ENSG00000112514

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374484 ENSG00000112514 HEK293_OSMI2_6hA HEK293_TMG_6hB CUTA protein_coding nonsense_mediated_decay 369.4147 547.9408 192.0047 90.20095 5.366055 -1.51283 44.16242 68.68161 18.63524 13.33079 2.8986847 -1.881327 0.1155167 0.1260333 0.09656667 -0.02946667 0.69268842 1.090301e-14 TRUE  
ENST00000440279 ENSG00000112514 HEK293_OSMI2_6hA HEK293_TMG_6hB CUTA protein_coding protein_coding 369.4147 547.9408 192.0047 90.20095 5.366055 -1.51283 79.60230 120.26879 32.50820 19.43568 0.8191581 -1.887063 0.2057833 0.2201000 0.16933333 -0.05076667 0.01273746 1.090301e-14 FALSE  
ENST00000488034 ENSG00000112514 HEK293_OSMI2_6hA HEK293_TMG_6hB CUTA protein_coding protein_coding 369.4147 547.9408 192.0047 90.20095 5.366055 -1.51283 68.58741 92.65122 38.05976 17.47540 1.8727470 -1.283320 0.1968167 0.1691000 0.19800000 0.02890000 0.65486691 1.090301e-14 FALSE  
ENST00000607266 ENSG00000112514 HEK293_OSMI2_6hA HEK293_TMG_6hB CUTA protein_coding protein_coding 369.4147 547.9408 192.0047 90.20095 5.366055 -1.51283 93.67989 129.33776 59.69732 25.00956 0.9743248 -1.115275 0.2580125 0.2335000 0.31123333 0.07773333 0.10922685 1.090301e-14 FALSE  
MSTRG.28142.5 ENSG00000112514 HEK293_OSMI2_6hA HEK293_TMG_6hB CUTA protein_coding   369.4147 547.9408 192.0047 90.20095 5.366055 -1.51283 44.31005 67.52980 23.74689 14.00366 2.4101806 -1.507392 0.1224542 0.1226000 0.12330000 0.00070000 1.00000000 1.090301e-14 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000112514 E001 4.519032 6.702683e-03 7.805775e-01 8.850880e-01 6 33416442 33416534 93 - 0.713 0.670 -0.179
ENSG00000112514 E002 6.797609 4.167604e-03 7.885916e-01 8.897045e-01 6 33416535 33416541 7 - 0.803 0.841 0.151
ENSG00000112514 E003 8.036397 3.909839e-03 6.384383e-01 7.960055e-01 6 33416542 33416542 1 - 0.941 0.883 -0.220
ENSG00000112514 E004 21.362354 8.648596e-03 2.011790e-01 4.311835e-01 6 33416543 33416549 7 - 1.183 1.313 0.456
ENSG00000112514 E005 35.799717 1.125133e-03 2.496399e-05 4.608109e-04 6 33416550 33416550 1 - 1.216 1.555 1.176
ENSG00000112514 E006 36.002451 1.084096e-03 2.133482e-05 4.039178e-04 6 33416551 33416551 1 - 1.216 1.558 1.183
ENSG00000112514 E007 99.321967 4.924873e-03 6.995391e-01 8.353279e-01 6 33416552 33416560 9 - 1.939 1.921 -0.060
ENSG00000112514 E008 859.682373 1.159808e-04 7.071250e-05 1.119371e-03 6 33416561 33416618 58 - 2.813 2.873 0.201
ENSG00000112514 E009 1032.673528 1.326822e-04 2.118728e-03 1.786627e-02 6 33416619 33416660 42 - 2.906 2.949 0.143
ENSG00000112514 E010 1921.973865 7.338342e-05 5.950764e-01 7.670805e-01 6 33416661 33416748 88 - 3.213 3.208 -0.019
ENSG00000112514 E011 1847.281214 7.986133e-05 6.220169e-07 1.878918e-05 6 33416749 33416776 28 - 3.229 3.179 -0.165
ENSG00000112514 E012 24.824441 1.851053e-02 2.914315e-03 2.288849e-02 6 33416777 33416919 143 - 1.549 1.251 -1.033
ENSG00000112514 E013 2127.542283 5.303311e-05 3.015083e-09 1.588184e-07 6 33416920 33416969 50 - 3.293 3.240 -0.177
ENSG00000112514 E014 33.516400 3.047261e-02 1.813118e-02 8.945645e-02 6 33416970 33417096 127 - 1.648 1.387 -0.893
ENSG00000112514 E015 1750.399229 5.777554e-05 1.121366e-10 7.875672e-09 6 33417097 33417142 46 - 3.217 3.153 -0.212
ENSG00000112514 E016 24.909070 5.591156e-02 1.061677e-01 2.926428e-01 6 33417143 33417246 104 - 1.500 1.274 -0.783
ENSG00000112514 E017 17.275151 4.563442e-02 5.861810e-02 1.996811e-01 6 33417247 33417250 4 - 1.375 1.112 -0.927
ENSG00000112514 E018 2224.649970 1.066641e-04 1.223167e-01 3.194768e-01 6 33417251 33417310 60 - 3.283 3.268 -0.053
ENSG00000112514 E019 25.109620 4.252002e-02 3.917185e-02 1.526138e-01 6 33417311 33417480 170 - 1.533 1.264 -0.930
ENSG00000112514 E020 3606.012279 4.309913e-05 1.989261e-05 3.805161e-04 6 33417481 33417695 215 - 3.459 3.488 0.095
ENSG00000112514 E021 463.631913 1.863824e-04 5.233126e-09 2.616147e-07 6 33417696 33417816 121 - 2.493 2.617 0.411
ENSG00000112514 E022 254.865773 2.012948e-04 6.360037e-04 6.891345e-03 6 33417817 33417868 52 - 2.260 2.355 0.317
ENSG00000112514 E023 359.682746 1.900537e-04 6.425585e-06 1.431849e-04 6 33417869 33417958 90 - 2.398 2.505 0.358
ENSG00000112514 E024 477.982661 2.803026e-04 1.769573e-02 8.800087e-02 6 33417959 33417983 25 - 2.568 2.617 0.162
ENSG00000112514 E025 521.826606 1.563687e-03 1.737960e-01 3.955951e-01 6 33417984 33418010 27 - 2.618 2.649 0.103
ENSG00000112514 E026 502.420398 1.751689e-03 1.905463e-01 4.176007e-01 6 33418011 33418086 76 - 2.601 2.633 0.107
ENSG00000112514 E027 773.559322 1.111467e-04 2.638625e-02 1.164290e-01 6 33418087 33418201 115 - 2.787 2.821 0.115
ENSG00000112514 E028 59.342535 1.176677e-02 5.266881e-02 1.858996e-01 6 33418202 33418317 116 - 1.808 1.674 -0.456