ENSG00000112237

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000518714 ENSG00000112237 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNC protein_coding protein_coding 42.3063 6.642522 75.41882 0.7374179 3.656643 3.503142 3.576245 1.284281 6.604684 0.1470429 0.1155089 2.353522 0.1276583 0.1946667 0.08806667 -0.10660000 0.003014112 0.003014112 FALSE TRUE
ENST00000520429 ENSG00000112237 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNC protein_coding protein_coding 42.3063 6.642522 75.41882 0.7374179 3.656643 3.503142 28.350538 4.471668 49.702262 0.6958316 2.1439576 3.471494 0.6717167 0.6696667 0.65943333 -0.01023333 0.980612136 0.003014112 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000112237 E001 81.6893197 0.0213531915 0.2700505915 0.510046173 6 99542387 99542501 115 - 1.687 1.832 0.491
ENSG00000112237 E002 588.4751119 0.0327745503 0.8786216448 0.940587913 6 99542502 99543288 787 - 2.548 2.613 0.219
ENSG00000112237 E003 193.9297674 0.0348954561 0.8268248812 0.911932463 6 99543289 99543447 159 - 2.072 2.105 0.111
ENSG00000112237 E004 101.8368423 0.0359234565 0.4206868703 0.644187320 6 99543448 99543463 16 - 1.802 1.772 -0.103
ENSG00000112237 E005 89.3207905 0.0318126174 0.9970772978 1.000000000 6 99543464 99543474 11 - 1.737 1.788 0.172
ENSG00000112237 E006 256.6393106 0.0158365485 0.1638480143 0.382408110 6 99543475 99543609 135 - 2.201 2.152 -0.163
ENSG00000112237 E007 40.3861741 0.0577403496 0.0050573160 0.034933845 6 99543780 99544178 399 - 1.338 1.767 1.467
ENSG00000112237 E008 30.7700125 0.0092872992 0.1923054670 0.419827632 6 99544179 99544205 27 - 1.274 1.447 0.600
ENSG00000112237 E009 47.0324336 0.0026613147 0.0006853888 0.007316285 6 99544206 99544273 68 - 1.433 1.717 0.969
ENSG00000112237 E010 221.9055537 0.0110898463 0.2650662744 0.504392466 6 99545112 99545167 56 - 2.136 2.114 -0.073
ENSG00000112237 E011 189.8402974 0.0096005969 0.4748604379 0.683483978 6 99545168 99545204 37 - 2.066 2.070 0.013
ENSG00000112237 E012 189.2900936 0.0072675334 0.1612718130 0.378648736 6 99545205 99545230 26 - 2.069 2.031 -0.126
ENSG00000112237 E013 242.3123748 0.0002573534 0.0579386755 0.198158066 6 99546395 99546474 80 - 2.180 2.149 -0.106
ENSG00000112237 E014 3.0030542 0.2957115818 0.5316903918 0.723227463 6 99549312 99549388 77 - 0.463 0.289 -1.010
ENSG00000112237 E015 1.6476690 0.2047213900 0.9521163158 0.978008729 6 99549389 99549399 11 - 0.300 0.290 -0.063
ENSG00000112237 E016 186.1454086 0.0150129809 0.7314182291 0.855063387 6 99549508 99549572 65 - 2.055 2.099 0.147
ENSG00000112237 E017 84.4656695 0.3884972441 0.3490999435 0.586462427 6 99549573 99549575 3 - 1.700 1.859 0.539
ENSG00000112237 E018 4.9194786 0.0104763141 0.8183520176 0.907091180 6 99549576 99549647 72 - 0.605 0.590 -0.067
ENSG00000112237 E019 145.7857672 0.4727755623 0.3790969727 0.611482805 6 99550218 99550309 92 - 1.939 2.058 0.400
ENSG00000112237 E020 3.2410017 0.2390862575 0.1039491680 0.288758458 6 99550571 99550610 40 - 0.412 0.829 1.860
ENSG00000112237 E021 2.1205300 0.1369367911 0.7737401676 0.880959362 6 99550856 99550992 137 - 0.375 0.294 -0.505
ENSG00000112237 E022 70.1721955 0.9875122991 0.5328079732 0.724049744 6 99550993 99550993 1 - 1.631 1.710 0.266
ENSG00000112237 E023 84.1006540 1.3049815869 0.6021159424 0.771558732 6 99550994 99551028 35 - 1.711 1.766 0.187
ENSG00000112237 E024 88.9082057 1.3271381120 0.5800259121 0.757175673 6 99551840 99551895 56 - 1.731 1.817 0.292
ENSG00000112237 E025 4.3194385 0.0100490907 0.0965383290 0.275712701 6 99557240 99558413 1174 - 0.514 0.832 1.356
ENSG00000112237 E026 0.8086220 0.0894409956 0.5246586839   6 99558414 99558496 83 - 0.155 0.295 1.176
ENSG00000112237 E027 54.3387722 0.5344238769 0.4150716227 0.639852476 6 99558497 99558500 4 - 1.520 1.629 0.375
ENSG00000112237 E028 91.1201007 0.0717033255 0.7883003708 0.889529584 6 99558501 99558548 48 - 1.751 1.769 0.062
ENSG00000112237 E029 166.3558787 0.0003155122 0.0121897573 0.067221989 6 99561367 99561436 70 - 2.024 1.948 -0.255
ENSG00000112237 E030 213.4322465 0.0002534555 0.0019253629 0.016571431 6 99561597 99561681 85 - 2.132 2.045 -0.291
ENSG00000112237 E031 0.3228314 0.3014251997 1.0000000000   6 99561682 99561872 191 - 0.085 0.000 -8.198
ENSG00000112237 E032 1.9618702 0.2080955357 0.1124041061 0.303146032 6 99562020 99562841 822 - 0.275 0.681 2.106
ENSG00000112237 E033 167.9826345 0.0045313129 0.0864120458 0.257247295 6 99562842 99562948 107 - 2.023 1.961 -0.209
ENSG00000112237 E034 1.6328322 0.4392518266 1.0000000000 1.000000000 6 99566898 99567038 141 - 0.297 0.295 -0.010
ENSG00000112237 E035 0.1723744 0.0359429236 0.0384550659   6 99568178 99568495 318 - 0.000 0.293 13.475
ENSG00000112237 E036 119.2620803 1.4139162668 0.5006911918 0.701245982 6 99568496 99568717 222 - 1.846 2.011 0.555
ENSG00000112237 E037 8.2701714 0.4107636983 0.3371306811 0.575535487 6 99568718 99568825 108 - 0.752 0.985 0.897