ENSG00000112769

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368638 ENSG00000112769 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMA4 protein_coding protein_coding 6.769537 7.645403 2.964243 1.979795 0.09085571 -1.363956 2.93196814 3.63702767 0.7972636 0.90337103 0.4190208 -2.17560943 0.38910417 0.481666667 0.26156667 -0.22010000 0.732358769 0.001609689 FALSE TRUE
ENST00000389463 ENSG00000112769 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMA4 protein_coding protein_coding 6.769537 7.645403 2.964243 1.979795 0.09085571 -1.363956 0.14138845 0.01790512 0.2349073 0.01790512 0.2349073 3.13363359 0.03416250 0.004833333 0.08303333 0.07820000 0.905845571 0.001609689 FALSE TRUE
ENST00000424408 ENSG00000112769 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMA4 protein_coding protein_coding 6.769537 7.645403 2.964243 1.979795 0.09085571 -1.363956 0.28804169 0.08878837 0.2948225 0.05568620 0.1143130 1.62555604 0.07367917 0.009133333 0.10103333 0.09190000 0.041617928 0.001609689 FALSE TRUE
ENST00000453937 ENSG00000112769 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMA4 protein_coding protein_coding 6.769537 7.645403 2.964243 1.979795 0.09085571 -1.363956 1.11747949 1.60400913 0.3370735 0.35422464 0.3370735 -2.21733564 0.14092500 0.216533333 0.11913333 -0.09740000 0.445197169 0.001609689 FALSE TRUE
ENST00000521398 ENSG00000112769 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMA4 protein_coding protein_coding 6.769537 7.645403 2.964243 1.979795 0.09085571 -1.363956 0.05103539 0.04194500 0.2441219 0.04194500 0.1721879 2.29046368 0.01307917 0.011333333 0.08450000 0.07316667 0.608383376 0.001609689 FALSE TRUE
ENST00000522006 ENSG00000112769 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMA4 protein_coding protein_coding 6.769537 7.645403 2.964243 1.979795 0.09085571 -1.363956 0.70076978 0.65671199 0.6276498 0.17700904 0.3160308 -0.06429944 0.13427083 0.091566667 0.20676667 0.11520000 0.927749793 0.001609689 FALSE TRUE
ENST00000651529 ENSG00000112769 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMA4 protein_coding nonsense_mediated_decay 6.769537 7.645403 2.964243 1.979795 0.09085571 -1.363956 0.73486932 0.80880965 0.0000000 0.35056046 0.0000000 -6.35545620 0.08882083 0.094066667 0.00000000 -0.09406667 0.001609689 0.001609689 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000112769 E001 0.8286205 0.017267182 2.804536e-01   6 112107931 112108756 826 - 0.136 0.328 1.617
ENSG00000112769 E002 0.9419927 0.234625945 3.393414e-01   6 112108757 112108859 103 - 0.136 0.339 1.682
ENSG00000112769 E003 2.9664178 0.013612336 3.910070e-01 6.211366e-01 6 112108860 112109148 289 - 0.506 0.643 0.622
ENSG00000112769 E004 2.5316870 0.114990427 4.394992e-01 6.582890e-01 6 112109149 112109172 24 - 0.452 0.590 0.658
ENSG00000112769 E005 9.0048084 0.044708033 8.716232e-02 2.585622e-01 6 112109173 112109292 120 - 0.835 1.084 0.930
ENSG00000112769 E006 23.8491645 0.012478220 3.571771e-03 2.677181e-02 6 112109293 112109582 290 - 1.216 1.486 0.938
ENSG00000112769 E007 13.3080360 0.130646364 1.352492e-01 3.401247e-01 6 112114076 112114195 120 - 0.965 1.248 1.022
ENSG00000112769 E008 11.2328455 0.042371448 2.678281e-01 5.074467e-01 6 112114663 112114756 94 - 0.977 1.151 0.636
ENSG00000112769 E009 10.7520105 0.005962997 3.718700e-01 6.055314e-01 6 112115863 112115993 131 - 1.009 1.108 0.361
ENSG00000112769 E010 10.9144013 0.003304384 4.614661e-01 6.741816e-01 6 112117739 112117898 160 - 1.024 1.100 0.275
