ENSG00000113048

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261413 ENSG00000113048 HEK293_OSMI2_6hA HEK293_TMG_6hB MRPS27 protein_coding protein_coding 59.79733 41.85172 66.87324 10.40822 2.595029 0.6760132 13.653306 9.7946741 17.870676 2.8719378 1.52739115 0.8668597 0.22768333 0.22710000 0.2664000 0.039300000 6.971431e-01 7.770638e-15 FALSE TRUE
ENST00000457646 ENSG00000113048 HEK293_OSMI2_6hA HEK293_TMG_6hB MRPS27 protein_coding protein_coding 59.79733 41.85172 66.87324 10.40822 2.595029 0.6760132 3.516228 2.0789695 3.684436 0.9220879 0.43366305 0.8225628 0.05762083 0.04533333 0.0549000 0.009566667 8.466493e-01 7.770638e-15 FALSE TRUE
ENST00000694998 ENSG00000113048 HEK293_OSMI2_6hA HEK293_TMG_6hB MRPS27 protein_coding nonsense_mediated_decay 59.79733 41.85172 66.87324 10.40822 2.595029 0.6760132 1.394242 2.4080992 0.000000 0.9966101 0.00000000 -7.9177296 0.02349583 0.05533333 0.0000000 -0.055333333 7.770638e-15 7.770638e-15 FALSE TRUE
ENST00000695298 ENSG00000113048 HEK293_OSMI2_6hA HEK293_TMG_6hB MRPS27 protein_coding protein_coding 59.79733 41.85172 66.87324 10.40822 2.595029 0.6760132 33.558101 23.2702200 32.134410 5.8596479 1.91600376 0.4654632 0.55800000 0.55436667 0.4799667 -0.074400000 2.693496e-01 7.770638e-15 FALSE TRUE
MSTRG.26365.28 ENSG00000113048 HEK293_OSMI2_6hA HEK293_TMG_6hB MRPS27 protein_coding   59.79733 41.85172 66.87324 10.40822 2.595029 0.6760132 3.269149 0.8544682 5.986493 0.4881081 0.09683247 2.7942342 0.05580417 0.02556667 0.0899000 0.064333333 5.693481e-01 7.770638e-15 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000113048 E001 1.5736761 0.0398468314 0.6172787279 0.781943484 5 72205040 72206632 1593 - 0.328 0.457 0.729
ENSG00000113048 E002 0.7282998 0.3411536865 0.9135139991   5 72206633 72207021 389 - 0.194 0.249 0.457
ENSG00000113048 E003 0.6847684 0.0193874923 0.3809181459   5 72214953 72215026 74 - 0.265 0.137 -1.183
ENSG00000113048 E004 14.6883567 0.0064157671 0.3996226274 0.627971507 5 72215027 72216084 1058 - 1.117 1.258 0.501
ENSG00000113048 E005 4.5912891 0.0289070440 0.4974294032 0.699135996 5 72216085 72216137 53 - 0.668 0.818 0.609
ENSG00000113048 E006 3.8214830 0.0236975461 0.5005127934 0.701105985 5 72216138 72216174 37 - 0.612 0.764 0.635
ENSG00000113048 E007 62.3957761 0.0442627563 0.1302178042 0.332151434 5 72216175 72218041 1867 - 1.671 1.920 0.839
ENSG00000113048 E008 40.5370305 0.0794535567 0.5258357140 0.719138300 5 72218042 72219365 1324 - 1.531 1.704 0.589
ENSG00000113048 E009 3.9460221 0.5196473913 0.8482845905 0.923971433 5 72219366 72219402 37 - 0.700 0.685 -0.064
ENSG00000113048 E010 2.8881002 0.3520425646 0.9933222051 0.998324911 5 72219403 72219408 6 - 0.573 0.607 0.153
ENSG00000113048 E011 4.5006625 0.1814954349 0.9948911940 0.999014955 5 72219409 72219421 13 - 0.750 0.737 -0.052
ENSG00000113048 E012 12.6623587 0.1975642882 0.5751895879 0.753805834 5 72219422 72219525 104 - 1.101 1.174 0.262
