ENSG00000112701

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000447266 ENSG00000112701 HEK293_OSMI2_6hA HEK293_TMG_6hB SENP6 protein_coding protein_coding 15.33486 6.499204 26.00906 0.906763 0.8795804 1.999016 3.7419774 1.3286356 4.9417835 0.46275936 0.2766522 1.887185 0.2246542 0.1978000 0.18970000 -0.00810000 1.000000e+00 4.03416e-28 FALSE TRUE
ENST00000483859 ENSG00000112701 HEK293_OSMI2_6hA HEK293_TMG_6hB SENP6 protein_coding protein_coding 15.33486 6.499204 26.00906 0.906763 0.8795804 1.999016 3.7589677 0.0000000 8.2678585 0.00000000 0.3117830 9.693114 0.1460458 0.0000000 0.31783333 0.31783333 4.034160e-28 4.03416e-28 FALSE FALSE
MSTRG.28542.6 ENSG00000112701 HEK293_OSMI2_6hA HEK293_TMG_6hB SENP6 protein_coding   15.33486 6.499204 26.00906 0.906763 0.8795804 1.999016 0.8713134 1.8267899 0.5114677 0.17340417 0.5114677 -1.816537 0.1408125 0.2862667 0.02103333 -0.26523333 5.974410e-02 4.03416e-28 FALSE TRUE
MSTRG.28542.8 ENSG00000112701 HEK293_OSMI2_6hA HEK293_TMG_6hB SENP6 protein_coding   15.33486 6.499204 26.00906 0.906763 0.8795804 1.999016 2.2412228 0.7992083 5.0963140 0.08751098 0.3041487 2.657699 0.1521625 0.1312333 0.19563333 0.06440000 5.209187e-01 4.03416e-28 FALSE TRUE
MSTRG.28542.9 ENSG00000112701 HEK293_OSMI2_6hA HEK293_TMG_6hB SENP6 protein_coding   15.33486 6.499204 26.00906 0.906763 0.8795804 1.999016 1.3146076 0.9042278 2.9481368 0.45359834 0.3176566 1.694063 0.0917375 0.1244667 0.11313333 -0.01133333 9.593466e-01 4.03416e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000112701 E001 1.4891860 0.0171424029 1.088027e-01 2.970706e-01 6 75601509 75601879 371 + 0.263 0.545 1.591
ENSG00000112701 E002 9.0403831 0.0032348787 2.468624e-01 4.845460e-01 6 75601880 75601926 47 + 0.929 1.060 0.487
ENSG00000112701 E003 26.8912273 0.0015353710 2.371217e-01 4.732263e-01 6 75601927 75602149 223 + 1.389 1.476 0.300
ENSG00000112701 E004 15.1997614 0.0020583600 8.835980e-01 9.431566e-01 6 75602150 75602206 57 + 1.174 1.190 0.056
ENSG00000112701 E005 8.4034859 0.0038778526 7.749352e-01 8.817224e-01 6 75602207 75602223 17 + 0.940 0.977 0.139
ENSG00000112701 E006 71.5433166 0.0031526952 8.487239e-01 9.241993e-01 6 75602224 75602576 353 + 1.829 1.823 -0.020
ENSG00000112701 E007 0.0000000       6 75620663 75620740 78 +      
ENSG00000112701 E008 75.6656664 0.0005108505 3.623989e-05 6.337521e-04 6 75621532 75621625 94 + 1.897 1.703 -0.653
ENSG00000112701 E009 18.4893115 0.0019841191 5.299970e-04 5.949215e-03 6 75622751 75622858 108 + 1.334 1.000 -1.194
ENSG00000112701 E010 82.5003280 0.0017393976 5.622680e-05 9.220358e-04 6 75623900 75623960 61 + 1.937 1.743 -0.654
ENSG00000112701 E011 87.9622958 0.0016029782 5.374722e-03 3.656710e-02 6 75633581 75633649 69 + 1.949 1.825 -0.418
ENSG00000112701 E012 73.4289737 0.0006554250 6.104429e-03 4.023256e-02 6 75633650 75633703 54 + 1.873 1.748 -0.424
ENSG00000112701 E013 58.8858342 0.0008497952 2.998149e-02 1.272823e-01 6 75633704 75633726 23 + 1.773 1.662 -0.374
ENSG00000112701 E014 95.7844079 0.0005069582 1.570590e-02 8.075911e-02 6 75634707 75634811 105 + 1.979 1.883 -0.322
ENSG00000112701 E015 0.5941213 0.0206686762 8.700085e-01   6 75634812 75635056 245 + 0.211 0.176 -0.321
ENSG00000112701 E016 12.7816884 0.0192821243 2.921211e-01 5.327929e-01 6 75640684 75640686 3 + 1.148 1.019 -0.466
