ENSG00000112685

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000230449 ENSG00000112685 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC2 protein_coding protein_coding 16.77227 8.405394 25.29992 1.291421 0.9451071 1.5886 8.320760 5.36307046 12.093856 0.78303194 0.1210115 1.1716480 0.53217500 0.640000000 0.47923333 -0.16076667 6.739081e-03 3.217267e-08 FALSE TRUE
ENST00000475028 ENSG00000112685 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC2 protein_coding processed_transcript 16.77227 8.405394 25.29992 1.291421 0.9451071 1.5886 2.075386 1.83294518 1.045742 0.39651364 0.1339039 -0.8037554 0.17127083 0.213966667 0.04186667 -0.17210000 3.217267e-08 3.217267e-08   FALSE
MSTRG.27503.3 ENSG00000112685 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC2 protein_coding   16.77227 8.405394 25.29992 1.291421 0.9451071 1.5886 1.577731 0.20200317 1.981643 0.10152632 1.0568919 3.2318016 0.07585417 0.021000000 0.07616667 0.05516667 9.013317e-01 3.217267e-08 FALSE TRUE
MSTRG.27503.4 ENSG00000112685 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC2 protein_coding   16.77227 8.405394 25.29992 1.291421 0.9451071 1.5886 1.093044 0.03483772 3.487919 0.03483772 0.6390241 6.2856403 0.04679167 0.003433333 0.14003333 0.13660000 2.901458e-06 3.217267e-08 FALSE TRUE
MSTRG.27503.5 ENSG00000112685 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC2 protein_coding   16.77227 8.405394 25.29992 1.291421 0.9451071 1.5886 2.360550 0.49976776 4.377318 0.09144778 0.7641093 3.1054271 0.10868750 0.059733333 0.17383333 0.11410000 4.558672e-02 3.217267e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000112685 E001 53.81699 0.0009075145 2.871557e-06 7.156684e-05 6 485154 485495 342 - 1.617 1.854 0.803
ENSG00000112685 E002 69.04963 0.0006583492 6.786336e-08 2.624034e-06 6 485496 485666 171 - 1.718 1.960 0.816
ENSG00000112685 E003 45.88207 0.0007929483 6.200599e-05 1.000764e-03 6 485667 485708 42 - 1.551 1.770 0.744
ENSG00000112685 E004 55.71396 0.0006298504 3.696498e-05 6.449711e-04 6 485709 485801 93 - 1.639 1.845 0.696
ENSG00000112685 E005 82.46765 0.0012852628 9.910732e-06 2.080730e-04 6 485802 485935 134 - 1.810 2.002 0.646
ENSG00000112685 E006 190.12865 0.0002635988 3.021657e-04 3.752445e-03 6 485936 486403 468 - 2.203 2.304 0.338
ENSG00000112685 E007 24.63003 0.0021197083 1.502648e-03 1.363819e-02 6 486404 486406 3 - 1.280 1.516 0.817
ENSG00000112685 E008 111.56059 0.0003718622 4.787459e-02 1.747267e-01 6 486407 486633 227 - 1.981 2.055 0.247
ENSG00000112685 E009 102.53014 0.0084481157 3.527354e-01 5.897672e-01 6 486634 486764 131 - 1.948 2.006 0.195
ENSG00000112685 E010 75.60726 0.0199379401 2.968144e-01 5.373307e-01 6 488979 489038 60 - 1.805 1.901 0.325
ENSG00000112685 E011 82.95183 0.0057861897 4.197038e-01 6.434507e-01 6 491125 491186 62 - 1.860 1.908 0.160
ENSG00000112685 E012 94.56769 0.0005857869 3.469857e-01 5.845193e-01 6 497367 497489 123 - 1.921 1.960 0.132