ENSG00000113048 E013 9.6316687 0.1577156088 0.4752647819 0.683712482 5 72219526 72219527 2 - 0.964 1.092 0.472
ENSG00000113048 E014 10.8042300 0.1477666365 0.2192851265 0.452558217 5 72219528 72219528 1 - 0.951 1.186 0.855
ENSG00000113048 E015 36.3586335 0.3579862415 0.1497980470 0.361987228 5 72219529 72219545 17 - 1.402 1.719 1.083
ENSG00000113048 E016 579.1353014 1.6237681920 0.4844320909 0.690167736 5 72219546 72219939 394 - 2.645 2.874 0.763
ENSG00000113048 E017 430.5262990 1.5250186572 0.4784470314 0.686035582 5 72219940 72220048 109 - 2.518 2.744 0.751
ENSG00000113048 E018 528.0108318 1.5834571560 0.4589049618 0.672455908 5 72220049 72220327 279 - 2.594 2.842 0.825
ENSG00000113048 E019 375.0245316 1.4401371518 0.3893990869 0.619986825 5 72220328 72220550 223 - 2.414 2.715 1.003
ENSG00000113048 E020 580.2747150 1.6283295060 0.4908770219 0.694569309 5 72220551 72220852 302 - 2.651 2.871 0.732
ENSG00000113048 E021 306.3011070 1.4046923603 0.4528422734 0.667792926 5 72220853 72220938 86 - 2.369 2.598 0.761
ENSG00000113048 E022 379.7520295 1.4926404752 0.4912655109 0.694806393 5 72220939 72221088 150 - 2.479 2.678 0.662
ENSG00000113048 E023 246.1940514 1.3701907141 0.5408017820 0.729588346 5 72221089 72221148 60 - 2.328 2.458 0.433
ENSG00000113048 E024 1.7217480 0.4722138070 0.1025244829 0.286266508 5 72222449 72222527 79 - 0.558 0.141 -2.775
ENSG00000113048 E025 397.2872701 0.0002314496 0.3889535921 0.619662285 5 72223683 72223802 120 - 2.577 2.622 0.151
ENSG00000113048 E026 250.9024942 0.0138391761 0.1172185008 0.311188328 5 72223803 72223850 48 - 2.399 2.395 -0.012
ENSG00000113048 E027 42.5982589 0.0210104265 0.9603404483 0.982009048 5 72223851 72223916 66 - 1.593 1.682 0.302
ENSG00000113048 E028 451.1059048 0.0293971920 0.0777740528 0.240334670 5 72226057 72226199 143 - 2.671 2.625 -0.150
ENSG00000113048 E029 19.5929473 0.2041631486 0.0093330685 0.055233123 5 72226828 72227049 222 - 1.467 0.950 -1.841
ENSG00000113048 E030 21.2842531 0.1778767727 0.0161103466 0.082203815 5 72227050 72227275 226 - 1.479 1.054 -1.498
ENSG00000113048 E031 17.5820228 0.0924195698 0.0064307478 0.041828431 5 72227276 72227645 370 - 1.391 1.007 -1.367
ENSG00000113048 E032 7.9455298 0.0634897874 0.0201822533 0.096522313 5 72227646 72227762 117 - 1.057 0.739 -1.213
ENSG00000113048 E033 20.3370304 0.1245254192 0.0010691612 0.010445758 5 72227763 72228265 503 - 1.487 0.936 -1.960
ENSG00000113048 E034 373.1850971 0.0409687054 0.0927585176 0.268887917 5 72228266 72228368 103 - 2.595 2.533 -0.208
ENSG00000113048 E035 4.8450691 0.1935049376 0.0546312318 0.190502037 5 72228369 72229553 1185 - 0.893 0.507 -1.623
ENSG00000113048 E036 367.1337391 0.0523476519 0.0984726123 0.279110647 5 72232443 72232558 116 - 2.595 2.516 -0.266
ENSG00000113048 E037 250.5926882 0.0513835930 0.1448662990 0.354764503 5 72234119 72234197 79 - 2.421 2.364 -0.192
ENSG00000113048 E038 256.6555496 0.0407433409 0.1016290678 0.284697852 5 72238014 72238074 61 - 2.435 2.368 -0.224
