ENSG00000113163

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380494 ENSG00000113163 HEK293_OSMI2_6hA HEK293_TMG_6hB CERT1 protein_coding protein_coding 10.4404 3.752683 19.56539 0.656964 0.693299 2.379208 4.0088910 2.0018687 6.8012589 0.41364363 0.29749001 1.759385 0.45384583 0.52780000 0.3476000 -0.180200000 0.03207931 0.03207931 FALSE TRUE
ENST00000642556 ENSG00000113163 HEK293_OSMI2_6hA HEK293_TMG_6hB CERT1 protein_coding protein_coding 10.4404 3.752683 19.56539 0.656964 0.693299 2.379208 1.5307202 0.6103657 3.2088077 0.12227197 0.58735055 2.375335 0.12728750 0.16553333 0.1633333 -0.002200000 1.00000000 0.03207931 FALSE TRUE
ENST00000643780 ENSG00000113163 HEK293_OSMI2_6hA HEK293_TMG_6hB CERT1 protein_coding protein_coding 10.4404 3.752683 19.56539 0.656964 0.693299 2.379208 0.5557141 0.2248396 0.9900845 0.04084671 0.09218872 2.090374 0.06907917 0.06033333 0.0509000 -0.009433333 0.92294872 0.03207931 FALSE TRUE
ENST00000644445 ENSG00000113163 HEK293_OSMI2_6hA HEK293_TMG_6hB CERT1 protein_coding protein_coding 10.4404 3.752683 19.56539 0.656964 0.693299 2.379208 1.8711103 0.5995904 4.4858984 0.18638484 0.24194239 2.882697 0.16142917 0.15063333 0.2306667 0.080033333 0.51454953 0.03207931 FALSE TRUE
ENST00000645483 ENSG00000113163 HEK293_OSMI2_6hA HEK293_TMG_6hB CERT1 protein_coding protein_coding 10.4404 3.752683 19.56539 0.656964 0.693299 2.379208 0.7595919 0.0000000 1.5194979 0.00000000 0.79784414 7.256914 0.04228333 0.00000000 0.0753000 0.075300000 0.51576825 0.03207931 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000113163 E001 0.0000000       5 75356345 75356351 7 -      
ENSG00000113163 E002 1.1106968 0.0979569721 2.180522e-01   5 75356352 75357012 661 - 0.217 0.466 1.569
ENSG00000113163 E003 0.3503582 0.0454421291 3.141400e-01   5 75368486 75368486 1 - 0.065 0.217 2.008
ENSG00000113163 E004 0.3503582 0.0454421291 3.141400e-01   5 75368487 75368487 1 - 0.065 0.217 2.008
ENSG00000113163 E005 1.8816706 0.0665943328 7.571647e-02 2.362199e-01 5 75368488 75368517 30 - 0.293 0.633 1.775
ENSG00000113163 E006 5.1719313 0.0070471117 7.082168e-03 4.499664e-02 5 75368518 75368658 141 - 0.590 0.975 1.543
ENSG00000113163 E007 4.3707922 0.0071105277 7.885131e-01 8.896396e-01 5 75368659 75369236 578 - 0.641 0.689 0.205
ENSG00000113163 E008 13.4347741 0.0025649280 1.219469e-02 6.723392e-02 5 75369237 75371119 1883 - 1.007 1.266 0.930
ENSG00000113163 E009 3.7721072 0.0073456377 4.195838e-02 1.598311e-01 5 75371120 75371120 1 - 0.512 0.834 1.371
ENSG00000113163 E010 178.8429923 0.0034147392 1.690466e-09 9.452749e-08 5 75371121 75372330 1210 - 2.100 2.334 0.783
ENSG00000113163 E011 17.3422269 0.0022022144 5.796926e-03 3.872895e-02 5 75372331 75372418 88 - 1.105 1.362 0.907
ENSG00000113163 E012 16.7941238 0.0021485908 1.257937e-02 6.875552e-02 5 75372419 75372430 12 - 1.100 1.337 0.839
ENSG00000113163 E013 39.7980071 0.0013347016 2.917041e-03 2.290142e-02 5 75372431 75372597 167 - 1.469 1.666 0.671
ENSG00000113163 E014 174.8372607 0.0003151619 4.317504e-04 5.047232e-03 5 75372598 75373269 672 - 2.124 2.240 0.388
ENSG00000113163 E015 48.5868626 0.0013787733 4.440200e-03 3.160699e-02 5 75373270 75373362 93 - 1.559 1.733 0.593
ENSG00000113163 E016 109.9925375 0.0039934003 4.350285e-01 6.549861e-01 5 75373363 75373962 600 - 1.943 1.984 0.137
ENSG00000113163 E017 49.9877414 0.0007911464 8.440854e-01 9.216261e-01 5 75373963 75374154 192 - 1.618 1.614 -0.015
ENSG00000113163 E018 21.2188306 0.0097094051 2.245526e-01 4.588677e-01 5 75374155 75374155 1 - 1.280 1.162 -0.416
ENSG00000113163 E019 32.3383053 0.0015417854 7.290145e-01 8.536155e-01 5 75374156 75374191 36 - 1.437 1.419 -0.064
ENSG00000113163 E020 12.7881855 0.0043253451 1.678378e-01 3.877229e-01 5 75377775 75378517 743 - 1.008 1.164 0.568
ENSG00000113163 E021 11.4359750 0.0035723686 9.760803e-01 9.898300e-01 5 75378518 75379336 819 - 1.000 1.003 0.010
ENSG00000113163 E022 26.8244612 0.0012458247 5.659279e-01 7.473314e-01 5 75379337 75379354 18 - 1.344 1.397 0.184
