ENSG00000112249

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369143 ENSG00000112249 HEK293_OSMI2_6hA HEK293_TMG_6hB ASCC3 protein_coding protein_coding 12.03094 3.172171 22.38639 0.7843414 0.7170084 2.815183 1.2152419 0.5613361 1.3128182 0.1178663 0.004721648 1.2112032 0.1273958 0.1876333 0.05876667 -0.1288667 0.0004436257 0.0004436257 FALSE FALSE
ENST00000369162 ENSG00000112249 HEK293_OSMI2_6hA HEK293_TMG_6hB ASCC3 protein_coding protein_coding 12.03094 3.172171 22.38639 0.7843414 0.7170084 2.815183 9.6983757 2.0522163 20.0759961 0.4121097 0.813417423 3.2839224 0.6885500 0.6711667 0.89636667 0.2252000 0.0006012916 0.0004436257 FALSE TRUE
ENST00000518006 ENSG00000112249 HEK293_OSMI2_6hA HEK293_TMG_6hB ASCC3 protein_coding retained_intron 12.03094 3.172171 22.38639 0.7843414 0.7170084 2.815183 0.9183366 0.5586190 0.6530617 0.2799273 0.239933098 0.2216807 0.1740917 0.1411667 0.02933333 -0.1118333 0.6334438398 0.0004436257   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000112249 E001 109.4606271 1.0626103629 2.262679e-01 4.609529e-01 6 100508194 100509217 1024 - 1.757 2.239 1.619
ENSG00000112249 E002 128.5946010 1.5226231515 3.764516e-01 6.094094e-01 6 100509218 100509533 316 - 1.855 2.223 1.235
ENSG00000112249 E003 107.6981891 0.0169327648 8.565520e-03 5.189369e-02 6 100509932 100510107 176 - 1.808 2.040 0.779
ENSG00000112249 E004 1.7739078 0.0109114627 3.823349e-02 1.501914e-01 6 100510108 100510308 201 - 0.254 0.669 2.207
ENSG00000112249 E005 141.3314443 0.0003108542 5.844956e-05 9.526903e-04 6 100512709 100512918 210 - 1.931 2.130 0.668
ENSG00000112249 E006 123.2611987 0.0003288919 8.782600e-06 1.875377e-04 6 100516180 100516327 148 - 1.866 2.093 0.760
ENSG00000112249 E007 115.4022368 0.0038651202 7.392587e-03 4.651124e-02 6 100517991 100518142 152 - 1.844 2.023 0.603
ENSG00000112249 E008 139.6193508 0.0020787150 5.962081e-03 3.954152e-02 6 100540163 100540387 225 - 1.929 2.093 0.549
ENSG00000112249 E009 100.2152793 0.0005470603 9.377360e-02 2.707674e-01 6 100589634 100589768 135 - 1.791 1.912 0.407
ENSG00000112249 E010 86.8159160 0.0005105026 9.369063e-03 5.540250e-02 6 100589948 100590059 112 - 1.724 1.897 0.583
ENSG00000112249 E011 74.6022822 0.0006476987 6.393179e-01 7.964414e-01 6 100601810 100601935 126 - 1.682 1.687 0.017
ENSG00000112249 E012 63.7516115 0.0006897273 7.096184e-01 8.415764e-01 6 100605568 100605700 133 - 1.617 1.626 0.031
ENSG00000112249 E013 74.2262559 0.0005301735 8.965875e-01 9.501359e-01 6 100606740 100606860 121 - 1.677 1.703 0.089
ENSG00000112249 E014 108.5014568 0.0005331023 3.329475e-01 5.715906e-01 6 100606951 100607088 138 - 1.834 1.917 0.278
ENSG00000112249 E015 113.8229071 0.0003884649 6.911202e-02 2.230061e-01 6 100625192 100625334 143 - 1.850 1.971 0.408
ENSG00000112249 E016 92.2368498 0.0004780140 1.193475e-01 3.147965e-01 6 100627590 100627710 121 - 1.759 1.876 0.396
ENSG00000112249 E017 106.7440731 0.0006189247 9.327735e-01 9.685126e-01 6 100627842 100627987 146 - 1.832 1.871 0.132
ENSG00000112249 E018 94.3588197 0.0006503777 1.967883e-01 4.255159e-01 6 100629015 100629181 167 - 1.788 1.748 -0.135
ENSG00000112249 E019 82.9747257 0.0031974267 2.493420e-03 2.029004e-02 6 100631128 100631213 86 - 1.746 1.564 -0.616
ENSG00000112249 E020 127.7468466 0.0004039888 3.757884e-04 4.495728e-03 6 100638601 100638821 221 - 1.928 1.776 -0.514
ENSG00000112249 E021 92.8920796 0.0008112674 3.481264e-01 5.855933e-01 6 100642581 100642749 169 - 1.780 1.762 -0.062