ENSG00000113048 E039 269.4209878 0.0404928319 0.1106263051 0.300016771 5 72238075 72238128 54 - 2.455 2.391 -0.214
ENSG00000113048 E040 0.0000000       5 72238129 72238130 2 -      
ENSG00000113048 E041 0.0000000       5 72241462 72241646 185 -      
ENSG00000113048 E042 0.4043710 0.0728332876 0.5179064227   5 72241647 72241688 42 - 0.107 0.239 1.389
ENSG00000113048 E043 0.0000000       5 72255073 72255609 537 -      
ENSG00000113048 E044 1.1364427 0.0139658550 0.0730681804   5 72255610 72257583 1974 - 0.429 0.137 -2.185
ENSG00000113048 E045 0.8627522 0.0287314704 0.2199163599   5 72280850 72283504 2655 - 0.327 0.137 -1.599
ENSG00000113048 E046 1.1174740 0.0662946127 0.3489799506   5 72283505 72283658 154 - 0.380 0.241 -0.919
ENSG00000113048 E047 0.3040503 0.0244411696 0.2430714460   5 72288115 72288814 700 - 0.193 0.000 -11.085
ENSG00000113048 E048 0.0000000       5 72288815 72288930 116 -      
ENSG00000113048 E049 1.1336663 0.0262928013 0.0797331505   5 72290950 72292181 1232 - 0.429 0.137 -2.181
ENSG00000113048 E050 0.1779838 0.1280783604 0.5459809881   5 72294554 72294788 235 - 0.108 0.000 -10.093
ENSG00000113048 E051 0.1614157 0.0318683793 0.5470333224   5 72295315 72295530 216 - 0.108 0.000 -10.087
ENSG00000113048 E052 186.0309920 0.0285370645 0.0428531031 0.162166593 5 72295531 72295548 18 - 2.301 2.220 -0.270
ENSG00000113048 E053 223.0934551 0.0338759772 0.0400119519 0.154743679 5 72295549 72295589 41 - 2.386 2.290 -0.320
ENSG00000113048 E054 238.1639029 0.0365891101 0.0241070532 0.109387381 5 72297632 72297702 71 - 2.422 2.305 -0.391
ENSG00000113048 E055 0.1308682 0.0319719903 0.4406894492   5 72297919 72298263 345 - 0.000 0.137 10.848
ENSG00000113048 E056 0.7145081 0.0206845471 0.8953401875   5 72299589 72303872 4284 - 0.194 0.241 0.402
ENSG00000113048 E057 1.3806154 0.0133623226 0.2390295635   5 72307718 72307898 181 - 0.265 0.508 1.396
ENSG00000113048 E058 1.7854637 0.0111855589 0.0181113651 0.089402853 5 72307899 72308099 201 - 0.194 0.637 2.568
ENSG00000113048 E059 5.2667966 0.0098212567 0.0003721219 0.004459449 5 72308100 72308813 714 - 0.472 1.026 2.289
ENSG00000113048 E060 199.7834511 0.0348584269 0.0372420679 0.147595878 5 72314081 72314151 71 - 2.340 2.238 -0.340
ENSG00000113048 E061 116.8781811 0.0350027197 0.0867226328 0.257739586 5 72314152 72314158 7 - 2.099 2.023 -0.254
ENSG00000113048 E062 5.2471599 0.0055981247 0.0827520797 0.250212880 5 72320000 72320148 149 - 0.641 0.925 1.137
ENSG00000113048 E063 124.8298726 0.0423124318 0.0825245766 0.249760678 5 72320149 72320180 32 - 2.133 2.043 -0.301
ENSG00000113048 E064 105.6206051 0.0374522365 0.0659523157 0.216056142 5 72320181 72320233 53 - 2.058 1.975 -0.279
ENSG00000113048 E065 5.9760387 0.0993449445 0.8590418221 0.929844387 5 72320234 72320526 293 - 0.788 0.887 0.388
ENSG00000113048 E066 0.2027342 0.0325601898 0.4400198257   5 72320617 72320726 110 - 0.000 0.137 10.855
ENSG00000113048 E067 0.0000000       5 72320727 72320812 86 -      
ENSG00000113048 E068 0.0000000       5 72321508 72321717 210 -