ENSG00000112655

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000230419 ENSG00000112655 HEK293_OSMI2_6hA HEK293_TMG_6hB PTK7 protein_coding protein_coding 48.70872 70.55525 35.62407 4.880673 0.3022028 -0.9857005 14.486516 5.307329 15.85017069 2.0454676 2.60229738 1.57663473 0.35250000 0.07210000 0.444400000 0.372300000 3.089926e-04 4.038644e-09 FALSE TRUE
ENST00000349241 ENSG00000112655 HEK293_OSMI2_6hA HEK293_TMG_6hB PTK7 protein_coding protein_coding 48.70872 70.55525 35.62407 4.880673 0.3022028 -0.9857005 4.402113 10.421165 1.70195884 1.7189306 0.36696636 -2.60718043 0.08336250 0.14570000 0.047666667 -0.098033333 5.549959e-03 4.038644e-09 FALSE TRUE
ENST00000461389 ENSG00000112655 HEK293_OSMI2_6hA HEK293_TMG_6hB PTK7 protein_coding nonsense_mediated_decay 48.70872 70.55525 35.62407 4.880673 0.3022028 -0.9857005 2.548110 5.123031 0.47148507 0.8225656 0.25051188 -3.41424796 0.04524167 0.07416667 0.013366667 -0.060800000 3.333994e-01 4.038644e-09 FALSE TRUE
ENST00000470019 ENSG00000112655 HEK293_OSMI2_6hA HEK293_TMG_6hB PTK7 protein_coding nonsense_mediated_decay 48.70872 70.55525 35.62407 4.880673 0.3022028 -0.9857005 1.275165 4.620015 0.07700291 0.8484678 0.07700291 -5.73380937 0.02141667 0.06470000 0.002133333 -0.062566667 3.247167e-03 4.038644e-09 FALSE TRUE
ENST00000473339 ENSG00000112655 HEK293_OSMI2_6hA HEK293_TMG_6hB PTK7 protein_coding protein_coding 48.70872 70.55525 35.62407 4.880673 0.3022028 -0.9857005 3.324310 6.893077 3.95767362 1.5100775 0.94403905 -0.79894629 0.06880000 0.10176667 0.110800000 0.009033333 9.692395e-01 4.038644e-09 FALSE FALSE
ENST00000481273 ENSG00000112655 HEK293_OSMI2_6hA HEK293_TMG_6hB PTK7 protein_coding protein_coding 48.70872 70.55525 35.62407 4.880673 0.3022028 -0.9857005 4.821631 7.020070 6.73527057 1.3429672 3.36842980 -0.05966279 0.09927917 0.10296667 0.189366667 0.086400000 1.000000e+00 4.038644e-09 FALSE TRUE
ENST00000489707 ENSG00000112655 HEK293_OSMI2_6hA HEK293_TMG_6hB PTK7 protein_coding protein_coding 48.70872 70.55525 35.62407 4.880673 0.3022028 -0.9857005 9.605245 19.171908 1.80671192 3.7485820 0.92440374 -3.40034465 0.16302083 0.26766667 0.051100000 -0.216566667 4.505295e-01 4.038644e-09 FALSE TRUE
ENST00000494146 ENSG00000112655 HEK293_OSMI2_6hA HEK293_TMG_6hB PTK7 protein_coding nonsense_mediated_decay 48.70872 70.55525 35.62407 4.880673 0.3022028 -0.9857005 1.553449 3.625708 0.00000000 1.1011477 0.00000000 -8.50609264 0.02386667 0.05090000 0.000000000 -0.050900000 4.038644e-09 4.038644e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000112655 E001 0.2922838 0.0266201387 7.017847e-01   6 43076307 43076313 7 + 0.152 0.096 -0.760
