ENSG00000113328

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340828 ENSG00000113328 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNG1 protein_coding protein_coding 74.86958 22.42704 140.1114 5.135147 7.495358 2.642723 54.720381 15.565342 110.2938 5.075853 2.618355 2.824147 0.6772458 0.6643667 0.7898667 0.1255000 7.106472e-01 4.02538e-10 FALSE TRUE
ENST00000509425 ENSG00000113328 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNG1 protein_coding processed_transcript 74.86958 22.42704 140.1114 5.135147 7.495358 2.642723 5.615461 3.003609 0.0000 1.806448 0.000000 -8.235348 0.1537458 0.1284667 0.0000000 -0.1284667 4.025380e-10 4.02538e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000113328 E001 0.3228314 0.3883366237 1.000000e+00   5 163437569 163437570 2 + 0.105 0.000 -8.365
ENSG00000113328 E002 0.8214337 0.0175653620 5.002920e-01   5 163437571 163437582 12 + 0.227 0.000 -11.876
ENSG00000113328 E003 3.2236647 0.0150258334 4.307254e-01 6.516909e-01 5 163437583 163437594 12 + 0.556 0.401 -0.773
ENSG00000113328 E004 17.0930899 0.0022855105 4.327351e-01 6.532861e-01 5 163437595 163437606 12 + 1.120 1.209 0.320
ENSG00000113328 E005 51.4964238 0.0007089433 9.210954e-01 9.627858e-01 5 163437607 163437613 7 + 1.585 1.599 0.048
ENSG00000113328 E006 169.3310832 0.0008295433 3.622645e-01 5.975395e-01 5 163437614 163437664 51 + 2.091 2.135 0.148
ENSG00000113328 E007 169.6726254 0.0006025013 3.449974e-01 5.825643e-01 5 163437665 163437668 4 + 2.092 2.136 0.148
ENSG00000113328 E008 160.1256303 0.0007958155 2.004461e-01 4.302697e-01 5 163437669 163437669 1 + 2.065 2.123 0.196
ENSG00000113328 E009 269.1208266 0.0002818623 4.925228e-01 6.956915e-01 5 163437670 163437750 81 + 2.297 2.284 -0.044
ENSG00000113328 E010 172.2855237 0.0002671641 6.077034e-01 7.753434e-01 5 163437751 163437764 14 + 2.105 2.094 -0.039
ENSG00000113328 E011 158.0771179 0.0002839621 6.270314e-01 7.885627e-01 5 163437765 163437765 1 + 2.069 2.058 -0.037
ENSG00000113328 E012 161.7083938 0.0002687520 6.689249e-01 8.155117e-01 5 163437766 163437768 3 + 2.078 2.069 -0.029
ENSG00000113328 E013 220.4128467 0.0002478340 6.369601e-01 7.950320e-01 5 163437769 163437793 25 + 2.206 2.230 0.077
ENSG00000113328 E014 197.7567803 0.0011302927 8.734100e-01 9.378450e-01 5 163437794 163437804 11 + 2.162 2.165 0.010
ENSG00000113328 E015 2.6006180 0.3250089211 4.923414e-02 1.777556e-01 5 163439191 163439256 66 + 0.318 0.860 2.535
ENSG00000113328 E016 393.0558403 0.0003169926 2.789521e-02 1.209866e-01 5 163439257 163439346 90 + 2.467 2.417 -0.165
ENSG00000113328 E017 547.5986433 0.0001637002 3.480574e-06 8.447641e-05 5 163439347 163439520 174 + 2.617 2.523 -0.312
ENSG00000113328 E018 2.2606710 0.0677835591 5.395988e-03 3.667784e-02 5 163439521 163439602 82 + 0.292 0.802 2.480
ENSG00000113328 E019 416.7030668 0.0002139969 7.291419e-01 8.537069e-01 5 163441078 163441177 100 + 2.486 2.485 -0.003
ENSG00000113328 E020 324.3075347 0.0001889851 8.819076e-01 9.423349e-01 5 163441178 163441210 33 + 2.375 2.378 0.009
ENSG00000113328 E021 529.1354600 0.0005214537 6.715757e-01 8.172802e-01 5 163441211 163441331 121 + 2.589 2.584 -0.017
ENSG00000113328 E022 3.7442359 0.0807688908 3.722112e-01 6.057675e-01 5 163441656 163441885 230 + 0.593 0.399 -0.955
ENSG00000113328 E023 425.0566443 0.0015971237 4.069584e-03 2.956630e-02 5 163441886 163441964 79 + 2.505 2.419 -0.287
ENSG00000113328 E024 473.4444438 0.0017922554 1.726006e-01 3.939354e-01 5 163442045 163442143 99 + 2.545 2.504 -0.136
ENSG00000113328 E025 775.4265264 0.0001187209 2.050767e-01 4.360100e-01 5 163442374 163442568 195 + 2.756 2.740 -0.052
ENSG00000113328 E026 539.1515491 0.0008023067 1.285987e-01 3.296456e-01 5 163443674 163443756 83 + 2.588 2.628 0.132
ENSG00000113328 E027 446.2354596 0.0006728688 2.865240e-01 5.272048e-01 5 163443757 163443795 39 + 2.508 2.538 0.101
ENSG00000113328 E028 616.4662123 0.0001755926 8.704635e-01 9.361793e-01 5 163443796 163443925 130 + 2.654 2.658 0.013
ENSG00000113328 E029 834.2786011 0.0059521168 7.009701e-01 8.362317e-01 5 163443926 163444336 411 + 2.786 2.766 -0.066
ENSG00000113328 E030 449.5646309 0.0046130258 1.105902e-02 6.261716e-02 5 163444337 163444481 145 + 2.499 2.596 0.325
ENSG00000113328 E031 965.2899939 0.0014677554 3.146473e-04 3.877674e-03 5 163444482 163445016 535 + 2.834 2.914 0.267
ENSG00000113328 E032 0.8993890 0.0167418687 5.546989e-03   5 163445904 163445981 78 + 0.105 0.606 3.472
ENSG00000113328 E033 0.6482515 0.0264989980 6.106480e-01   5 163445982 163446151 170 + 0.150 0.245 0.884
ENSG00000113328 E034 0.1426347 0.0328073474 1.000000e+00   5 163446676 163446723 48 + 0.056 0.000 -9.616