ENSG00000112282

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354577 ENSG00000112282 HEK293_OSMI2_6hA HEK293_TMG_6hB MED23 protein_coding protein_coding 14.94528 5.404954 27.89211 1.024785 0.6475668 2.365353 0.7485689 0.5030679 0.1898357 0.191130910 0.1898357 -1.360336 0.07906667 0.10000000 0.006866667 -0.09313333 0.12464331 0.01381873 FALSE TRUE
ENST00000368068 ENSG00000112282 HEK293_OSMI2_6hA HEK293_TMG_6hB MED23 protein_coding protein_coding 14.94528 5.404954 27.89211 1.024785 0.6475668 2.365353 4.8080134 3.0101393 9.7895138 0.705237818 0.2650531 1.698095 0.40547500 0.54486667 0.350966667 -0.19390000 0.01381873 0.01381873 FALSE TRUE
ENST00000479213 ENSG00000112282 HEK293_OSMI2_6hA HEK293_TMG_6hB MED23 protein_coding processed_transcript 14.94528 5.404954 27.89211 1.024785 0.6475668 2.365353 0.7366182 0.2804001 1.3112172 0.102372640 0.1272553 2.185754 0.06215417 0.06660000 0.046933333 -0.01966667 0.98164332 0.01381873 FALSE TRUE
ENST00000484885 ENSG00000112282 HEK293_OSMI2_6hA HEK293_TMG_6hB MED23 protein_coding processed_transcript 14.94528 5.404954 27.89211 1.024785 0.6475668 2.365353 1.6886777 0.7241033 2.8874680 0.009549652 0.6524941 1.980738 0.11598333 0.14616667 0.102633333 -0.04353333 0.75401072 0.01381873   FALSE
MSTRG.28962.2 ENSG00000112282 HEK293_OSMI2_6hA HEK293_TMG_6hB MED23 protein_coding   14.94528 5.404954 27.89211 1.024785 0.6475668 2.365353 2.0432217 0.4425032 3.6043773 0.442503219 0.1139261 2.997747 0.12545833 0.06986667 0.129200000 0.05933333 0.43383246 0.01381873 FALSE TRUE
MSTRG.28962.6 ENSG00000112282 HEK293_OSMI2_6hA HEK293_TMG_6hB MED23 protein_coding   14.94528 5.404954 27.89211 1.024785 0.6475668 2.365353 3.6135152 0.2595087 7.0676696 0.259508671 0.6892492 4.714871 0.15361667 0.03980000 0.254600000 0.21480000 0.15639957 0.01381873 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000112282 E001 0.8993890 0.0172671820 1.377930e-02   6 131573966 131573982 17 - 0.120 0.557 3.034
ENSG00000112282 E002 15.3985501 0.0122731112 7.172677e-05 1.133208e-03 6 131573983 131574295 313 - 0.997 1.404 1.446
ENSG00000112282 E003 0.8934720 0.6860242394 2.443425e-01   6 131586732 131586737 6 - 0.117 0.499 2.808
ENSG00000112282 E004 1.3401570 0.5450131109 4.838718e-01   6 131586738 131586748 11 - 0.247 0.496 1.476
ENSG00000112282 E005 16.6315799 0.0241825755 1.015360e-02 5.878211e-02 6 131586749 131586937 189 - 1.068 1.370 1.069
ENSG00000112282 E006 55.0404893 0.0008292395 1.658622e-10 1.125788e-08 6 131586938 131587202 265 - 1.561 1.893 1.124
ENSG00000112282 E007 26.7984877 0.0014258372 1.190826e-07 4.340623e-06 6 131587203 131587244 42 - 1.245 1.625 1.312
ENSG00000112282 E008 173.8957398 0.0003318478 3.586103e-03 2.685378e-02 6 131587245 131587708 464 - 2.127 2.217 0.303
ENSG00000112282 E009 143.4534451 0.0018232076 1.651934e-02 8.370971e-02 6 131587709 131587842 134 - 2.041 2.134 0.312
ENSG00000112282 E010 65.2983150 0.0011594563 5.780646e-02 1.979047e-01 6 131587843 131587846 4 - 1.701 1.800 0.334
ENSG00000112282 E011 0.0000000       6 131589461 131589464 4 -      
ENSG00000112282 E012 139.2960471 0.0003135742 4.933484e-03 3.427644e-02 6 131589465 131589596 132 - 2.028 2.126 0.327
ENSG00000112282 E013 121.8442216 0.0004723600 4.341634e-02 1.636284e-01 6 131590322 131590409 88 - 1.977 2.052 0.253
ENSG00000112282 E014 78.9244523 0.0005403179 7.274731e-01 8.527439e-01 6 131590410 131590442 33 - 1.811 1.791 -0.068
ENSG00000112282 E015 179.9107278 0.0004690589 7.147636e-03 4.531257e-02 6 131591313 131591527 215 - 2.144 2.227 0.280
ENSG00000112282 E016 25.0484208 0.0463243674 5.899168e-01 7.636706e-01 6 131591528 131591984 457 - 1.313 1.355 0.147
