ENSG00000113441

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000231368 ENSG00000113441 HEK293_OSMI2_6hA HEK293_TMG_6hB LNPEP protein_coding protein_coding 2.590964 1.341321 4.734486 0.1290104 0.08899971 1.811881 1.9995098 0.8532416 4.2300931 0.17251732 0.03503495 2.2962597 0.6476667 0.6227333 0.89433333 0.2716 0.028834466 0.001599945 FALSE TRUE
ENST00000395784 ENSG00000113441 HEK293_OSMI2_6hA HEK293_TMG_6hB LNPEP protein_coding processed_transcript 2.590964 1.341321 4.734486 0.1290104 0.08899971 1.811881 0.4170576 0.4880796 0.3690622 0.05701368 0.05709470 -0.3939419 0.2521625 0.3772667 0.07806667 -0.2992 0.001599945 0.001599945 FALSE TRUE
MSTRG.26628.3 ENSG00000113441 HEK293_OSMI2_6hA HEK293_TMG_6hB LNPEP protein_coding   2.590964 1.341321 4.734486 0.1290104 0.08899971 1.811881 0.1670395 0.0000000 0.1353306 0.00000000 0.13533062 3.8612668 0.0983250 0.0000000 0.02760000 0.0276 1.000000000 0.001599945 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000113441 E001 4.6635328 0.124836116 2.268581e-03 0.0188500460 5 96935394 96935695 302 + 0.419 1.169 3.080
ENSG00000113441 E002 3.5469351 0.007705224 5.764526e-04 0.0063667347 5 96935994 96936079 86 + 0.355 1.037 2.966
ENSG00000113441 E003 2.0313198 0.010864776 2.536243e-02 0.1133244814 5 96936080 96936094 15 + 0.245 0.774 2.705
ENSG00000113441 E004 10.5461757 0.003668202 3.230077e-01 0.5623239139 5 96936095 96936174 80 + 0.857 1.176 1.175
ENSG00000113441 E005 18.8676762 0.095545893 1.246067e-05 0.0002538214 5 96936175 96937766 1592 + 0.829 1.770 3.331
ENSG00000113441 E006 0.0000000       5 96958451 96958776 326 +      
ENSG00000113441 E007 14.8498558 0.060822190 7.075660e-02 0.2262355808 5 96979138 96979293 156 + 1.061 0.995 -0.241
ENSG00000113441 E008 45.4630830 0.033297217 4.871891e-02 0.1766313939 5 96979294 96979959 666 + 1.507 1.519 0.041
ENSG00000113441 E009 11.2709432 0.005049392 6.397991e-01 0.7967953564 5 96979960 96979978 19 + 0.921 1.068 0.545
ENSG00000113441 E010 22.7996939 0.013008907 2.652366e-01 0.5045891060 5 96985080 96985218 139 + 1.208 1.315 0.375
ENSG00000113441 E011 24.2091615 0.016655397 4.509101e-03 0.0319806524 5 96986539 96986670 132 + 1.258 1.151 -0.378
ENSG00000113441 E012 21.2555693 0.024064900 2.842924e-03 0.0224617999 5 96993015 96993135 121 + 1.210 1.038 -0.620
ENSG00000113441 E013 22.0819923 0.035972053 3.782238e-03 0.0279241383 5 96993817 96993971 155 + 1.228 1.037 -0.683
ENSG00000113441 E014 0.0000000       5 96996013 96996377 365 +      
ENSG00000113441 E015 0.1426347 0.031604382 1.000000e+00   5 96996378 96996389 12 + 0.052 0.000 -16.531
ENSG00000113441 E016 14.7051097 0.016829340 4.615413e-02 0.1703957147 5 96996390 96996503 114 + 1.051 1.002 -0.180
ENSG00000113441 E017 16.2300928 0.020376987 4.020790e-02 0.1552255484 5 96998014 96998145 132 + 1.089 1.037 -0.191
ENSG00000113441 E018 20.3429249 0.008758500 1.561342e-03 0.0140497224 5 97003415 97003546 132 + 1.192 1.036 -0.560
ENSG00000113441 E019 29.5254129 0.040422792 6.035183e-05 0.0009784371 5 97006073 97006233 161 + 1.359 1.006 -1.259
ENSG00000113441 E020 0.0000000       5 97006234 97006382 149 +      
ENSG00000113441 E021 22.0960436 0.032529279 1.178940e-05 0.0002414801 5 97006427 97006515 89 + 1.247 0.775 -1.747
ENSG00000113441 E022 31.3352147 0.044814641 5.027004e-03 0.0347782170 5 97013648 97013831 184 + 1.370 1.217 -0.534
ENSG00000113441 E023 25.0140404 0.141021758 6.978652e-02 0.2243810260 5 97014939 97015095 157 + 1.274 1.174 -0.354
ENSG00000113441 E024 30.6533268 0.002354326 8.255248e-05 0.0012754103 5 97022300 97022484 185 + 1.364 1.221 -0.502
ENSG00000113441 E025 28.5546061 0.013944298 5.827267e-04 0.0064264175 5 97024521 97024682 162 + 1.330 1.177 -0.538
ENSG00000113441 E026 25.3037178 0.024306736 9.742959e-03 0.0570170783 5 97026617 97026757 141 + 1.273 1.179 -0.331
ENSG00000113441 E027 20.1798073 0.013493587 7.363351e-02 0.2320233116 5 97027733 97027814 82 + 1.167 1.177 0.037
ENSG00000113441 E028 429.2975463 0.138108570 2.354651e-02 0.1076956247 5 97028402 97037513 9112 + 2.387 2.794 1.355