ENSG00000112249 E022 79.2716623 0.0024926437 4.763533e-01 6.844957e-01 6 100644031 100644129 99 - 1.711 1.702 -0.032
ENSG00000112249 E023 87.0821268 0.0032982551 1.358694e-01 3.411371e-01 6 100646615 100646769 155 - 1.756 1.694 -0.208
ENSG00000112249 E024 62.6109373 0.0033525844 1.657260e-01 3.847553e-01 6 100647226 100647287 62 - 1.613 1.543 -0.238
ENSG00000112249 E025 98.5735040 0.0013504247 3.116328e-01 5.519983e-01 6 100647288 100647451 164 - 1.805 1.782 -0.077
ENSG00000112249 E026 99.8114747 0.0005560112 3.054360e-01 5.460581e-01 6 100650538 100650714 177 - 1.810 1.789 -0.072
ENSG00000112249 E027 78.0656748 0.0026734439 4.189259e-02 1.596715e-01 6 100651560 100651646 87 - 1.712 1.606 -0.358
ENSG00000112249 E028 114.3996932 0.0090704749 1.995312e-02 9.572300e-02 6 100652725 100652889 165 - 1.878 1.752 -0.426
ENSG00000112249 E029 101.0965877 0.0045085732 9.496738e-03 5.594244e-02 6 100655699 100655818 120 - 1.825 1.687 -0.466
ENSG00000112249 E030 127.7584224 0.0004007917 6.062761e-06 1.360820e-04 6 100661806 100662030 225 - 1.932 1.719 -0.718
ENSG00000112249 E031 86.9375761 0.0027164240 9.784176e-03 5.719127e-02 6 100662345 100662536 192 - 1.759 1.617 -0.480
ENSG00000112249 E032 67.4345078 0.0008400348 2.919756e-03 2.291850e-02 6 100679618 100679752 135 - 1.655 1.469 -0.636
ENSG00000112249 E033 0.1614157 0.0333905075 7.426416e-01   6 100715130 100715461 332 - 0.047 0.001 -6.276
ENSG00000112249 E034 59.4039967 0.0008627090 2.146313e-02 1.008530e-01 6 100715462 100715533 72 - 1.598 1.455 -0.488
ENSG00000112249 E035 83.3585405 0.0023966352 1.413668e-03 1.299661e-02 6 100718075 100718251 177 - 1.746 1.555 -0.649
ENSG00000112249 E036 79.3285053 0.0009543273 7.967580e-03 4.916328e-02 6 100725539 100725703 165 - 1.721 1.576 -0.491
ENSG00000112249 E037 69.5124060 0.0032892901 2.533508e-02 1.132231e-01 6 100766565 100766705 141 - 1.665 1.531 -0.457
ENSG00000112249 E038 101.2907655 0.0003725675 2.536540e-06 6.422587e-05 6 100767145 100767345 201 - 1.837 1.576 -0.886
ENSG00000112249 E039 73.0565861 0.0005801490 9.615669e-09 4.541050e-07 6 100798713 100798838 126 - 1.705 1.265 -1.513
ENSG00000112249 E040 67.6825139 0.0006135593 1.662689e-05 3.263933e-04 6 100799431 100799572 142 - 1.668 1.362 -1.048
ENSG00000112249 E041 80.2894429 0.0005101307 8.531628e-05 1.310006e-03 6 100800300 100800504 205 - 1.735 1.495 -0.818
ENSG00000112249 E042 65.3353049 0.0005717799 2.816100e-03 2.229239e-02 6 100805760 100805880 121 - 1.644 1.455 -0.645
ENSG00000112249 E043 0.5233527 0.0214904684 2.906825e-01   6 100848004 100848147 144 - 0.089 0.283 2.016
ENSG00000112249 E044 89.1817881 0.0005464905 4.240241e-02 1.609824e-01 6 100848148 100848419 272 - 1.768 1.679 -0.300
ENSG00000112249 E045 89.2351811 0.0029582207 1.532123e-02 7.927537e-02 6 100848420 100848707 288 - 1.773 1.644 -0.437
ENSG00000112249 E046 70.8188592 0.0011824570 1.226055e-33 1.360865e-30 6 100856303 100859202 2900 - 1.531 2.155 2.106
ENSG00000112249 E047 76.3092504 0.0098616349 1.314271e-01 3.340370e-01 6 100864064 100864214 151 - 1.703 1.614 -0.303
ENSG00000112249 E048 59.7529090 0.0468848183 3.776859e-01 6.103300e-01 6 100867908 100868032 125 - 1.598 1.521 -0.263
ENSG00000112249 E049 23.7978598 0.0016737629 3.350470e-01 5.736044e-01 6 100868033 100868038 6 - 1.216 1.141 -0.266
ENSG00000112249 E050 59.3180710 0.0055724207 2.793973e-01 5.195008e-01 6 100881061 100881372 312 - 1.594 1.542 -0.180