 7.641508e-05 5 34908172 34908553 382 - 1.860 1.627 -0.789
ENSG00000113456 E012 83.8349769 0.0008097635 3.827587e-05 6.638875e-04 5 34908554 34908654 101 - 1.934 1.749 -0.624
ENSG00000113456 E013 102.3513079 0.0024914833 2.514071e-02 1.126539e-01 5 34908655 34908764 110 - 2.001 1.902 -0.331
ENSG00000113456 E014 127.1118654 0.0004809275 2.881900e-01 5.289236e-01 5 34908765 34908851 87 - 2.076 2.042 -0.113
ENSG00000113456 E015 116.8920492 0.0004566352 7.020382e-03 4.473966e-02 5 34908852 34908893 42 - 2.055 1.958 -0.323
ENSG00000113456 E016 138.0730353 0.0003183922 6.217423e-02 2.076888e-01 5 34908894 34908948 55 - 2.118 2.060 -0.194
ENSG00000113456 E017 153.6854071 0.0004046627 6.655485e-01 8.133726e-01 5 34909258 34909356 99 - 2.153 2.144 -0.033
ENSG00000113456 E018 114.6241149 0.0005398408 7.308024e-01 8.546729e-01 5 34911554 34911617 64 - 2.026 2.017 -0.029
ENSG00000113456 E019 178.8028908 0.0002545754 2.609489e-05 4.782552e-04 5 34911618 34911812 195 - 2.176 2.295 0.397
ENSG00000113456 E020 120.5806668 0.0003754920 6.004837e-04 6.582491e-03 5 34913470 34913578 109 - 2.006 2.126 0.401
ENSG00000113456 E021 3.5492023 0.0118425964 2.737552e-02 1.194162e-01 5 34913871 34913926 56 - 0.706 0.305 -2.002
ENSG00000113456 E022 6.1933678 0.1399535566 8.893852e-01 9.463903e-01 5 34913927 34913969 43 - 0.831 0.786 -0.177
ENSG00000113456 E023 7.4729952 0.0975242463 5.974256e-01 7.686107e-01 5 34913970 34914026 57 - 0.916 0.791 -0.483
ENSG00000113456 E024 2.2933317 0.1282992718 8.771000e-02 2.594789e-01 5 34914477 34914694 218 - 0.568 0.178 -2.414
ENSG00000113456 E025 289.7785497 0.0005056216 1.244887e-09 7.144659e-08 5 34914695 34914961 267 - 2.379 2.517 0.461
ENSG00000113456 E026 139.9539970 0.0077583587 1.313902e-03 1.226330e-02 5 34915416 34915626 211 - 2.054 2.220 0.555
ENSG00000113456 E027 7.5478590 0.1474529793 9.408702e-01 9.726873e-01 5 34915627 34916769 1143 - 0.886 0.893 0.027
ENSG00000113456 E028 2.3338271 0.0308094250 3.983748e-02 1.543025e-01 5 34918052 34918136 85 - 0.348 0.706 1.735
ENSG00000113456 E029 1.3439786 0.0133199579 5.989675e-01   5 34918232 34918297 66 - 0.306 0.403 0.585
ENSG00000113456 E030 0.0000000       5 34918522 34918989 468 -