ENSG00000112078

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373731 ENSG00000112078 HEK293_OSMI2_6hA HEK293_TMG_6hB KCTD20 protein_coding protein_coding 23.4136 11.85523 33.29398 3.167341 1.93937 1.488955 18.2674413 8.1454800 29.6882915 1.9653241 1.94521728 1.864538 0.73668750 0.69856667 0.891333333 0.1927667 4.523179e-03 5.631214e-08 FALSE TRUE
ENST00000443316 ENSG00000112078 HEK293_OSMI2_6hA HEK293_TMG_6hB KCTD20 protein_coding processed_transcript 23.4136 11.85523 33.29398 3.167341 1.93937 1.488955 0.7296243 0.7333236 0.2375638 0.2818555 0.05087196 -1.586190 0.04332083 0.05803333 0.007133333 -0.0509000 2.952061e-06 5.631214e-08   FALSE
ENST00000474988 ENSG00000112078 HEK293_OSMI2_6hA HEK293_TMG_6hB KCTD20 protein_coding processed_transcript 23.4136 11.85523 33.29398 3.167341 1.93937 1.488955 1.5021070 1.4221726 0.0516633 0.4341892 0.05166330 -4.537649 0.10060000 0.11586667 0.001533333 -0.1143333 5.631214e-08 5.631214e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000112078 E001 0.3453689 0.0267299764 4.815850e-01   6 36442767 36442924 158 + 0.077 0.187 1.480
ENSG00000112078 E002 1.3519732 0.0138293047 4.560932e-02   6 36442925 36442986 62 + 0.199 0.567 2.214
ENSG00000112078 E003 2.2623209 0.0093317465 9.408737e-04 0.0094288918 6 36442987 36442999 13 + 0.249 0.805 2.797
ENSG00000112078 E004 3.5883263 0.0073694049 3.275414e-02 0.1353671971 6 36443000 36443006 7 + 0.495 0.840 1.476
ENSG00000112078 E005 4.7900301 0.0058942116 2.633885e-03 0.0211736943 6 36443007 36443011 5 + 0.546 0.983 1.777
ENSG00000112078 E006 6.9780501 0.0225059054 2.118855e-02 0.0999611347 6 36443012 36443016 5 + 0.736 1.072 1.281
ENSG00000112078 E007 7.4239273 0.0291909317 1.381285e-02 0.0735918580 6 36443017 36443020 4 + 0.750 1.110 1.359
ENSG00000112078 E008 13.3077621 0.0242744647 7.681527e-02 0.2384172385 6 36443021 36443027 7 + 1.035 1.261 0.811
ENSG00000112078 E009 17.4193595 0.0444762880 2.259936e-01 0.4605660702 6 36443028 36443035 8 + 1.168 1.332 0.577
ENSG00000112078 E010 17.2884914 0.0454483161 2.590329e-01 0.4979087729 6 36443036 36443037 2 + 1.168 1.322 0.542
ENSG00000112078 E011 40.4387477 0.0036596352 1.274330e-01 0.3277754483 6 36443038 36443111 74 + 1.532 1.659 0.434
ENSG00000112078 E012 2.6374295 0.0082869677 1.268805e-04 0.0018221761 6 36443418 36443530 113 + 0.249 0.873 3.062
ENSG00000112078 E013 1.9415825 0.0547579984 2.462483e-02 0.1110602606 6 36443531 36443723 193 + 0.249 0.684 2.309
ENSG00000112078 E014 0.8156366 0.0165446909 5.640970e-01   6 36451534 36451632 99 + 0.199 0.317 0.890
ENSG00000112078 E015 0.0000000       6 36452564 36452680 117 +      
ENSG00000112078 E016 1.6764338 0.0769058800 5.363257e-01 0.7265278691 6 36465601 36465698 98 + 0.436 0.317 -0.687
ENSG00000112078 E017 137.1429523 0.0019807785 4.303243e-02 0.1626476644 6 36470052 36470257 206 + 2.103 2.054 -0.164
ENSG00000112078 E018 210.7064970 0.0003600786 2.127072e-06 0.0000550985 6 36474789 36475062 274 + 2.301 2.196 -0.353
ENSG00000112078 E019 138.4608133 0.0003121028 7.557270e-05 0.0011830736 6 36479121 36479223 103 + 2.118 2.009 -0.364
ENSG00000112078 E020 151.6519633 0.0019178775 4.423407e-02 0.1656987049 6 36479591 36479711 121 + 2.144 2.095 -0.164
ENSG00000112078 E021 210.2954366 0.0002574618 1.222728e-03 0.0116010604 6 36481562 36481759 198 + 2.288 2.228 -0.201
ENSG00000112078 E022 130.9628337 0.0009943338 6.425119e-02 0.2122496339 6 36484714 36484824 111 + 2.078 2.038 -0.135
ENSG00000112078 E023 2279.9183767 0.0015750782 8.683881e-04 0.0088359661 6 36486883 36491143 4261 + 3.288 3.349 0.203