ENSG00000111912

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368357 ENSG00000111912 HEK293_OSMI2_6hA HEK293_TMG_6hB NCOA7 protein_coding protein_coding 5.496872 2.738734 8.643934 0.7041999 0.5396052 1.654589 0.5338908 0.07588998 1.3942684 0.04577171 0.5265277 4.0311851 0.08535833 0.03276667 0.16516667 0.13240000 3.929804e-01 6.561395e-06 FALSE TRUE
ENST00000392477 ENSG00000111912 HEK293_OSMI2_6hA HEK293_TMG_6hB NCOA7 protein_coding protein_coding 5.496872 2.738734 8.643934 0.7041999 0.5396052 1.654589 1.1380247 0.66039043 1.8139853 0.33385869 0.7285557 1.4440207 0.18298750 0.19176667 0.20496667 0.01320000 9.676068e-01 6.561395e-06 FALSE TRUE
ENST00000417494 ENSG00000111912 HEK293_OSMI2_6hA HEK293_TMG_6hB NCOA7 protein_coding protein_coding 5.496872 2.738734 8.643934 0.7041999 0.5396052 1.654589 0.4682390 0.00000000 0.7147281 0.00000000 0.3790505 6.1793679 0.06175417 0.00000000 0.08823333 0.08823333 5.227329e-01 6.561395e-06 FALSE FALSE
ENST00000433571 ENSG00000111912 HEK293_OSMI2_6hA HEK293_TMG_6hB NCOA7 protein_coding processed_transcript 5.496872 2.738734 8.643934 0.7041999 0.5396052 1.654589 0.5877963 0.00000000 1.6283324 0.00000000 0.4497030 7.3560843 0.08467917 0.00000000 0.18316667 0.18316667 1.685693e-05 6.561395e-06 FALSE FALSE
MSTRG.28918.1 ENSG00000111912 HEK293_OSMI2_6hA HEK293_TMG_6hB NCOA7 protein_coding   5.496872 2.738734 8.643934 0.7041999 0.5396052 1.654589 1.9812205 1.66465185 1.2215258 0.51367921 0.3015537 -0.4434144 0.44087917 0.58346667 0.13963333 -0.44383333 6.561395e-06 6.561395e-06   FALSE
MSTRG.28918.3 ENSG00000111912 HEK293_OSMI2_6hA HEK293_TMG_6hB NCOA7 protein_coding   5.496872 2.738734 8.643934 0.7041999 0.5396052 1.654589 0.4095487 0.17855591 1.3012819 0.12921385 0.2071394 2.7979137 0.07333333 0.11793333 0.15096667 0.03303333 7.227695e-01 6.561395e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111912 E001 4.0361266 0.0067454768 7.797534e-03 4.837086e-02 6 125781130 125781160 31 + 0.522 0.922 1.662
ENSG00000111912 E002 13.4679329 0.0035264378 1.575549e-05 3.112661e-04 6 125781161 125781371 211 + 0.950 1.376 1.523
ENSG00000111912 E003 9.7297290 0.0037992410 2.131220e-06 5.518780e-05 6 125786137 125786213 77 + 0.776 1.296 1.916
ENSG00000111912 E004 5.8990275 0.0046343349 2.495640e-13 2.885072e-11 6 125788726 125788924 199 + 0.380 1.296 3.747
ENSG00000111912 E005 1.4792388 0.0763320352 1.279748e-01 3.286067e-01 6 125790925 125790939 15 + 0.381 0.000 -11.045
ENSG00000111912 E006 2.9444823 0.0084277752 3.710963e-01 6.047910e-01 6 125790940 125790959 20 + 0.542 0.370 -0.888
ENSG00000111912 E007 3.4265164 0.0074968583 2.370918e-01 4.731966e-01 6 125790960 125790964 5 + 0.597 0.370 -1.137
ENSG00000111912 E008 7.6041777 0.0041127774 9.753495e-01 9.895025e-01 6 125790965 125791067 103 + 0.839 0.847 0.033
ENSG00000111912 E009 1.2920612 0.0130682457 2.269723e-01   6 125796680 125796797 118 + 0.249 0.479 1.375
ENSG00000111912 E010 0.0000000       6 125810135 125810347 213 +      
ENSG00000111912 E011 0.0000000       6 125815218 125815290 73 +      
ENSG00000111912 E012 19.0151145 0.0022115049 7.761017e-02 2.400377e-01 6 125815291 125815404 114 + 1.226 1.044 -0.655
ENSG00000111912 E013 29.3857973 0.0012527730 2.463027e-01 4.839060e-01 6 125855020 125855240 221 + 1.399 1.310 -0.309
ENSG00000111912 E014 0.0000000       6 125855241 125855590 350 +      
ENSG00000111912 E015 20.3653176 0.0023252168 4.705421e-01 6.804520e-01 6 125874889 125874968 80 + 1.242 1.178 -0.228
ENSG00000111912 E016 24.6698350 0.0027857540 1.617268e-02 8.241786e-02 6 125878263 125878370 108 + 1.345 1.116 -0.810
ENSG00000111912 E017 25.6683136 0.0018334227 2.791211e-02 1.210233e-01 6 125881090 125881203 114 + 1.357 1.158 -0.699
ENSG00000111912 E018 28.4563080 0.0015934305 2.526775e-03 2.050875e-02 6 125882426 125882551 126 + 1.410 1.138 -0.956
ENSG00000111912 E019 33.1941899 0.0012891296 3.794631e-04 4.533988e-03 6 125885159 125885343 185 + 1.480 1.178 -1.052
ENSG00000111912 E020 12.3834297 0.0029152531 1.638720e-01 3.824431e-01 6 125888939 125888971 33 + 1.057 0.887 -0.632
ENSG00000111912 E021 111.8427552 0.0004076277 1.047083e-02 6.014909e-02 6 125888972 125889981 1010 + 1.969 1.869 -0.334
ENSG00000111912 E022 34.8863911 0.0011858529 5.313758e-01 7.229901e-01 6 125890642 125890810 169 + 1.464 1.423 -0.141
ENSG00000111912 E023 0.0000000       6 125899909 125900021 113 +      
ENSG00000111912 E024 42.9760558 0.0010128254 3.858024e-01 6.171232e-01 6 125915333 125915480 148 + 1.532 1.593 0.208
ENSG00000111912 E025 0.3040503 0.0274424043 1.000000e+00   6 125919224 125919304 81 + 0.117 0.000 -9.273
ENSG00000111912 E026 0.3453689 0.0290890969 2.851495e-01   6 125919305 125919431 127 + 0.063 0.223 2.115
ENSG00000111912 E027 36.0469032 0.0013236225 7.201629e-01 8.483019e-01 6 125920943 125921068 126 + 1.475 1.455 -0.071
ENSG00000111912 E028 33.5840199 0.0019817072 8.021107e-01 8.975531e-01 6 125922682 125922834 153 + 1.440 1.464 0.083
ENSG00000111912 E029 26.7477910 0.0015004787 9.191329e-01 9.617896e-01 6 125927663 125927758 96 + 1.339 1.351 0.045
ENSG00000111912 E030 22.7376843 0.0016137875 2.989011e-01 5.393720e-01 6 125928174 125928247 74 + 1.257 1.351 0.328
ENSG00000111912 E031 169.7053769 0.0011699089 3.518676e-03 2.645558e-02 6 125928636 125932034 3399 + 2.108 2.204 0.320