ENSG00000112769 E011 13.6295779 0.011090603 9.683274e-01 9.860069e-01 6 112119156 112119311 156 - 1.155 1.148 -0.023
ENSG00000112769 E012 14.9219809 0.002613390 1.800268e-01 4.040534e-01 6 112120283 112120472 190 - 1.119 1.240 0.431
ENSG00000112769 E013 0.1308682 0.032649190 6.013984e-01   6 112121775 112122013 239 - 0.000 0.108 11.140
ENSG00000112769 E014 8.1246438 0.003692435 4.037938e-03 2.938150e-02 6 112122014 112122060 47 - 0.734 1.079 1.316
ENSG00000112769 E015 11.6244160 0.002942132 1.473728e-01 3.585468e-01 6 112122061 112122201 141 - 1.009 1.155 0.528
ENSG00000112769 E016 12.2739232 0.003042700 7.933955e-01 8.923434e-01 6 112128922 112129075 154 - 1.131 1.109 -0.079
ENSG00000112769 E017 5.4408544 0.005620099 9.086683e-01 9.564424e-01 6 112129876 112129893 18 - 0.789 0.804 0.060
ENSG00000112769 E018 12.6458752 0.003512897 9.276702e-01 9.659030e-01 6 112129894 112130040 147 - 1.119 1.129 0.034
ENSG00000112769 E019 0.0000000       6 112130041 112130159 119 -      
ENSG00000112769 E020 10.9228550 0.004037351 7.551354e-01 8.697614e-01 6 112130968 112131101 134 - 1.081 1.049 -0.117
ENSG00000112769 E021 10.2670415 0.008377921 6.342487e-01 7.930992e-01 6 112132753 112132890 138 - 1.068 1.015 -0.191
ENSG00000112769 E022 7.6064619 0.090298531 2.230037e-01 4.569621e-01 6 112133349 112133487 139 - 1.022 0.833 -0.713
ENSG00000112769 E023 5.7953492 0.006080688 8.544558e-01 9.272840e-01 6 112134467 112134609 143 - 0.815 0.841 0.102
ENSG00000112769 E024 0.0000000       6 112135825 112136122 298 -      
ENSG00000112769 E025 7.5493237 0.005180375 1.071965e-01 2.943368e-01 6 112136123 112136254 132 - 1.025 0.840 -0.694
ENSG00000112769 E026 10.0541533 0.041941349 1.607407e-02 8.208035e-02 6 112139120 112139291 172 - 1.200 0.881 -1.171
ENSG00000112769 E027 8.5103071 0.133412818 1.410330e-01 3.490889e-01 6 112139752 112139885 134 - 1.112 0.851 -0.967
ENSG00000112769 E028 7.2706947 0.212142928 6.316234e-01 7.914481e-01 6 112140760 112140922 163 - 1.011 0.837 -0.658
ENSG00000112769 E029 9.3708126 0.046490043 1.331424e-01 3.367340e-01 6 112141358 112141503 146 - 1.121 0.905 -0.797
ENSG00000112769 E030 4.9541066 0.006113819 7.372827e-02 2.322271e-01 6 112142119 112142143 25 - 0.883 0.643 -0.967
ENSG00000112769 E031 11.3520644 0.003288029 1.514362e-01 3.644174e-01 6 112142144 112142292 149 - 1.154 1.014 -0.508
ENSG00000112769 E032 8.6561281 0.004288531 1.587331e-02 8.133403e-02 6 112144794 112144933 140 - 1.107 0.841 -0.991
ENSG00000112769 E033 10.5248695 0.003614479 3.407399e-02 1.390696e-01 6 112148157 112148336 180 - 1.165 0.950 -0.783
ENSG00000112769 E034 0.3032425 0.027442404 2.784069e-01   6 112150436 112150510 75 - 0.000 0.194 12.086
ENSG00000112769 E035 7.6454673 0.077422727 1.154558e-01 3.082239e-01 6 112150511 112150627 117 - 1.073 0.802 -1.022
ENSG00000112769 E036 5.1795889 0.336956097 6.378541e-01 7.956334e-01 6 112154851 112154947 97 - 0.902 0.689 -0.845
ENSG00000112769 E037 6.1155893 0.152489292 7.873061e-01 8.889558e-01 6 112155565 112155706 142 - 0.851 0.856 0.019
ENSG00000112769 E038 7.4773328 0.201577855 5.466374e-01 7.338872e-01 6 112158732 112158880 149 - 1.015 0.852 -0.615
ENSG00000112769 E039 3.4550706 0.172828145 4.291118e-01 6.503455e-01 6 112165160 112165171 12 - 0.757 0.549 -0.891
ENSG00000112769 E040 6.8639556 0.018847579 6.593784e-02 2.160437e-01 6 112165172 112165276 105 - 1.024 0.782 -0.918
ENSG00000112769 E041 0.5059767 0.022260361 1.320228e-01   6 112171630 112172610 981 - 0.000 0.267 12.628
ENSG00000112769 E042 8.7534485 0.003992070 1.643559e-02 8.341229e-02 6 112172611 112172804 194 - 1.119 0.858 -0.967
