ENSG00000112531

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361195 ENSG00000112531 HEK293_OSMI2_6hA HEK293_TMG_6hB QKI protein_coding protein_coding 26.22462 8.821007 47.78522 1.915306 2.871654 2.436217 5.2175034 2.5609652 12.6951280 0.4070065 1.1054419 2.3050289 0.2849417 0.30103333 0.265166667 -0.03586667 0.82769969 0.02314364 FALSE TRUE
ENST00000361752 ENSG00000112531 HEK293_OSMI2_6hA HEK293_TMG_6hB QKI protein_coding protein_coding 26.22462 8.821007 47.78522 1.915306 2.871654 2.436217 3.3861276 1.2148993 1.5419841 0.5756800 0.8737423 0.3414507 0.1042458 0.12313333 0.034666667 -0.08846667 0.64519625 0.02314364 FALSE TRUE
ENST00000537883 ENSG00000112531 HEK293_OSMI2_6hA HEK293_TMG_6hB QKI protein_coding protein_coding 26.22462 8.821007 47.78522 1.915306 2.871654 2.436217 0.5307316 0.5934817 0.4450318 0.4346284 0.2340789 -0.4073427 0.0590875 0.05503333 0.008866667 -0.04616667 0.78968145 0.02314364 FALSE FALSE
ENST00000544823 ENSG00000112531 HEK293_OSMI2_6hA HEK293_TMG_6hB QKI protein_coding protein_coding 26.22462 8.821007 47.78522 1.915306 2.871654 2.436217 15.0255805 3.9542182 29.0015404 0.7727072 2.5900026 2.8715186 0.4723958 0.45443333 0.604666667 0.15023333 0.02314364 0.02314364 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000112531 E001 2.3861197 0.1314042153 1.234791e-01 3.212515e-01 6 163414000 163414642 643 + 0.357 0.701 1.654
ENSG00000112531 E002 3.2621137 0.0080141167 6.717315e-02 2.187659e-01 6 163414643 163414717 75 + 0.459 0.801 1.503
ENSG00000112531 E003 19.8861602 0.0076687599 2.389030e-03 1.961668e-02 6 163414718 163415169 452 + 1.137 1.478 1.195
ENSG00000112531 E004 21.2784624 0.0157008060 6.191407e-01 7.832285e-01 6 163415170 163415193 24 + 1.224 1.345 0.425
ENSG00000112531 E005 60.5197970 0.0006350537 2.201627e-01 4.537297e-01 6 163415194 163415237 44 + 1.692 1.689 -0.009
ENSG00000112531 E006 129.7561221 0.0014047513 1.042543e-03 1.023634e-02 6 163415238 163415335 98 + 2.032 1.957 -0.251
ENSG00000112531 E007 0.1723744 0.0865201422 1.190321e-01   6 163416315 163416486 172 + 0.000 0.222 11.037
ENSG00000112531 E008 0.0000000       6 163423134 163423207 74 +      
ENSG00000112531 E009 0.0000000       6 163423208 163423213 6 +      
ENSG00000112531 E010 0.0000000       6 163423214 163423592 379 +      
ENSG00000112531 E011 0.0000000       6 163428995 163429017 23 +      
ENSG00000112531 E012 0.0000000       6 163455216 163455278 63 +      
ENSG00000112531 E013 131.2736139 0.0008256466 2.726715e-06 6.837845e-05 6 163455279 163455330 52 + 2.045 1.914 -0.441
ENSG00000112531 E014 190.8297408 0.0003050510 2.091239e-08 9.134269e-07 6 163455331 163455421 91 + 2.202 2.079 -0.411
ENSG00000112531 E015 0.3206185 0.0274424043 1.000000e+00   6 163457381 163457551 171 + 0.118 0.000 -10.889
ENSG00000112531 E016 223.1771567 0.0002632907 3.597680e-07 1.157138e-05 6 163478780 163478896 117 + 2.265 2.176 -0.298
ENSG00000112531 E017 0.4632531 0.0255023523 5.803664e-01   6 163534959 163534981 23 + 0.167 0.000 -11.503
ENSG00000112531 E018 203.6299458 0.0002410181 1.063337e-05 2.212980e-04 6 163534982 163535079 98 + 2.224 2.152 -0.241
ENSG00000112531 E019 123.0592136 0.0009349269 8.024100e-03 4.942428e-02 6 163535080 163535125 46 + 2.004 1.961 -0.146
ENSG00000112531 E020 147.0012223 0.0004396665 1.945238e-01 4.227512e-01 6 163561982 163562069 88 + 2.068 2.089 0.068
ENSG00000112531 E021 94.1917006 0.0006340790 5.913529e-01 7.646501e-01 6 163563420 163563443 24 + 1.872 1.914 0.142
ENSG00000112531 E022 268.1936907 0.0023951715 5.851591e-01 7.604143e-01 6 163563444 163563719 276 + 2.322 2.370 0.161
ENSG00000112531 E023 29.4720624 0.0471777085 7.899707e-04 8.198692e-03 6 163563720 163564666 947 + 1.443 0.985 -1.624
ENSG00000112531 E024 46.6345169 0.1247750239 8.043855e-03 4.951005e-02 6 163564667 163565945 1279 + 1.638 1.158 -1.666
ENSG00000112531 E025 41.4235360 0.0074635813 4.203508e-05 7.178003e-04 6 163565946 163566457 512 + 1.571 1.263 -1.066
ENSG00000112531 E026 24.2065620 0.0020594409 6.511561e-06 1.448726e-04 6 163566458 163566720 263 + 1.365 0.953 -1.476
ENSG00000112531 E027 151.1743835 0.0022122737 8.116102e-02 2.471579e-01 6 163566721 163566795 75 + 2.086 2.078 -0.025
ENSG00000112531 E028 69.9731422 0.0005253470 1.467041e-06 3.968419e-05 6 163566796 163569437 2642 + 1.786 1.575 -0.716
ENSG00000112531 E029 15.8895599 0.0023230255 5.651184e-01 7.468449e-01 6 163569438 163570145 708 + 1.131 1.135 0.013
ENSG00000112531 E030 1862.5903621 0.0018749228 1.576392e-19 4.338860e-17 6 163570694 163578592 7899 + 3.128 3.305 0.586