ENSG00000111880

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369475 ENSG00000111880 HEK293_OSMI2_6hA HEK293_TMG_6hB RNGTT protein_coding protein_coding 9.427756 2.052195 18.33015 0.4810729 1.338745 3.152753 1.859875 0.07733763 4.848653 0.07733763 0.9795815 5.797809 0.1189750 0.0296 0.2593333 0.2297333 0.06356612 0.03110491 FALSE TRUE
ENST00000369485 ENSG00000111880 HEK293_OSMI2_6hA HEK293_TMG_6hB RNGTT protein_coding protein_coding 9.427756 2.052195 18.33015 0.4810729 1.338745 3.152753 7.106590 1.91309435 13.481496 0.41059495 0.4680518 2.810549 0.8484958 0.9452 0.7406667 -0.2045333 0.03110491 0.03110491 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111880 E001 355.5115468 1.7872857829 0.409384951 0.63558057 6 88609897 88612718 2822 - 2.304 2.643 1.130
ENSG00000111880 E002 67.3276107 0.9220694833 0.384185552 0.61574766 6 88612719 88612882 164 - 1.609 1.851 0.822
ENSG00000111880 E003 80.4782290 0.0004769977 0.756388183 0.87046232 6 88614272 88614395 124 - 1.716 1.806 0.305
ENSG00000111880 E004 0.5067846 0.0217681645 0.364352182   6 88677994 88678352 359 - 0.090 0.279 1.965
ENSG00000111880 E005 62.0745870 0.0270782916 0.206279533 0.43733002 6 88678353 88678419 67 - 1.613 1.611 -0.004
ENSG00000111880 E006 0.1426347 0.0318632368 0.937293051   6 88769770 88769773 4 - 0.047 0.001 -5.218
ENSG00000111880 E007 77.3336273 0.0335489799 0.181391887 0.40583519 6 88769774 88769874 101 - 1.707 1.689 -0.060
ENSG00000111880 E008 57.2829826 0.0411469111 0.588284677 0.76253886 6 88801564 88801632 69 - 1.570 1.630 0.207
ENSG00000111880 E009 104.4074947 0.0213811250 0.271501745 0.51137716 6 88844357 88844521 165 - 1.829 1.864 0.118
ENSG00000111880 E010 66.6104538 0.0115714808 0.118429416 0.31327456 6 88849755 88849826 72 - 1.644 1.634 -0.032
ENSG00000111880 E011 76.3832454 0.0182154602 0.434671721 0.65474971 6 88853629 88853764 136 - 1.695 1.749 0.185
ENSG00000111880 E012 65.7780200 0.0371651325 0.588626996 0.76277482 6 88890495 88890596 102 - 1.630 1.683 0.179
ENSG00000111880 E013 74.8593383 0.0260991479 0.056237497 0.19418546 6 88891806 88891915 110 - 1.699 1.631 -0.231
ENSG00000111880 E014 109.0378339 0.0149136107 0.044012034 0.16512218 6 88904715 88904955 241 - 1.855 1.823 -0.108
ENSG00000111880 E015 50.9716746 0.0109886068 0.017170894 0.08607139 6 88906365 88906440 76 - 1.541 1.445 -0.327
ENSG00000111880 E016 44.6285262 0.0190557253 0.056365837 0.19449002 6 88928985 88929073 89 - 1.480 1.404 -0.261
ENSG00000111880 E017 45.5499850 0.0187999758 0.008343859 0.05090273 6 88929164 88929267 104 - 1.497 1.334 -0.562
ENSG00000111880 E018 47.5269258 0.0346004150 0.224536037 0.45885037 6 88941071 88941180 110 - 1.501 1.483 -0.061
ENSG00000111880 E019 55.6911029 0.0240501038 0.182496961 0.40723994 6 88963346 88963618 273 - 1.568 1.562 -0.020