ENSG00000113368

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261366 ENSG00000113368 HEK293_OSMI2_6hA HEK293_TMG_6hB LMNB1 protein_coding protein_coding 111.6824 77.67656 150.7685 14.60082 2.847148 0.9566943 45.623353 34.010700 42.831526 7.212725 1.0150527 0.3325971 0.40361667 0.43530000 0.28436667 -0.15093333 3.057792e-02 8.407131e-40 FALSE TRUE
ENST00000463908 ENSG00000113368 HEK293_OSMI2_6hA HEK293_TMG_6hB LMNB1 protein_coding processed_transcript 111.6824 77.67656 150.7685 14.60082 2.847148 0.9566943 3.392043 1.107604 14.279712 1.107604 2.2534049 3.6764960 0.02612083 0.02276667 0.09490000 0.07213333 2.000489e-01 8.407131e-40   FALSE
ENST00000472034 ENSG00000113368 HEK293_OSMI2_6hA HEK293_TMG_6hB LMNB1 protein_coding processed_transcript 111.6824 77.67656 150.7685 14.60082 2.847148 0.9566943 10.459705 0.000000 14.518886 0.000000 0.8605449 10.5047084 0.07169167 0.00000000 0.09616667 0.09616667 8.407131e-40 8.407131e-40 FALSE FALSE
ENST00000494185 ENSG00000113368 HEK293_OSMI2_6hA HEK293_TMG_6hB LMNB1 protein_coding retained_intron 111.6824 77.67656 150.7685 14.60082 2.847148 0.9566943 4.654326 0.000000 9.733841 0.000000 0.3587220 9.9283468 0.03103333 0.00000000 0.06460000 0.06460000 2.232770e-34 8.407131e-40 FALSE FALSE
ENST00000504788 ENSG00000113368 HEK293_OSMI2_6hA HEK293_TMG_6hB LMNB1 protein_coding processed_transcript 111.6824 77.67656 150.7685 14.60082 2.847148 0.9566943 29.051287 12.897245 33.422400 5.981085 16.6223394 1.3730658 0.27797500 0.18913333 0.21783333 0.02870000 1.000000e+00 8.407131e-40 FALSE TRUE
MSTRG.26852.7 ENSG00000113368 HEK293_OSMI2_6hA HEK293_TMG_6hB LMNB1 protein_coding   111.6824 77.67656 150.7685 14.60082 2.847148 0.9566943 18.040757 29.436514 35.394883 13.449834 13.6536213 0.2658515 0.18562500 0.35000000 0.23816667 -0.11183333 8.168352e-01 8.407131e-40 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000113368 E001 0.0000000       5 126776375 126776416 42 +      
ENSG00000113368 E002 0.0000000       5 126776417 126776622 206 +      
ENSG00000113368 E003 4.4080423 6.070387e-03 9.354588e-01 9.698784e-01 5 126776623 126777135 513 + 0.738 0.737 -0.002
ENSG00000113368 E004 10.6510307 3.757246e-02 6.991165e-01 8.350575e-01 5 126777136 126777152 17 + 1.087 1.039 -0.175
ENSG00000113368 E005 34.0230172 1.976975e-02 8.559472e-02 2.556806e-01 5 126777153 126777160 8 + 1.604 1.455 -0.509
ENSG00000113368 E006 83.0227935 1.253066e-03 1.348632e-01 3.394829e-01 5 126777161 126777188 28 + 1.945 1.894 -0.171
ENSG00000113368 E007 155.4951885 9.091878e-04 9.871073e-02 2.795544e-01 5 126777189 126777244 56 + 2.209 2.168 -0.138
ENSG00000113368 E008 138.6206290 3.187382e-04 5.344373e-01 7.252214e-01 5 126777245 126777252 8 + 2.146 2.139 -0.023
ENSG00000113368 E009 241.9451896 3.276002e-04 6.388387e-01 7.961948e-01 5 126777253 126777360 108 + 2.384 2.385 0.003
ENSG00000113368 E010 163.7436584 2.830144e-04 3.008939e-01 5.413740e-01 5 126777361 126777378 18 + 2.196 2.237 0.140
ENSG00000113368 E011 169.0389336 3.250625e-04 1.497765e-02 7.799670e-02 5 126777379 126777406 28 + 2.190 2.271 0.269
ENSG00000113368 E012 316.2316973 6.558136e-04 2.381949e-14 3.326560e-12 5 126777407 126777697 291 + 2.408 2.597 0.630
ENSG00000113368 E013 316.5850238 4.786152e-03 8.599486e-02 2.564113e-01 5 126777698 126777867 170 + 2.462 2.544 0.275
ENSG00000113368 E014 610.4800629 1.153158e-03 2.446937e-01 4.818429e-01 5 126804776 126804932 157 + 2.790 2.776 -0.045
ENSG00000113368 E015 815.8157286 1.679113e-04 7.729021e-09 3.724253e-07 5 126805571 126805696 126 + 2.936 2.871 -0.219
ENSG00000113368 E016 1097.3172163 1.036280e-04 5.962246e-06 1.341628e-04 5 126810180 126810350 171 + 3.054 3.015 -0.128
ENSG00000113368 E017 0.1614157 3.374138e-02 6.306573e-01   5 126811713 126811772 60 + 0.107 0.001 -7.818
ENSG00000113368 E018 923.5456263 9.777894e-05 1.353931e-05 2.727504e-04 5 126811773 126811898 126 + 2.980 2.940 -0.133
ENSG00000113368 E019 1.8731309 2.834608e-01 8.050198e-01 8.992066e-01 5 126815170 126815247 78 + 0.468 0.488 0.101
ENSG00000113368 E020 1174.4920452 8.399204e-05 7.293343e-06 1.595283e-04 5 126818922 126819142 221 + 3.082 3.046 -0.118
ENSG00000113368 E021 1.6895351 1.343226e-02 3.939722e-01 6.235024e-01 5 126819143 126819234 92 + 0.471 0.326 -0.806
ENSG00000113368 E022 1137.8595737 7.540190e-04 1.094288e-01 2.981626e-01 5 126820910 126821135 226 + 3.059 3.043 -0.052
ENSG00000113368 E023 791.9259299 3.364045e-04 6.288926e-01 7.897483e-01 5 126822781 126822885 105 + 2.888 2.906 0.061
ENSG00000113368 E024 747.7182834 9.534324e-05 1.017771e-02 5.887954e-02 5 126825988 126826107 120 + 2.850 2.897 0.155
ENSG00000113368 E025 684.6610067 1.106487e-04 5.242820e-03 3.590127e-02 5 126832694 126832801 108 + 2.809 2.861 0.171
ENSG00000113368 E026 1703.9460115 2.895505e-03 1.808245e-03 1.575585e-02 5 126836223 126837020 798 + 3.185 3.277 0.306