ENSG00000112282 E017 97.7621370 0.0004370771 1.118919e-01 3.022521e-01 6 131592388 131592460 73 - 1.887 1.953 0.222
ENSG00000112282 E018 24.1158052 0.1437246417 7.944095e-01 8.929694e-01 6 131592461 131593005 545 - 1.317 1.260 -0.201
ENSG00000112282 E019 134.1591455 0.0004149923 1.108739e-01 3.004130e-01 6 131593006 131593171 166 - 2.025 2.081 0.189
ENSG00000112282 E020 154.3225591 0.0003028666 6.109679e-02 2.052306e-01 6 131594099 131594335 237 - 2.083 2.145 0.206
ENSG00000112282 E021 121.2812860 0.0003641010 1.876920e-01 4.140019e-01 6 131595947 131596163 217 - 1.983 2.031 0.164
ENSG00000112282 E022 1.1010935 0.0153787590 7.458837e-01   6 131596164 131596517 354 - 0.291 0.218 -0.546
ENSG00000112282 E023 110.1391337 0.0003871775 6.874174e-01 8.274394e-01 6 131596518 131596688 171 - 1.948 1.963 0.049
ENSG00000112282 E024 0.5008152 0.0417338386 6.728204e-01   6 131598251 131598286 36 - 0.170 0.000 -8.921
ENSG00000112282 E025 111.5724312 0.0004249009 9.683631e-01 9.860135e-01 6 131598287 131598467 181 - 1.954 1.950 -0.013
ENSG00000112282 E026 120.1823694 0.0003499061 8.453124e-01 9.222720e-01 6 131598556 131598761 206 - 1.985 1.990 0.017
ENSG00000112282 E027 92.4040511 0.0004390542 3.650742e-01 6.000178e-01 6 131600038 131600162 125 - 1.883 1.839 -0.149
ENSG00000112282 E028 87.1312991 0.0006442584 3.319716e-01 5.708100e-01 6 131602218 131602298 81 - 1.862 1.813 -0.166
ENSG00000112282 E029 89.5271657 0.0061464342 2.959159e-01 5.364078e-01 6 131602299 131602381 83 - 1.877 1.807 -0.239
ENSG00000112282 E030 119.6653663 0.0102663098 2.679560e-01 5.076257e-01 6 131603030 131603204 175 - 2.003 1.916 -0.292
ENSG00000112282 E031 115.7015955 0.0003498017 2.299890e-01 4.651451e-01 6 131604178 131604320 143 - 1.981 1.928 -0.178
ENSG00000112282 E032 135.1618136 0.0043495934 1.060124e-01 2.923714e-01 6 131605240 131605485 246 - 2.056 1.972 -0.281
ENSG00000112282 E033 102.7479661 0.0009390602 7.314317e-01 8.550674e-01 6 131606479 131606624 146 - 1.926 1.907 -0.064
ENSG00000112282 E034 91.2710721 0.0004575014 2.637431e-01 5.030192e-01 6 131607928 131608071 144 - 1.881 1.826 -0.185
ENSG00000112282 E035 47.8610995 0.0156256395 6.205218e-01 7.841610e-01 6 131610046 131610087 42 - 1.602 1.554 -0.162
ENSG00000112282 E036 80.4724009 0.0014142759 1.190489e-01 3.143131e-01 6 131610088 131610246 159 - 1.829 1.742 -0.292
ENSG00000112282 E037 3.5207975 0.0704566094 6.175966e-01 7.822118e-01 6 131615324 131615341 18 - 0.592 0.472 -0.567
ENSG00000112282 E038 80.4175356 0.0004744607 6.945418e-04 7.398179e-03 6 131615907 131616002 96 - 1.847 1.664 -0.620
ENSG00000112282 E039 94.4930644 0.0012479300 7.996389e-07 2.338909e-05 6 131618407 131618519 113 - 1.925 1.657 -0.906
ENSG00000112282 E040 72.0716759 0.0005056406 1.401416e-04 1.981457e-03 6 131619827 131619896 70 - 1.803 1.583 -0.749
ENSG00000112282 E041 79.9809132 0.0005233136 5.315543e-03 3.627930e-02 6 131620628 131620729 102 - 1.837 1.687 -0.506
ENSG00000112282 E042 70.5300757 0.0005526165 6.363732e-02 2.109110e-01 6 131621881 131621979 99 - 1.779 1.676 -0.350
ENSG00000112282 E043 93.5982260 0.0004698274 7.120298e-04 7.543767e-03 6 131623351 131623462 112 - 1.907 1.737 -0.572
ENSG00000112282 E044 83.6815339 0.0018395369 2.370539e-03 1.950635e-02 6 131624865 131624989 125 - 1.858 1.687 -0.578
ENSG00000112282 E045 0.6600180 0.0195110326 4.533159e-01   6 131626961 131627395 435 - 0.214 0.000 -9.334
ENSG00000112282 E046 70.9647467 0.0007619016 2.508302e-02 1.124785e-01 6 131627396 131627483 88 - 1.784 1.657 -0.429
ENSG00000112282 E047 52.8301551 0.0059940894 2.001601e-01 4.298949e-01 6 131627641 131627672 32 - 1.656 1.565 -0.312
ENSG00000112282 E048 75.8246295 0.0188270030 7.429005e-02 2.333387e-01 6 131628011 131628242 232 - 1.818 1.676 -0.482