ENSG00000112655 E002 0.7567544 0.0326700152 4.236324e-01   6 43076314 43076332 19 + 0.152 0.299 1.237
ENSG00000112655 E003 1.1318630 0.0147087110 1.838625e-01   6 43076333 43076338 6 + 0.152 0.396 1.828
ENSG00000112655 E004 1.1318630 0.0147087110 1.838625e-01   6 43076339 43076341 3 + 0.152 0.396 1.828
ENSG00000112655 E005 6.8189058 0.0041532600 9.013686e-04 9.105534e-03 6 43076342 43076368 27 + 0.546 1.007 1.866
ENSG00000112655 E006 52.9330224 0.0248788020 4.002098e-01 6.284486e-01 6 43076369 43076567 199 + 1.763 1.693 -0.240
ENSG00000112655 E007 0.9811163 0.1857388044 7.290190e-01   6 43076814 43076986 173 + 0.262 0.342 0.531
ENSG00000112655 E008 172.1470920 0.0017924740 2.488974e-15 3.965150e-13 6 43128977 43129264 288 + 2.375 2.111 -0.880
ENSG00000112655 E009 17.8135198 0.0019511910 3.722724e-01 6.058323e-01 6 43129265 43129617 353 + 1.218 1.292 0.261
ENSG00000112655 E010 141.0395965 0.0021857544 5.842721e-24 2.688966e-21 6 43129727 43129829 103 + 2.339 1.965 -1.250
ENSG00000112655 E011 206.1871523 0.0003981778 3.105580e-46 8.113829e-43 6 43130230 43130420 191 + 2.500 2.131 -1.231
ENSG00000112655 E012 126.4841182 0.0038768505 1.369645e-17 2.948001e-15 6 43130511 43130590 80 + 2.290 1.922 -1.234
ENSG00000112655 E013 117.6780545 0.0077460207 8.944410e-12 7.765677e-10 6 43130591 43130661 71 + 2.256 1.892 -1.217
ENSG00000112655 E014 0.9632605 0.0157981925 1.504568e-01   6 43131714 43132015 302 + 0.428 0.175 -1.758
ENSG00000112655 E015 187.2076311 0.0031077438 3.913737e-22 1.475933e-19 6 43132016 43132164 149 + 2.454 2.096 -1.194
ENSG00000112655 E016 174.7757628 0.0010808067 8.348866e-29 6.059101e-26 6 43132421 43132525 105 + 2.417 2.077 -1.135
ENSG00000112655 E017 203.8809123 0.0020807191 8.609207e-20 2.455416e-17 6 43132526 43132687 162 + 2.461 2.162 -0.999
ENSG00000112655 E018 7.4869562 0.0595770788 6.447460e-01 8.000109e-01 6 43132688 43132765 78 + 0.971 0.885 -0.327
ENSG00000112655 E019 17.7507902 0.0154342064 8.960445e-01 9.498226e-01 6 43132766 43133721 956 + 1.270 1.260 -0.035
ENSG00000112655 E020 5.1218894 0.1670230534 2.252054e-01 4.596099e-01 6 43138553 43138848 296 + 0.588 0.865 1.137
ENSG00000112655 E021 189.5292470 0.0003002928 2.003425e-28 1.429528e-25 6 43138849 43138982 134 + 2.428 2.136 -0.975
ENSG00000112655 E022 90.0447169 0.0018213416 4.394743e-14 5.853557e-12 6 43139136 43139150 15 + 2.119 1.801 -1.069
ENSG00000112655 E023 165.5451304 0.0017408642 2.105450e-21 7.297016e-19 6 43139151 43139271 121 + 2.384 2.061 -1.077
ENSG00000112655 E024 161.4032410 0.0058363671 1.251060e-11 1.059116e-09 6 43139406 43139525 120 + 2.369 2.053 -1.058
ENSG00000112655 E025 327.1699084 0.0001938837 1.406132e-05 2.816957e-04 6 43141668 43141817 150 + 2.443 2.532 0.298