ENSG00000112685 E013 70.94502 0.0028796449 2.571163e-01 4.958919e-01 6 499645 499700 56 - 1.792 1.849 0.194
ENSG00000112685 E014 131.18813 0.0003939778 5.784400e-01 7.561015e-01 6 532469 532610 142 - 2.064 2.085 0.068
ENSG00000112685 E015 137.72066 0.0003613437 8.225650e-01 9.094833e-01 6 549175 549291 117 - 2.096 2.090 -0.021
ENSG00000112685 E016 98.16345 0.0020287954 2.888007e-01 5.294307e-01 6 553854 553920 67 - 1.933 1.982 0.163
ENSG00000112685 E017 82.92933 0.0056102710 9.741920e-01 9.889969e-01 6 555227 555288 62 - 1.874 1.876 0.008
ENSG00000112685 E018 92.02754 0.0004202075 8.683591e-01 9.350432e-01 6 555954 556013 60 - 1.923 1.917 -0.019
ENSG00000112685 E019 116.97749 0.0003372863 5.789996e-01 7.565222e-01 6 556484 556564 81 - 2.029 2.010 -0.064
ENSG00000112685 E020 114.82750 0.0043057012 6.130567e-01 7.790008e-01 6 562784 562845 62 - 2.021 1.993 -0.092
ENSG00000112685 E021 129.23544 0.0010144826 2.120395e-01 4.441630e-01 6 564033 564154 122 - 2.076 2.030 -0.155
ENSG00000112685 E022 116.70480 0.0003490564 7.144227e-01 8.445701e-01 6 564545 564702 158 - 2.027 2.014 -0.041
ENSG00000112685 E023 84.38451 0.0005229444 7.141955e-01 8.444628e-01 6 564864 564929 66 - 1.885 1.871 -0.049
ENSG00000112685 E024 119.90328 0.0004146475 1.698868e-01 3.903173e-01 6 572520 572644 125 - 2.046 1.996 -0.166
ENSG00000112685 E025 130.10774 0.0004164920 3.617304e-01 5.970720e-01 6 576757 576882 126 - 2.077 2.047 -0.103
ENSG00000112685 E026 122.72874 0.0003826621 9.815748e-02 2.785661e-01 6 592469 592587 119 - 2.060 2.001 -0.198
ENSG00000112685 E027 105.15799 0.0004571269 2.087983e-01 4.404157e-01 6 598021 598123 103 - 1.992 1.944 -0.161
ENSG00000112685 E028 83.31331 0.0004642359 1.488049e-04 2.083993e-03 6 598860 598941 82 - 1.919 1.745 -0.585
ENSG00000112685 E029 118.61046 0.0004317055 9.978455e-05 1.491700e-03 6 599080 599225 146 - 2.068 1.920 -0.496
ENSG00000112685 E030 96.48112 0.0004078519 6.560814e-06 1.458347e-04 6 610098 610178 81 - 1.986 1.792 -0.650
ENSG00000112685 E031 119.05404 0.0008273349 2.116077e-06 5.482206e-05 6 617711 617835 125 - 2.074 1.883 -0.642
ENSG00000112685 E032 102.09061 0.0005419819 4.453957e-06 1.041565e-04 6 619430 619543 114 - 2.009 1.814 -0.654
ENSG00000112685 E033 86.36506 0.0005591284 6.834105e-05 1.087406e-03 6 629835 629961 127 - 1.937 1.757 -0.606
ENSG00000112685 E034 112.70605 0.0036106089 1.590122e-03 1.425235e-02 6 632941 633117 177 - 2.047 1.898 -0.501
ENSG00000112685 E035 96.60692 0.0024324389 3.076555e-02 1.296515e-01 6 637701 637861 161 - 1.970 1.869 -0.337
ENSG00000112685 E036 1.66681 0.0121989077 8.384636e-01 9.185615e-01 6 657163 657250 88 - 0.376 0.414 0.213
ENSG00000112685 E037 13.90061 0.0035181150 1.049402e-12 1.070346e-10 6 679143 679514 372 - 0.838 1.494 2.358
ENSG00000112685 E038 15.10638 0.0023039949 7.737086e-05 1.206744e-03 6 689139 689212 74 - 1.034 1.386 1.249
ENSG00000112685 E039 53.35529 0.0008011242 1.909005e-01 4.180237e-01 6 693019 693139 121 - 1.671 1.741 0.237