ENSG00000112763

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312541 ENSG00000112763 HEK293_OSMI2_6hA HEK293_TMG_6hB BTN2A1 protein_coding protein_coding 22.46911 14.78057 29.1978 1.188259 1.51563 0.9816759 9.164172 5.9935285 13.0508346 0.1308125 1.74685575 1.121365 0.40467083 0.41106667 0.45593333 0.044866667 9.396135e-01 1.317989e-09 FALSE TRUE
ENST00000377600 ENSG00000112763 HEK293_OSMI2_6hA HEK293_TMG_6hB BTN2A1 protein_coding nonsense_mediated_decay 22.46911 14.78057 29.1978 1.188259 1.51563 0.9816759 1.845511 0.9019372 2.2441817 0.3531965 0.56671701 1.305597 0.07919583 0.05783333 0.07526667 0.017433333 8.926660e-01 1.317989e-09 FALSE TRUE
ENST00000429381 ENSG00000112763 HEK293_OSMI2_6hA HEK293_TMG_6hB BTN2A1 protein_coding protein_coding 22.46911 14.78057 29.1978 1.188259 1.51563 0.9816759 4.119925 3.0901482 5.8685129 0.5795026 0.81631575 0.923114 0.18180833 0.20576667 0.19920000 -0.006566667 9.956753e-01 1.317989e-09 FALSE TRUE
ENST00000541522 ENSG00000112763 HEK293_OSMI2_6hA HEK293_TMG_6hB BTN2A1 protein_coding protein_coding 22.46911 14.78057 29.1978 1.188259 1.51563 0.9816759 3.167975 1.2486551 3.1423924 0.2249319 1.57235681 1.324564 0.13532083 0.08650000 0.10233333 0.015833333 9.748499e-01 1.317989e-09 FALSE TRUE
MSTRG.27809.5 ENSG00000112763 HEK293_OSMI2_6hA HEK293_TMG_6hB BTN2A1 protein_coding   22.46911 14.78057 29.1978 1.188259 1.51563 0.9816759 2.202137 1.2880932 4.0972520 0.6657223 0.30213372 1.661780 0.08974583 0.08103333 0.14003333 0.059000000 6.484434e-01 1.317989e-09 FALSE TRUE
MSTRG.27809.9 ENSG00000112763 HEK293_OSMI2_6hA HEK293_TMG_6hB BTN2A1 protein_coding   22.46911 14.78057 29.1978 1.188259 1.51563 0.9816759 1.485588 1.8233534 0.5642807 0.0627053 0.07785529 -1.674657 0.08687083 0.12546667 0.01923333 -0.106233333 1.317989e-09 1.317989e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000112763 E001 0.6564337 0.0625993976 7.575418e-01   6 26457904 26457921 18 + 0.185 0.252 0.571
ENSG00000112763 E002 1.4896339 0.0314823871 4.679401e-02 0.1720399859 6 26457922 26457949 28 + 0.494 0.144 -2.426
ENSG00000112763 E003 1.8456718 0.0110219960 9.771364e-03 0.0571340838 6 26457950 26457954 5 + 0.592 0.144 -2.888
ENSG00000112763 E004 1.9765400 0.0110549372 4.025816e-02 0.1553809325 6 26457955 26457956 2 + 0.592 0.252 -1.889
ENSG00000112763 E005 4.0181688 0.0601836631 2.470179e-02 0.1113038669 6 26457957 26457960 4 + 0.816 0.468 -1.516
ENSG00000112763 E006 6.3627326 0.0875098584 1.846291e-02 0.0905852417 6 26457961 26457967 7 + 0.976 0.616 -1.434
ENSG00000112763 E007 99.4494592 0.0595563343 8.478225e-02 0.2542745993 6 26457968 26458142 175 + 2.034 1.933 -0.337
ENSG00000112763 E008 78.6041081 0.0005458450 6.035321e-01 0.7725355168 6 26458607 26458718 112 + 1.899 1.914 0.051
ENSG00000112763 E009 172.4978412 1.0983371656 4.670611e-01 0.6780741368 6 26459481 26459828 348 + 2.188 2.288 0.334
ENSG00000112763 E010 12.1963896 0.0050120518 3.676800e-01 0.6021525934 6 26462797 26462897 101 + 1.144 1.093 -0.183
ENSG00000112763 E011 152.9400458 0.0540559068 3.005602e-01 0.5410318864 6 26463244 26463525 282 + 2.183 2.177 -0.020
ENSG00000112763 E012 80.6391544 0.1200456645 1.191016e-01 0.3143934279 6 26465185 26465226 42 + 1.958 1.815 -0.483
ENSG00000112763 E013 155.1213333 0.0749490985 1.406447e-01 0.3485241758 6 26465227 26465406 180 + 2.218 2.137 -0.270
ENSG00000112763 E014 63.9865439 0.0093278158 1.720043e-01 0.3932170102 6 26465953 26465973 21 + 1.824 1.791 -0.112
ENSG00000112763 E015 20.0741722 0.0565271731 1.236031e-01 0.3214397328 6 26465974 26466061 88 + 1.363 1.244 -0.414
ENSG00000112763 E016 66.2588253 0.0007631618 9.492321e-01 0.9767239220 6 26466062 26466088 27 + 1.814 1.847 0.109
ENSG00000112763 E017 38.6938183 0.1727254574 1.267114e-01 0.3265784430 6 26466089 26466335 247 + 1.640 1.511 -0.440
ENSG00000112763 E018 47.2009566 0.3459515527 2.456665e-01 0.4831780090 6 26467719 26467947 229 + 1.593 1.774 0.614
ENSG00000112763 E019 672.4524816 1.2681400504 4.472679e-01 0.6636990221 6 26467948 26469653 1706 + 2.767 2.889 0.404
ENSG00000112763 E020 6.1731953 0.0053268853 3.559501e-05 0.0006240169 6 26474338 26474396 59 + 0.529 1.094 2.260
ENSG00000112763 E021 2.4113499 0.0120039247 3.770442e-03 0.0278566577 6 26476122 26476160 39 + 0.254 0.757 2.569
ENSG00000112763 E022 16.1893978 0.1150334826 2.749849e-03 0.0218698809 6 26476161 26476621 461 + 0.852 1.491 2.293