ENSG00000112769 E043 8.8098076 0.004223594 7.543275e-03 4.722819e-02 6 112175313 112175480 168 - 1.131 0.841 -1.080
ENSG00000112769 E044 8.5417291 0.041920257 1.025477e-01 2.863173e-01 6 112178121 112178232 112 - 1.094 0.882 -0.787
ENSG00000112769 E045 0.0000000       6 112178233 112179502 1270 -      
ENSG00000112769 E046 0.0000000       6 112179735 112179765 31 -      
ENSG00000112769 E047 0.6368449 0.019269408 6.662840e-02   6 112179766 112179949 184 - 0.000 0.328 12.998
ENSG00000112769 E048 8.0467652 0.061204962 1.508553e-01 3.635306e-01 6 112185237 112185318 82 - 1.076 0.864 -0.791
ENSG00000112769 E049 4.4199988 0.182977882 4.066096e-01 6.335073e-01 6 112185319 112185347 29 - 0.832 0.672 -0.648
ENSG00000112769 E050 12.7099518 0.004603351 6.025534e-03 3.984713e-02 6 112187450 112187601 152 - 1.271 1.013 -0.928
ENSG00000112769 E051 0.6673924 0.019387492 4.508949e-01   6 112188892 112189109 218 - 0.136 0.267 1.203
ENSG00000112769 E052 2.4576961 0.009418993 2.105806e-02 9.954746e-02 6 112189110 112189130 21 - 0.704 0.328 -1.844
ENSG00000112769 E053 9.6780985 0.023716021 9.558861e-04 9.554423e-03 6 112189131 112189205 75 - 1.210 0.785 -1.579
ENSG00000112769 E054 8.8494627 0.004145095 8.270651e-04 8.500041e-03 6 112191636 112191718 83 - 1.155 0.784 -1.383
ENSG00000112769 E055 9.4853823 0.003201830 3.149949e-02 1.317668e-01 6 112191719 112191850 132 - 1.131 0.906 -0.827
ENSG00000112769 E056 0.0000000       6 112200133 112200175 43 -      
ENSG00000112769 E057 7.1253639 0.019310293 2.914938e-01 5.321231e-01 6 112201608 112201688 81 - 0.978 0.840 -0.524
ENSG00000112769 E058 8.2651690 0.018604872 8.451223e-01 9.221950e-01 6 112207021 112207122 102 - 0.978 0.960 -0.069
ENSG00000112769 E059 4.7638720 0.111012618 7.467181e-01 8.647541e-01 6 112207123 112207145 23 - 0.797 0.730 -0.268
ENSG00000112769 E060 0.3641499 0.029370482 8.527950e-01   6 112213543 112213929 387 - 0.136 0.108 -0.380
ENSG00000112769 E061 0.5067846 0.021768165 4.298731e-01   6 112213930 112214070 141 - 0.240 0.108 -1.379
ENSG00000112769 E062 4.7166364 0.043384534 4.368092e-01 6.562998e-01 6 112216368 112216401 34 - 0.818 0.693 -0.506
ENSG00000112769 E063 4.8967132 0.053286844 1.117911e-01 3.020636e-01 6 112216402 112216420 19 - 0.887 0.616 -1.101
ENSG00000112769 E064 4.9992467 0.042798940 2.258692e-01 4.604187e-01 6 112216421 112216469 49 - 0.865 0.670 -0.784
ENSG00000112769 E065 0.0000000       6 112216636 112216754 119 -      
ENSG00000112769 E066 0.2027342 0.033809124 5.987198e-01   6 112253782 112253783 2 - 0.000 0.108 11.141
ENSG00000112769 E067 0.3336024 0.024441170 2.798694e-01   6 112253784 112253789 6 - 0.000 0.195 12.095
ENSG00000112769 E068 10.3083762 0.074990982 4.941833e-03 3.432132e-02 6 112253790 112253955 166 - 0.729 1.202 1.775
ENSG00000112769 E069 56.3280609 0.001766805 1.421282e-11 1.192521e-09 6 112253956 112254291 336 - 1.534 1.877 1.163
ENSG00000112769 E070 1.6118719 0.012048779 6.828470e-01 8.244625e-01 6 112254292 112254401 110 - 0.454 0.382 -0.383
ENSG00000112769 E071 0.7679007 0.066152716 2.888223e-01   6 112254402 112254441 40 - 0.136 0.327 1.609
ENSG00000112769 E072 9.0513825 0.006660525 5.282229e-02 1.863008e-01 6 112254442 112254458 17 - 0.861 1.080 0.814
ENSG00000112769 E073 27.3000592 0.011556182 1.453501e-05 2.899201e-04 6 112254459 112254595 137 - 1.208 1.568 1.251
ENSG00000112769 E074 3.1251204 0.011384204 3.208741e-02 1.334700e-01 6 112254596 112254722 127 - 0.393 0.741 1.615
ENSG00000112769 E075 0.0000000       6 112254786 112254939 154 -