ENSG00000113369

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265138 ENSG00000113369 HEK293_OSMI2_6hA HEK293_TMG_6hB ARRDC3 protein_coding protein_coding 2.753212 0.571636 7.226051 0.2356743 0.1555445 3.637014 1.94732955 0.39734267 4.59440052 0.12180371 0.03222728 3.4986985 0.80481250 0.75073333 0.6365333 -0.11420000 0.831830924 0.009343151 FALSE TRUE
ENST00000508948 ENSG00000113369 HEK293_OSMI2_6hA HEK293_TMG_6hB ARRDC3 protein_coding processed_transcript 2.753212 0.571636 7.226051 0.2356743 0.1555445 3.637014 0.02508162 0.06245168 0.05061931 0.06245168 0.05061931 -0.2572417 0.02853333 0.06063333 0.0070000 -0.05363333 0.601626218 0.009343151   FALSE
ENST00000511391 ENSG00000113369 HEK293_OSMI2_6hA HEK293_TMG_6hB ARRDC3 protein_coding retained_intron 2.753212 0.571636 7.226051 0.2356743 0.1555445 3.637014 0.44858108 0.00000000 1.41866877 0.00000000 0.24889179 7.1585277 0.08472083 0.00000000 0.1961667 0.19616667 0.009343151 0.009343151   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000113369 E001 141.3438123 0.0004424233 0.001565132 0.01407517 5 91368631 91370797 2167 - 1.897 2.013 0.387
ENSG00000113369 E002 58.1527134 0.0012253916 0.192690896 0.42037082 5 91370798 91371456 659 - 1.542 1.436 -0.365
ENSG00000113369 E003 27.6808597 0.0037860236 0.735674711 0.85772665 5 91373684 91373838 155 - 1.221 1.251 0.108
ENSG00000113369 E004 3.3498487 0.0072132867 0.523074715 0.71712374 5 91373839 91373845 7 - 0.474 0.312 -0.910
ENSG00000113369 E005 20.4282843 0.0019542887 0.472706480 0.68197323 5 91374114 91374224 111 - 1.086 1.167 0.290
ENSG00000113369 E006 10.5303269 0.0032517625 0.524664846 0.71824176 5 91374225 91374276 52 - 0.829 0.923 0.360
ENSG00000113369 E007 10.8199883 0.0038024280 0.198834176 0.42821691 5 91374922 91374999 78 - 0.865 0.619 -1.003
ENSG00000113369 E008 22.9309713 0.0055871582 0.538137554 0.72773968 5 91375000 91375178 179 - 1.146 1.061 -0.306
ENSG00000113369 E009 0.0000000       5 91375179 91375344 166 -      
ENSG00000113369 E010 11.0549303 0.0315605367 0.020013896 0.09593598 5 91375511 91375520 10 - 0.882 0.313 -2.649
ENSG00000113369 E011 11.4850471 0.0156529994 0.012205040 0.06726477 5 91375521 91375526 6 - 0.896 0.312 -2.706
ENSG00000113369 E012 18.9951990 0.0222565725 0.107565893 0.29499326 5 91375527 91375613 87 - 1.083 0.797 -1.077
ENSG00000113369 E013 0.0000000       5 91376559 91376620 62 -      
ENSG00000113369 E014 15.7637399 0.0021768331 0.351650790 0.58875878 5 91376621 91376768 148 - 1.009 0.864 -0.544
ENSG00000113369 E015 13.0971142 0.0027455384 0.276052779 0.51609203 5 91378694 91378775 82 - 0.915 1.061 0.542
ENSG00000113369 E016 1.9085478 0.0108759229 0.365387946 0.60025693 5 91379882 91379922 41 - 0.299 0.492 1.088
ENSG00000113369 E017 3.3428838 0.0071959517 0.387077656 0.61820804 5 91379923 91380151 229 - 0.444 0.618 0.824
ENSG00000113369 E018 0.4536995 0.1842030076 0.202847859   5 91380780 91381020 241 - 0.079 0.309 2.389
ENSG00000113369 E019 17.6876927 0.0065452316 0.210625482 0.44256030 5 91382813 91383317 505 - 1.059 0.864 -0.730