ENSG00000113163 E023 34.8254300 0.0010656838 2.061664e-01 4.372266e-01 5 75379355 75379399 45 - 1.445 1.540 0.325
ENSG00000113163 E024 25.2289519 0.0014725503 1.916955e-01 4.190228e-01 5 75379400 75379418 19 - 1.307 1.419 0.387
ENSG00000113163 E025 42.8555078 0.0015279716 3.449112e-02 1.401825e-01 5 75379419 75379459 41 - 1.518 1.659 0.480
ENSG00000113163 E026 38.7884129 0.0101343512 3.567162e-01 5.931056e-01 5 75379460 75379473 14 - 1.490 1.577 0.301
ENSG00000113163 E027 59.2127301 0.0008489081 9.616318e-01 9.828370e-01 5 75381072 75381144 73 - 1.684 1.695 0.037
ENSG00000113163 E028 54.9947090 0.0006423946 1.560410e-01 3.709634e-01 5 75381145 75381201 57 - 1.671 1.593 -0.264
ENSG00000113163 E029 72.6397772 0.0005587725 2.637751e-02 1.164053e-01 5 75381949 75382077 129 - 1.794 1.683 -0.375
ENSG00000113163 E030 49.9044684 0.0007805555 8.072554e-02 2.462911e-01 5 75384642 75384712 71 - 1.635 1.531 -0.353
ENSG00000113163 E031 45.6634719 0.0015135901 2.284546e-01 4.634285e-01 5 75385902 75385947 46 - 1.594 1.523 -0.244
ENSG00000113163 E032 58.0111542 0.0087869711 7.956890e-01 8.938521e-01 5 75385948 75386034 87 - 1.684 1.679 -0.018
ENSG00000113163 E033 0.0000000       5 75386035 75386057 23 -      
ENSG00000113163 E034 71.5779609 0.0008024074 5.242480e-02 1.853041e-01 5 75389592 75389687 96 - 1.790 1.694 -0.323
ENSG00000113163 E035 20.0604351 0.0020197131 1.309989e-01 3.333728e-01 5 75399310 75399387 78 - 1.264 1.123 -0.500
ENSG00000113163 E036 68.2409926 0.0005768377 5.322988e-02 1.873038e-01 5 75400205 75400291 87 - 1.769 1.671 -0.330
ENSG00000113163 E037 35.7830739 0.0011150928 5.502012e-01 7.364131e-01 5 75400292 75400297 6 - 1.485 1.450 -0.123
ENSG00000113163 E038 0.8102147 0.3165978475 3.819464e-01   5 75400298 75402674 2377 - 0.170 0.364 1.452
ENSG00000113163 E039 0.0000000       5 75402675 75402792 118 -      
ENSG00000113163 E040 0.0000000       5 75402793 75402971 179 -      
ENSG00000113163 E041 63.2368017 0.0038826156 4.158741e-01 6.404446e-01 5 75402972 75403058 87 - 1.728 1.682 -0.154
ENSG00000113163 E042 0.7695163 0.0583885248 3.139278e-01   5 75410690 75411010 321 - 0.256 0.000 -11.922
ENSG00000113163 E043 64.7175673 0.0006456540 6.146100e-02 2.060551e-01 5 75411011 75411103 93 - 1.744 1.647 -0.331
ENSG00000113163 E044 85.8721670 0.0004607194 2.735972e-04 3.463562e-03 5 75416876 75417010 135 - 1.877 1.700 -0.596
ENSG00000113163 E045 52.4149779 0.0006955103 4.076270e-03 2.959827e-02 5 75417011 75417033 23 - 1.666 1.488 -0.608
ENSG00000113163 E046 64.5034083 0.0006240056 7.697511e-04 8.025136e-03 5 75419341 75419424 84 - 1.754 1.563 -0.649
ENSG00000113163 E047 0.0000000       5 75425270 75425291 22 -      
ENSG00000113163 E048 0.1779838 0.0364512199 1.000000e+00   5 75425292 75425360 69 - 0.065 0.000 -9.750
ENSG00000113163 E049 91.1723443 0.0004426800 1.188007e-04 1.724367e-03 5 75425361 75425494 134 - 1.904 1.722 -0.613
ENSG00000113163 E050 45.5119990 0.0041026149 2.448789e-03 2.000100e-02 5 75425495 75425499 5 - 1.615 1.395 -0.756
ENSG00000113163 E051 68.1355449 0.0062515257 3.967728e-02 1.538975e-01 5 75426371 75426478 108 - 1.774 1.649 -0.421
ENSG00000113163 E052 61.5585359 0.0006350680 1.956066e-01 4.241056e-01 5 75459065 75459181 117 - 1.718 1.653 -0.222
ENSG00000113163 E053 0.1308682 0.0326491905 1.069089e-01   5 75505230 75505981 752 - 0.000 0.216 11.949
ENSG00000113163 E054 59.7934999 0.0007977464 1.298508e-01 3.316047e-01 5 75505982 75506116 135 - 1.708 1.627 -0.273
ENSG00000113163 E055 51.9787297 0.0010883854 5.962565e-01 7.678337e-01 5 75511112 75511428 317 - 1.638 1.614 -0.083
ENSG00000113163 E056 27.4656576 0.0054501191 7.017443e-01 8.366868e-01 5 75511429 75511505 77 - 1.357 1.396 0.136
ENSG00000113163 E057 22.8541729 0.0204846137 6.833830e-01 8.248516e-01 5 75511506 75511638 133 - 1.279 1.322 0.150
ENSG00000113163 E058 0.4842470 0.7758091881 1.000000e+00   5 75511759 75512138 380 - 0.172 0.000 -10.098