ENSG00000111802

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378198 ENSG00000111802 HEK293_OSMI2_6hA HEK293_TMG_6hB TDP2 protein_coding protein_coding 28.68162 10.78561 46.24651 1.72298 2.091317 2.099211 26.7560853 9.335989 43.5543206 1.71788979 1.9020849 2.2207277 0.9133375 0.8571333 0.9419333 0.0848 3.221571e-02 6.334926e-06 FALSE  
ENST00000480495 ENSG00000111802 HEK293_OSMI2_6hA HEK293_TMG_6hB TDP2 protein_coding processed_transcript 28.68162 10.78561 46.24651 1.72298 2.091317 2.099211 0.8071007 1.037617 0.7594988 0.09765495 0.1674768 -0.4451209 0.0470125 0.1003000 0.0162000 -0.0841 6.334926e-06 6.334926e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111802 E001 362.0446314 0.0002094095 8.476494e-03 5.150834e-02 6 24649979 24650544 566 - 2.458 2.516 0.194
ENSG00000111802 E002 339.4421554 0.0002704948 6.699656e-01 8.162651e-01 6 24650545 24650914 370 - 2.440 2.452 0.042
ENSG00000111802 E003 171.2992148 0.0003002947 5.243953e-01 7.180763e-01 6 24650915 24650986 72 - 2.152 2.134 -0.060
ENSG00000111802 E004 175.6112130 0.0002457411 8.394238e-01 9.190593e-01 6 24650987 24651069 83 - 2.157 2.167 0.032
ENSG00000111802 E005 259.2010082 0.0002902295 7.680113e-02 2.383864e-01 6 24652983 24653153 171 - 2.337 2.294 -0.146
ENSG00000111802 E006 0.8843097 0.8708616875 7.626922e-01   6 24654378 24654411 34 - 0.231 0.216 -0.124
ENSG00000111802 E007 187.1302665 0.0003148819 3.603871e-02 1.443478e-01 6 24654412 24654530 119 - 2.199 2.136 -0.212
ENSG00000111802 E008 160.6995742 0.0004377093 3.547089e-04 4.284029e-03 6 24657812 24657903 92 - 2.144 2.019 -0.419
ENSG00000111802 E009 237.4104931 0.0003686568 1.014891e-03 1.002220e-02 6 24658561 24658734 174 - 2.307 2.215 -0.307
ENSG00000111802 E010 7.0456545 0.0653069587 2.049376e-03 1.739373e-02 6 24658735 24659172 438 - 0.664 1.160 1.895
ENSG00000111802 E011 6.2389899 0.0077415531 2.008882e-08 8.806255e-07 6 24665987 24666118 132 - 0.519 1.225 2.773
ENSG00000111802 E012 11.6871327 0.0029060747 5.472544e-12 4.943424e-10 6 24666119 24666525 407 - 0.774 1.449 2.456
ENSG00000111802 E013 188.3063559 0.0006784255 1.490029e-01 3.608408e-01 6 24666526 24666611 86 - 2.181 2.229 0.161
ENSG00000111802 E014 141.0685364 0.0032385345 1.384465e-01 3.451821e-01 6 24666698 24666930 233 - 2.053 2.120 0.222