ENSG00000112584

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000476287 ENSG00000112584 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM120B protein_coding protein_coding 10.33354 8.587584 12.6616 1.251314 0.6441845 0.559596 5.5718587 4.2779657 8.09263384 0.7095411 1.24255357 0.9180976 0.51404167 0.49683333 0.633500000 0.13666667 5.892706e-01 3.055302e-06 FALSE  
MSTRG.29327.11 ENSG00000112584 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM120B protein_coding   10.33354 8.587584 12.6616 1.251314 0.6441845 0.559596 0.2920192 0.5830341 0.00000000 0.2326709 0.00000000 -5.8900432 0.03794583 0.07563333 0.000000000 -0.07563333 4.068382e-03 3.055302e-06 FALSE  
MSTRG.29327.22 ENSG00000112584 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM120B protein_coding   10.33354 8.587584 12.6616 1.251314 0.6441845 0.559596 0.7090049 0.2754622 0.98935542 0.2231651 0.12152076 1.8076983 0.06455000 0.03006667 0.079600000 0.04953333 5.453039e-01 3.055302e-06 FALSE  
MSTRG.29327.4 ENSG00000112584 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM120B protein_coding   10.33354 8.587584 12.6616 1.251314 0.6441845 0.559596 1.0752090 0.2521771 1.94015715 0.2003401 0.43744758 2.8949768 0.09247500 0.02770000 0.154233333 0.12653333 2.495651e-01 3.055302e-06 FALSE  
MSTRG.29327.9 ENSG00000112584 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM120B protein_coding   10.33354 8.587584 12.6616 1.251314 0.6441845 0.559596 0.3679997 0.7340037 0.03154154 0.1833076 0.03154154 -4.1626833 0.04305417 0.08250000 0.002366667 -0.08013333 3.055302e-06 3.055302e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000112584 E001 0.0000000       6 170290604 170290702 99 +      
ENSG00000112584 E002 0.2027342 0.0342145610 3.847953e-01   6 170290703 170291072 370 + 0.000 0.137 9.523
ENSG00000112584 E003 0.1308682 0.0326491905 3.868968e-01   6 170295321 170295453 133 + 0.000 0.136 11.855
ENSG00000112584 E004 2.5765604 0.0086985601 1.222443e-01 3.194175e-01 6 170306692 170306743 52 + 0.642 0.394 -1.196
ENSG00000112584 E005 2.4398952 0.0100788091 4.116901e-01 6.372950e-01 6 170306744 170306745 2 + 0.582 0.454 -0.610
ENSG00000112584 E006 2.6178790 0.0102505118 3.088542e-01 5.493469e-01 6 170306746 170306749 4 + 0.613 0.454 -0.748
ENSG00000112584 E007 2.4564633 0.0378687873 4.392157e-01 6.581454e-01 6 170306750 170306750 1 + 0.582 0.455 -0.606
ENSG00000112584 E008 4.3420257 0.0062667950 4.786961e-01 6.862537e-01 6 170306751 170306757 7 + 0.763 0.671 -0.376
ENSG00000112584 E009 11.0610671 0.0036016981 1.100181e-01 2.990334e-01 6 170306758 170306773 16 + 1.145 0.993 -0.553
ENSG00000112584 E010 31.4623615 0.0012874811 2.797979e-02 1.212053e-01 6 170306774 170306842 69 + 1.563 1.434 -0.441
ENSG00000112584 E011 384.3071569 0.0001836057 2.180729e-08 9.488545e-07 6 170317370 170318439 1070 + 2.619 2.532 -0.291
ENSG00000112584 E012 67.4172375 0.0013856412 2.275444e-02 1.051357e-01 6 170318440 170318462 23 + 1.874 1.781 -0.313
ENSG00000112584 E013 59.1358600 0.0009385291 4.519998e-03 3.204608e-02 6 170318463 170318475 13 + 1.829 1.706 -0.417
ENSG00000112584 E014 70.6639550 0.0006303720 2.732983e-03 2.176122e-02 6 170318476 170318511 36 + 1.901 1.784 -0.395
ENSG00000112584 E015 81.6167845 0.0038865298 7.510731e-03 4.708360e-02 6 170318512 170318570 59 + 1.963 1.843 -0.402
ENSG00000112584 E016 75.1484735 0.0006552625 1.226368e-03 1.162520e-02 6 170318571 170318619 49 + 1.927 1.802 -0.420
ENSG00000112584 E017 62.5334064 0.0007334250 1.870747e-03 1.620154e-02 6 170318620 170318642 23 + 1.856 1.724 -0.444
ENSG00000112584 E018 54.9602037 0.0016440751 7.809594e-03 4.843063e-02 6 170318643 170318655 13 + 1.794 1.670 -0.421
ENSG00000112584 E019 64.5009432 0.0007511101 2.820208e-03 2.231555e-02 6 170318656 170318691 36 + 1.861 1.737 -0.420
ENSG00000112584 E020 63.3777104 0.0063574489 1.373086e-03 1.271230e-02 6 170318692 170318727 36 + 1.871 1.692 -0.602
ENSG00000112584 E021 82.4309458 0.0021871206 3.912069e-02 1.524704e-01 6 170318728 170318786 59 + 1.948 1.870 -0.263
ENSG00000112584 E022 60.5400034 0.0007893229 1.530559e-01 3.666894e-01 6 170318787 170318799 13 + 1.813 1.759 -0.182
ENSG00000112584 E023 218.9217293 0.0003285911 9.625759e-01 9.832290e-01 6 170318800 170319124 325 + 2.334 2.345 0.036
ENSG00000112584 E024 147.4211633 0.0026692207 3.826810e-02 1.502996e-01 6 170323079 170323259 181 + 2.126 2.217 0.306
ENSG00000112584 E025 89.0417593 0.0032514446 5.676224e-02 1.954488e-01 6 170330449 170330550 102 + 1.905 2.003 0.330
ENSG00000112584 E026 103.7553136 0.0024167704 1.164177e-01 3.098468e-01 6 170348151 170348323 173 + 1.983 2.061 0.263
ENSG00000112584 E027 69.7821378 0.0013217190 1.145858e-03 1.101574e-02 6 170358226 170358318 93 + 1.775 1.930 0.522
ENSG00000112584 E028 135.7541310 0.0044376639 3.058556e-03 2.376307e-02 6 170388287 170388493 207 + 2.070 2.207 0.461
ENSG00000112584 E029 119.4907831 0.0004774232 1.803932e-06 4.759931e-05 6 170391013 170391121 109 + 1.997 2.164 0.559
ENSG00000112584 E030 124.3827461 0.0056687578 6.978279e-04 7.427127e-03 6 170395487 170395579 93 + 2.014 2.181 0.560
ENSG00000112584 E031 6.3506597 0.8105297113 1.769356e-01 3.996560e-01 6 170404179 170404549 371 + 0.323 1.146 3.561
ENSG00000112584 E032 94.5685003 0.0104795464 3.025588e-04 3.756778e-03 6 170404550 170404601 52 + 1.864 2.088 0.754
ENSG00000112584 E033 326.1800770 0.0001689725 1.106622e-03 1.071800e-02 6 170404763 170407067 2305 + 2.479 2.552 0.244