ENSG00000112294

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357578 ENSG00000112294 HEK293_OSMI2_6hA HEK293_TMG_6hB ALDH5A1 protein_coding protein_coding 18.22434 16.93755 19.15214 3.285923 1.518285 0.1771823 6.2447311 6.0580665 4.364165 1.3446134 0.8079616 -0.472229310 0.33940000 0.3602000 0.2380667 -0.12213333 5.836047e-01 2.039305e-08 FALSE TRUE
ENST00000491546 ENSG00000112294 HEK293_OSMI2_6hA HEK293_TMG_6hB ALDH5A1 protein_coding protein_coding 18.22434 16.93755 19.15214 3.285923 1.518285 0.1771823 1.7515077 1.6997688 1.692124 0.2552393 0.1963710 -0.006465443 0.09527917 0.1064667 0.0880000 -0.01846667 8.787739e-01 2.039305e-08 FALSE TRUE
ENST00000672352 ENSG00000112294 HEK293_OSMI2_6hA HEK293_TMG_6hB ALDH5A1 protein_coding protein_coding 18.22434 16.93755 19.15214 3.285923 1.518285 0.1771823 3.1214966 2.2887660 5.191328 1.2569383 0.9372026 1.178020274 0.16743333 0.1134333 0.2662667 0.15283333 6.971380e-01 2.039305e-08 FALSE TRUE
MSTRG.27729.11 ENSG00000112294 HEK293_OSMI2_6hA HEK293_TMG_6hB ALDH5A1 protein_coding   18.22434 16.93755 19.15214 3.285923 1.518285 0.1771823 0.7043851 0.1660134 1.765843 0.1294710 0.2465360 3.334747088 0.03918333 0.0148000 0.0917000 0.07690000 1.261092e-01 2.039305e-08 FALSE TRUE
MSTRG.27729.3 ENSG00000112294 HEK293_OSMI2_6hA HEK293_TMG_6hB ALDH5A1 protein_coding   18.22434 16.93755 19.15214 3.285923 1.518285 0.1771823 0.8538585 0.9654140 0.000000 0.3251015 0.0000000 -6.607942839 0.04535000 0.0530000 0.0000000 -0.05300000 2.039305e-08 2.039305e-08 FALSE TRUE
MSTRG.27729.7 ENSG00000112294 HEK293_OSMI2_6hA HEK293_TMG_6hB ALDH5A1 protein_coding   18.22434 16.93755 19.15214 3.285923 1.518285 0.1771823 4.0805314 4.9235004 4.069277 0.7310536 0.2836973 -0.274298049 0.23214583 0.2978000 0.2129667 -0.08483333 1.879962e-01 2.039305e-08 FALSE TRUE
MSTRG.27729.8 ENSG00000112294 HEK293_OSMI2_6hA HEK293_TMG_6hB ALDH5A1 protein_coding   18.22434 16.93755 19.15214 3.285923 1.518285 0.1771823 0.6282068 0.0000000 1.194664 0.0000000 0.5973492 6.912487018 0.03311667 0.0000000 0.0578000 0.05780000 2.736229e-01 2.039305e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000112294 E001 26.1440928 0.0288672207 9.229734e-03 5.483856e-02 6 24494867 24494968 102 + 1.276 1.539 0.910
ENSG00000112294 E002 25.5819788 0.3516690223 1.110146e-01 3.006400e-01 6 24494969 24495075 107 + 1.205 1.554 1.212
ENSG00000112294 E003 20.9671167 0.0021070171 1.369325e-10 9.437618e-09 6 24495076 24495233 158 + 0.962 1.512 1.947
ENSG00000112294 E004 10.4155140 0.0138808734 3.287057e-04 4.024062e-03 6 24495234 24495235 2 + 0.762 1.198 1.628
ENSG00000112294 E005 34.8669247 0.0018923393 6.375465e-04 6.901898e-03 6 24495236 24495350 115 + 1.418 1.636 0.746