ENSG00000112701 E017 32.6228619 0.0012835059 2.868060e-01 5.275008e-01 6 75640687 75640704 18 + 1.516 1.447 -0.239
ENSG00000112701 E018 2.2138156 0.0090213434 6.263408e-01 7.881452e-01 6 75646511 75646851 341 + 0.458 0.544 0.415
ENSG00000112701 E019 4.5389285 0.0960055597 5.372503e-01 7.271512e-01 6 75647292 75647730 439 + 0.744 0.609 -0.568
ENSG00000112701 E020 93.8948466 0.0017184221 3.543827e-03 2.661287e-02 6 75647731 75647801 71 + 1.975 1.844 -0.439
ENSG00000112701 E021 142.6020570 0.0002855360 4.894959e-04 5.578663e-03 6 75659262 75659407 146 + 2.153 2.039 -0.382
ENSG00000112701 E022 207.2248320 0.0003628978 1.884641e-08 8.319608e-07 6 75663221 75663518 298 + 2.324 2.165 -0.530
ENSG00000112701 E023 148.3333374 0.0005040970 2.155368e-04 2.847604e-03 6 75666712 75666870 159 + 2.170 2.047 -0.411
ENSG00000112701 E024 104.2606664 0.0009005636 1.291805e-01 3.304636e-01 6 75666871 75666941 71 + 2.004 1.944 -0.200
ENSG00000112701 E025 130.7310934 0.0026561093 4.764197e-01 6.845504e-01 6 75670553 75670720 168 + 2.095 2.066 -0.098
ENSG00000112701 E026 64.9172603 0.0040721795 7.739397e-01 8.810982e-01 6 75675435 75675468 34 + 1.791 1.779 -0.041
ENSG00000112701 E027 131.7261822 0.0004422584 2.585820e-01 4.973922e-01 6 75675860 75676054 195 + 2.099 2.062 -0.123
ENSG00000112701 E028 2.8591843 0.0717500161 5.842688e-01 7.598523e-01 6 75676604 75677029 426 + 0.592 0.477 -0.538
ENSG00000112701 E029 25.5109712 0.0015758759 6.010763e-01 7.708735e-01 6 75677030 75677035 6 + 1.382 1.423 0.141
ENSG00000112701 E030 78.3177886 0.0037004380 5.884418e-01 7.626454e-01 6 75677036 75677167 132 + 1.855 1.880 0.086
ENSG00000112701 E031 101.7469920 0.0010841424 7.166824e-01 8.460574e-01 6 75677168 75677256 89 + 1.970 1.984 0.050
ENSG00000112701 E032 1.1901250 0.0537767451 2.893840e-02   6 75677257 75678582 1326 + 0.151 0.545 2.590
ENSG00000112701 E033 103.4952293 0.0004332314 6.749073e-02 2.194214e-01 6 75678583 75678692 110 + 1.962 2.031 0.234
ENSG00000112701 E034 117.3466689 0.0009256323 3.813754e-01 6.133639e-01 6 75678811 75678927 117 + 2.027 2.060 0.111
ENSG00000112701 E035 9.3292053 0.0407550344 1.370994e-01 3.431137e-01 6 75678928 75679867 940 + 0.914 1.114 0.739
ENSG00000112701 E036 121.0872692 0.0004339793 1.265673e-01 3.263565e-01 6 75695804 75695923 120 + 2.036 2.091 0.185
ENSG00000112701 E037 108.5178035 0.0003677878 3.440764e-02 1.399839e-01 6 75697425 75697517 93 + 1.980 2.058 0.263
ENSG00000112701 E038 3.4988623 0.0068213536 8.126024e-01 9.037709e-01 6 75697518 75697989 472 + 0.615 0.653 0.166
ENSG00000112701 E039 276.0414761 0.0003029324 4.313876e-03 3.091250e-02 6 75702645 75703072 428 + 2.386 2.454 0.224
ENSG00000112701 E040 166.1263602 0.0003042768 5.302394e-04 5.951150e-03 6 75709527 75709630 104 + 2.153 2.255 0.343
ENSG00000112701 E041 158.8058466 0.0003391480 1.064726e-03 1.040961e-02 6 75711328 75711416 89 + 2.136 2.235 0.333
ENSG00000112701 E042 137.1200990 0.0097831388 1.687508e-01 3.889245e-01 6 75713513 75713581 69 + 2.078 2.154 0.254
ENSG00000112701 E043 212.7409219 0.0003752638 4.994781e-05 8.310264e-04 6 75713675 75713825 151 + 2.258 2.365 0.358
ENSG00000112701 E044 302.4099578 0.0004802385 1.510510e-08 6.806034e-07 6 75715385 75718281 2897 + 2.402 2.531 0.429