ENSG00000112655 E026 345.4820782 0.0001850875 6.685369e-18 1.509746e-15 6 43141931 43142041 111 + 2.404 2.583 0.594
ENSG00000112655 E027 209.8345273 0.0002438485 2.044417e-09 1.125046e-07 6 43142042 43142081 40 + 2.204 2.361 0.526
ENSG00000112655 E028 140.7078833 0.0003063732 4.202829e-06 9.910262e-05 6 43142172 43142187 16 + 2.041 2.188 0.490
ENSG00000112655 E029 292.4056482 0.0002432462 1.141710e-08 5.285339e-07 6 43142188 43142299 112 + 2.369 2.496 0.423
ENSG00000112655 E030 13.4355832 0.0164573024 1.208961e-02 6.682033e-02 6 43142300 43142347 48 + 1.299 1.035 -0.942
ENSG00000112655 E031 13.1931755 0.0322045788 2.707043e-02 1.185177e-01 6 43142348 43142376 29 + 1.290 1.025 -0.947
ENSG00000112655 E032 10.5396398 0.0623784290 1.019978e-01 2.853545e-01 6 43142377 43142378 2 + 1.184 0.949 -0.855
ENSG00000112655 E033 19.5277249 0.0562438924 2.796918e-01 5.197867e-01 6 43142379 43142498 120 + 1.375 1.246 -0.452
ENSG00000112655 E034 10.5379043 0.0708242533 1.750551e-01 3.972257e-01 6 43142499 43142502 4 + 1.160 0.965 -0.712
ENSG00000112655 E035 75.7009078 0.0595349753 2.991254e-01 5.395519e-01 6 43142503 43143384 882 + 1.934 1.827 -0.360
ENSG00000112655 E036 17.3696790 0.0020409671 5.331653e-01 7.243093e-01 6 43143385 43143416 32 + 1.218 1.270 0.183
ENSG00000112655 E037 403.4959965 0.0002172235 2.626472e-11 2.101957e-09 6 43143417 43143620 204 + 2.510 2.637 0.423
ENSG00000112655 E038 4.7621628 0.2831485266 5.996195e-01 7.699575e-01 6 43144299 43144299 1 + 0.641 0.798 0.645
ENSG00000112655 E039 13.7268689 0.1150227195 8.378081e-01 9.182021e-01 6 43144300 43144450 151 + 1.150 1.153 0.012
ENSG00000112655 E040 421.5195148 0.0002466025 9.146502e-07 2.628679e-05 6 43144451 43144606 156 + 2.552 2.643 0.303
ENSG00000112655 E041 5.1283043 0.0907908141 8.441580e-01 9.216545e-01 6 43144607 43145199 593 + 0.781 0.762 -0.075
ENSG00000112655 E042 226.7789492 0.0004362141 1.470194e-02 7.696920e-02 6 43145200 43145219 20 + 2.302 2.363 0.204
ENSG00000112655 E043 517.3900388 0.0014652480 5.882985e-05 9.576019e-04 6 43145220 43145432 213 + 2.638 2.730 0.303
ENSG00000112655 E044 9.6372853 0.0553815575 2.611068e-01 5.001510e-01 6 43145433 43146164 732 + 0.905 1.063 0.586
ENSG00000112655 E045 321.4517467 0.0002647422 2.541349e-09 1.365758e-07 6 43146618 43146698 81 + 2.409 2.537 0.426
ENSG00000112655 E046 378.8793290 0.0001880561 2.604400e-12 2.495977e-10 6 43158817 43158968 152 + 2.475 2.612 0.455
ENSG00000112655 E047 488.1447559 0.0021857752 1.005125e-08 4.721808e-07 6 43159788 43159966 179 + 2.570 2.724 0.513
ENSG00000112655 E048 1383.4292777 0.0007363631 2.126060e-27 1.388669e-24 6 43160721 43161719 999 + 3.022 3.177 0.515