ENSG00000112294 E006 1.7617087 0.0591643543 6.687791e-01 8.154020e-01 6 24496820 24496983 164 + 0.484 0.402 -0.428
ENSG00000112294 E007 10.8783222 0.1378576420 1.936229e-01 4.216078e-01 6 24501409 24502522 1114 + 1.185 0.943 -0.881
ENSG00000112294 E008 71.4750674 0.0051995557 3.143341e-01 5.545460e-01 6 24502523 24502606 84 + 1.887 1.831 -0.188
ENSG00000112294 E009 0.3040503 0.0244411696 1.751463e-01   6 24502607 24502763 157 + 0.225 0.000 -11.652
ENSG00000112294 E010 132.2939665 0.0009106080 3.747645e-01 6.079538e-01 6 24503263 24503433 171 + 2.138 2.112 -0.090
ENSG00000112294 E011 82.5044973 0.0165749475 4.163311e-01 6.408806e-01 6 24504869 24504899 31 + 1.895 1.948 0.180
ENSG00000112294 E012 109.4723764 0.0005735774 2.311754e-01 4.664911e-01 6 24504900 24504985 86 + 2.022 2.066 0.148
ENSG00000112294 E013 12.2440242 0.0026338316 2.897889e-01 5.303629e-01 6 24511830 24511868 39 + 1.175 1.079 -0.345
ENSG00000112294 E014 0.7448680 0.1275033707 9.059318e-01   6 24515125 24515166 42 + 0.226 0.210 -0.137
ENSG00000112294 E015 126.4286872 0.0003497822 5.141599e-01 7.110843e-01 6 24515167 24515310 144 + 2.114 2.097 -0.057
ENSG00000112294 E016 0.2617363 0.0842164954 2.535485e-01   6 24515311 24515712 402 + 0.000 0.205 10.152
ENSG00000112294 E017 146.5759590 0.0003620914 2.578450e-01 4.966050e-01 6 24520401 24520544 144 + 2.185 2.156 -0.099
ENSG00000112294 E018 0.2735028 0.0257950302 9.351724e-01   6 24522638 24522766 129 + 0.127 0.116 -0.157
ENSG00000112294 E019 156.1476999 0.0003560225 4.871471e-01 6.920067e-01 6 24522767 24522925 159 + 2.205 2.189 -0.055
ENSG00000112294 E020 1.6425917 0.0547740596 2.870538e-01 5.278308e-01 6 24523605 24523942 338 + 0.304 0.499 1.085
ENSG00000112294 E021 168.4004899 0.0003143461 1.983968e-03 1.696322e-02 6 24527997 24528166 170 + 2.180 2.268 0.294
ENSG00000112294 E022 0.8703143 0.3429476486 7.082454e-01   6 24532010 24532118 109 + 0.226 0.290 0.472
ENSG00000112294 E023 101.1401087 0.0005023979 1.743840e-02 8.706538e-02 6 24532119 24532177 59 + 1.960 2.049 0.298
ENSG00000112294 E024 152.8280539 0.0003287468 3.555705e-01 5.921917e-01 6 24533507 24533687 181 + 2.170 2.201 0.101
ENSG00000112294 E025 508.8922190 0.0007206647 1.034951e-12 1.057512e-10 6 24533688 24535518 1831 + 2.768 2.647 -0.401
ENSG00000112294 E026 330.9329509 0.0057358478 3.790980e-01 6.114828e-01 6 24535519 24536509 991 + 2.530 2.511 -0.064
ENSG00000112294 E027 298.8333366 0.0090782197 2.254373e-01 4.598732e-01 6 24536510 24537207 698 + 2.435 2.509 0.247
ENSG00000112294 E028 3.5838845 0.0640680521 8.341684e-01 9.161109e-01 6 24543128 24543312 185 + 0.640 0.673 0.140